PMID- 33292424
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201212
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 12
IP  - 1
DP  - 2020 Nov 4
TI  - Glucose metabolism-related gene polymorphisms as the risk predictors of type 2 
      diabetes.
PG  - 97
LID - 10.1186/s13098-020-00604-5 [doi]
LID - 97
AB  - Type 2 diabetes mellitus (T2DM) is a complex polygenic metabolic disease 
      characterized by elevated blood glucose. Multiple environmental and genetic 
      factors can increase the risk of T2DM and its complications, and genetic 
      polymorphisms are no exception. This review is mainly focused on the related 
      genes involved in glucose metabolic, including G6PC2, GCK, GCKR and OCT3. In this 
      review, we have summarized the results reported globally and found that the 
      genetic variants of GCK and OCT3 genes is a risk factor for T2DM while G6PC2 and 
      GCKR genes are controversial in different ethnic groups. Hopefully, this summary 
      could possibly help researchers and physicians understand the mechanism of T2DM 
      so as to diagnose and even prevent T2DM at early time.
FAU - Li, Cuilin
AU  - Li C
AUID- ORCID: 0000-0002-9480-1532
AD  - Department of Pharmacy, The Affiliated Zhuzhou Hospital Xiangya Medical College 
      CSU, Zhuzhou, 412007, Hunan, China. licuilincindy@163.com.
FAU - Yang, Yuping
AU  - Yang Y
AD  - Department of Pharmacy, The Affiliated Zhuzhou Hospital Xiangya Medical College 
      CSU, Zhuzhou, 412007, Hunan, China.
FAU - Liu, Xin
AU  - Liu X
AD  - Department of Pharmacy, The Affiliated Zhuzhou Hospital Xiangya Medical College 
      CSU, Zhuzhou, 412007, Hunan, China.
FAU - Li, Zhongyu
AU  - Li Z
AD  - Laboratory Medical Center, The Affiliated Zhuzhou Hospital Xiangya Medical 
      College CSU, Zhuzhou, 412007, China.
FAU - Liu, Hong
AU  - Liu H
AD  - Department of Metabolism and Endocrinology, The Affiliated Zhuzhou Hospital 
      Xiangya Medical College CSU, Zhuzhou, 412007, China.
FAU - Tan, Qiuhong
AU  - Tan Q
AD  - Department of Pharmacy, The Affiliated Zhuzhou Hospital Xiangya Medical College 
      CSU, Zhuzhou, 412007, Hunan, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201104
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC7643457
OTO - NOTNLM
OT  - G6PC2
OT  - GCK
OT  - GCKR
OT  - Genetic polymorphism
OT  - OCT3
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests.
EDAT- 2020/12/10 06:00
MHDA- 2020/12/10 06:01
PMCR- 2020/11/04
CRDT- 2020/12/09 05:44
PHST- 2020/06/29 00:00 [received]
PHST- 2020/10/26 00:00 [accepted]
PHST- 2020/10/22 00:00 [revised]
PHST- 2020/12/09 05:44 [entrez]
PHST- 2020/12/10 06:00 [pubmed]
PHST- 2020/12/10 06:01 [medline]
PHST- 2020/11/04 00:00 [pmc-release]
AID - 10.1186/s13098-020-00604-5 [pii]
AID - 604 [pii]
AID - 10.1186/s13098-020-00604-5 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2020 Nov 4;12(1):97. doi: 10.1186/s13098-020-00604-5.