PMID- 33293219
OWN - NLM
STAT- MEDLINE
DCOM- 20210317
LR  - 20210317
IS  - 1471-4981 (Electronic)
IS  - 1471-4906 (Linking)
VI  - 42
IP  - 1
DP  - 2021 Jan
TI  - Tolerogenic Dendritic Cells in Autoimmunity and Inflammatory Diseases.
PG  - 59-75
LID - S1471-4906(20)30259-3 [pii]
LID - 10.1016/j.it.2020.11.001 [doi]
AB  - Dendritic cells (DCs), the most efficient antigen-presenting cells, are necessary 
      for the effective activation of naive T cells. DCs can also acquire tolerogenic 
      functions in vivo and in vitro in response to various stimuli, including 
      interleukin (IL)-10, transforming growth factor (TGF)-beta, vitamin D3, 
      corticosteroids, and rapamycin. In this review, we provide a wide perspective on 
      the regulatory mechanisms, including crosstalk with other cell types, downstream 
      signaling pathways, transcription factors, and epigenetics, underlying the 
      acquisition of tolerogenesis by DCs, with a special focus on human studies. 
      Finally, we present clinical assays targeting, or based on, tolerogenic DCs in 
      inflammatory diseases. Our discussion provides a useful resource for better 
      understanding the biology of tolerogenic DCs and their manipulation to improve 
      the immunological fitness of patients with certain inflammatory conditions.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Morante-Palacios, Octavio
AU  - Morante-Palacios O
AD  - Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), 
      08916 Badalona, Barcelona, Spain; Germans Trias i Pujol Research Institute 
      (IGTP), 08916 Badalona, Barcelona, Spain.
FAU - Fondelli, Federico
AU  - Fondelli F
AD  - Division of Immunology, Germans Trias i Pujol Hospital, LCMN, Germans Trias i 
      Pujol Research Institute (IGTP), 08916 Badalona, Barcelona, Spain; Department of 
      Cell Biology, Physiology, Immunology, Autonomous University of Barcelona, 08193 
      Bellaterra, Barcelona, Spain.
FAU - Ballestar, Esteban
AU  - Ballestar E
AD  - Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), 
      08916 Badalona, Barcelona, Spain; Germans Trias i Pujol Research Institute 
      (IGTP), 08916 Badalona, Barcelona, Spain. Electronic address: 
      eballestar@carrerasresearch.org.
FAU - Martinez-Caceres, Eva M
AU  - Martinez-Caceres EM
AD  - Division of Immunology, Germans Trias i Pujol Hospital, LCMN, Germans Trias i 
      Pujol Research Institute (IGTP), 08916 Badalona, Barcelona, Spain; Department of 
      Cell Biology, Physiology, Immunology, Autonomous University of Barcelona, 08193 
      Bellaterra, Barcelona, Spain. Electronic address: 
      emmartinez.germanstrias@gencat.cat.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201205
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
SB  - IM
MH  - Autoimmunity
MH  - *Dendritic Cells/immunology/pathology
MH  - Humans
MH  - Immune Tolerance
MH  - *Inflammation/immunology/pathology
MH  - Signal Transduction
MH  - T-Lymphocytes/immunology/pathology
OTO - NOTNLM
OT  - autoimmune disease
OT  - dendritic cells
OT  - epigenetics
OT  - inflammatory disease
OT  - tolerogenic dendritic cells
EDAT- 2020/12/10 06:00
MHDA- 2021/03/18 06:00
CRDT- 2020/12/09 05:51
PHST- 2020/07/29 00:00 [received]
PHST- 2020/11/06 00:00 [revised]
PHST- 2020/11/08 00:00 [accepted]
PHST- 2020/12/10 06:00 [pubmed]
PHST- 2021/03/18 06:00 [medline]
PHST- 2020/12/09 05:51 [entrez]
AID - S1471-4906(20)30259-3 [pii]
AID - 10.1016/j.it.2020.11.001 [doi]
PST - ppublish
SO  - Trends Immunol. 2021 Jan;42(1):59-75. doi: 10.1016/j.it.2020.11.001. Epub 2020 
      Dec 5.