PMID- 33294246
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201210
IS  - 2090-6803 (Print)
IS  - 2090-6811 (Electronic)
VI  - 2020
DP  - 2020
TI  - Use of Extracorporeal Membrane Oxygenation in Pneumocystis Pneumonia of an Infant 
      with AIDS.
PG  - 8840131
LID - 10.1155/2020/8840131 [doi]
LID - 8840131
AB  - Pneumocystis pneumonia is a common complication of cellular immunosuppression and 
      may trigger severe pulmonary complications. Rapid onset of acquired 
      immunodeficiency syndrome is possible in infants infected with human 
      immunodeficiency virus (HIV). We report here the case of a 13-week-old girl who 
      was previously healthy presenting with altered immunity and refractory acute 
      respiratory distress syndrome (ARDS) initially attributed to bacterial pneumonia. 
      Venovenous extracorporeal membrane oxygenation (VV-ECMO) was initiated because 
      her condition was poor. An HIV infection was later fortuitously diagnosed after 
      accidental exposure of a nurse to the child's urine. The mother had congenitally 
      transmitted HIV to the child after late (undetected) infection during pregnancy. 
      The lung lesions were finally attributed to Pneumocystis pneumonia. We prescribed 
      combined antiretroviral, antibiotic, and steroid therapy aimed at preventing 
      immune reconstitution inflammatory syndrome. VV-ECMO weaning progressed over 30 
      days to the time of decannulation, rapidly followed by extubation and hospital 
      discharge. The case highlights the fact that rare curable causes of refractory 
      pediatric ARDS should always be investigated early. VV-ECMO should not be 
      excluded as an ARDS treatment for immunocompromised children.
CI  - Copyright (c) 2020 Gregoire Cane et al.
FAU - Cane, Gregoire
AU  - Cane G
AUID- ORCID: 0000-0002-4275-4383
AD  - CHU Bordeaux, Department of Anaesthesia and Critical Care, Magellan 
      Medico-Surgical Centre, F-33000 Bordeaux, France.
AD  - Univ. Bordeaux, INSERM, UMR 1034, Biology of Cardiovascular Diseases, F-33600 
      Pessac, France.
FAU - De Boislambert, Arnaud
AU  - De Boislambert A
AD  - CHU Bordeaux, Department of Anaesthesia and Critical Care, Magellan 
      Medico-Surgical Centre, F-33000 Bordeaux, France.
FAU - Sgro, Charlotte
AU  - Sgro C
AD  - CHU Bordeaux, Department of Anaesthesia and Critical Care, Magellan 
      Medico-Surgical Centre, F-33000 Bordeaux, France.
FAU - Lavedan, Pierre
AU  - Lavedan P
AD  - CHU Bordeaux, Department of Anaesthesia and Critical Care, Magellan 
      Medico-Surgical Centre, F-33000 Bordeaux, France.
FAU - Foulgoc, Helene
AU  - Foulgoc H
AD  - CHU Bordeaux, Department of Anaesthesia and Critical Care, Magellan 
      Medico-Surgical Centre, F-33000 Bordeaux, France.
FAU - Tafer, Nadir
AU  - Tafer N
AD  - CHU Bordeaux, Department of Anaesthesia and Critical Care, Magellan 
      Medico-Surgical Centre, F-33000 Bordeaux, France.
FAU - Ouattara, Alexandre
AU  - Ouattara A
AUID- ORCID: 0000-0002-7346-7539
AD  - CHU Bordeaux, Department of Anaesthesia and Critical Care, Magellan 
      Medico-Surgical Centre, F-33000 Bordeaux, France.
AD  - Univ. Bordeaux, INSERM, UMR 1034, Biology of Cardiovascular Diseases, F-33600 
      Pessac, France.
LA  - eng
PT  - Case Reports
DEP - 20201118
PL  - United States
TA  - Case Rep Pediatr
JT  - Case reports in pediatrics
JID - 101581030
PMC - PMC7688365
COIS- The authors declare no conflicts of interest.
EDAT- 2020/12/10 06:00
MHDA- 2020/12/10 06:01
PMCR- 2020/11/18
CRDT- 2020/12/09 06:14
PHST- 2020/08/26 00:00 [received]
PHST- 2020/11/09 00:00 [accepted]
PHST- 2020/12/09 06:14 [entrez]
PHST- 2020/12/10 06:00 [pubmed]
PHST- 2020/12/10 06:01 [medline]
PHST- 2020/11/18 00:00 [pmc-release]
AID - 10.1155/2020/8840131 [doi]
PST - epublish
SO  - Case Rep Pediatr. 2020 Nov 18;2020:8840131. doi: 10.1155/2020/8840131. 
      eCollection 2020.