PMID- 33294897
OWN - NLM
STAT- MEDLINE
DCOM- 20210422
LR  - 20210422
IS  - 1658-3175 (Electronic)
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 41
IP  - 12
DP  - 2020 Dec
TI  - Evaluation of irisin, retinol-binding protein 4, and leptin serum levels as 
      biomarkers of macrovascular complications involvement in Saudi type 2 diabetes 
      mellitus. A case-control study.
PG  - 1369-1374
LID - 10.15537/smj.2020.12.25461 [doi]
AB  - To evaluate adipokine serum values of irisin, retinol-binding protein 4, and 
      leptin in Saudi cases with type 2 diabetes mellitus (T2DM) for providing markers 
      of T2DM macrovascular complications. Methods: This case-control research was 
      carried out at Erfan Hospital, Jeddah, Saudi Arabia. The study included 138 
      subjects, classified into 3 groups: 46 T2DM patients with macrovascular 
      complications, 46 T2DM without macrovascular complications, and 46 controls. 
      Participants evaluated clinically and some biochemical parameters were 
      measured. Results: Diabetic with and without macrovascular complications showed 
      elevation of retinol-binding protein 4 (RBP4) and leptin; decreased irisin serum 
      levels versus controls. Serum irisin was lower (p=0.007), while RBP4 was higher 
      (p less than 0.0001) in T2DM patients with macrovascular complications versus 
      without. Irisin showed negative correlations with fasting blood glucose (FBG), 
      insulin, homeostatic model assessment of insulin resistance (HOMA-IR), RBP4, 
      hemoglobin A1C (HbA1C), triglyceride, cholesterol, and low-density lipoprotein 
      cholesterol. While RBP4 showed positive correlations with fasting blood glucose, 
      insulin, HOMA-IR, leptin, and HbA1c; but a negative association with high-density 
      lipoprotein cholesterol. Conclusion: Type 2 DM patients had raised RBP4 and 
      leptin, but lower irisin levels versus controls. Irisin was lower, but RBP4 was 
      higher in T2DM patients with macrovascular complications versus without, 
      suggesting T2DM patients in pro-inflammatory conditions. These results suggested 
      that irisin is protective, while RBP4 is a risk factor for T2DM macrovascular 
      complications.
FAU - Ali, Ehdaa Y
AU  - Ali EY
AD  - Biochemistry Department, Faculty of Science, University of Jeddah, Kingdom of 
      Saudi Arabia. E-mail. ehda-yousef777@hotmail.com.
FAU - Hegazy, Gehan A
AU  - Hegazy GA
FAU - Hashem, Enayat M
AU  - Hashem EM
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
RN  - 0 (Biomarkers)
RN  - 0 (FNDC5 protein, human)
RN  - 0 (Fibronectins)
RN  - 0 (Leptin)
RN  - 0 (RBP4 protein, human)
RN  - 0 (Retinol-Binding Proteins, Plasma)
SB  - IM
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Angiopathies/*diagnosis/*etiology/prevention & control
MH  - Female
MH  - Fibronectins/*blood
MH  - Humans
MH  - Leptin/*blood
MH  - Male
MH  - Middle Aged
MH  - *Retinol-Binding Proteins, Plasma
MH  - Risk Factors
MH  - Saudi Arabia
PMC - PMC7841592
EDAT- 2020/12/10 06:00
MHDA- 2021/04/23 06:00
PMCR- 2020/12/01
CRDT- 2020/12/09 06:17
PHST- 2020/12/09 06:17 [entrez]
PHST- 2020/12/10 06:00 [pubmed]
PHST- 2021/04/23 06:00 [medline]
PHST- 2020/12/01 00:00 [pmc-release]
AID - SaudiMedJ-41-1369 [pii]
AID - 10.15537/smj.2020.12.25461 [doi]
PST - ppublish
SO  - Saudi Med J. 2020 Dec;41(12):1369-1374. doi: 10.15537/smj.2020.12.25461.