PMID- 33295067
OWN - NLM
STAT- MEDLINE
DCOM- 20210701
LR  - 20221005
IS  - 2055-5822 (Electronic)
IS  - 2055-5822 (Linking)
VI  - 8
IP  - 1
DP  - 2021 Feb
TI  - Impaired cerebral oxygenation in heart failure patients at rest and during 
      head-up tilt testing.
PG  - 586-594
LID - 10.1002/ehf2.13128 [doi]
AB  - AIMS: Heart failure (HF) confers potentially negative effects on the brain and 
      autonomic nervous system. The measurement cerebral tissue oxygen saturation 
      (SctO(2) ) may aid in understanding such effects. We aimed to investigate if 
      compensated HF affects SctO(2) at rest and during orthostatic challenge. METHODS 
      AND RESULTS: Non-invasive haemodynamic monitoring and near-infrared spectroscopy 
      were applied during head-up tilt (HUT) in 61 HF patients [mean (SD) 71 (11) 
      years, 82% male, New York Heart Association (NYHA) class I-III] and 60 controls 
      [60 (12) years, 42% male). Group differences in continuous variables were 
      compared using Student's t-test. Associations between HF and SctO(2) were studied 
      using multivariable linear regression models adjusted for age, sex, diabetes, 
      smoking, systolic blood pressure (SBP), and heart rate in supine position and 
      after 10 min of HUT. Mean SctO(2) was lower in HF patients compared with controls 
      both in the supine position (67 vs. 71%; P < 0.001) and after 10 min of HUT (64 
      vs. 69%; P < 0.001). The HUT-induced SctO(2) decrease was greater in HF patients 
      compared with controls (P = 0.026). SBP did not change in neither HF patients nor 
      controls during HUT, whereas diastolic blood pressure and heart rate increased in 
      both groups. HF was associated with lower SctO(2) in supine (B = -2.5%, 
      P = 0.023) and after 10 min of HUT (B = -2.6%, P = 0.007) after multivariable 
      adjustments. CONCLUSIONS: Cerebral tissue oxygenation is lower in HF patients 
      both at rest and during orthostasis compared with subjects without HF. Future 
      studies should test if the lower cerebral oxygenation associates with negative 
      prognosis and with impaired cognitive function.
CI  - (c) 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on 
      behalf of European Society of Cardiology.
FAU - Kharraziha, Isabella
AU  - Kharraziha I
AD  - Department of Clinical Sciences, Lund University, Malmo, 20213, Sweden.
AD  - Department of Internal Medicine, Skane University Hospital, Malmo, Sweden.
FAU - Holm, Hannes
AU  - Holm H
AD  - Department of Clinical Sciences, Lund University, Malmo, 20213, Sweden.
AD  - Department of Cardiology, Skane University Hospital, Malmo, Sweden.
FAU - Magnusson, Martin
AU  - Magnusson M
AD  - Department of Clinical Sciences, Lund University, Malmo, 20213, Sweden.
AD  - Department of Cardiology, Skane University Hospital, Malmo, Sweden.
AD  - Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.
AD  - Hypertension in Africa Research Team (HART), North West University, 
      Potchefstroom, South Africa.
FAU - Wollmer, Per
AU  - Wollmer P
AD  - Department of Translational Medicine, Lund University, Malmo, Sweden.
AD  - Department of Medical Imaging and Physiology, Skane University Hospital, Malmo, 
      Sweden.
FAU - Molvin, John
AU  - Molvin J
AD  - Department of Clinical Sciences, Lund University, Malmo, 20213, Sweden.
AD  - Department of Cardiology, Skane University Hospital, Malmo, Sweden.
FAU - Jujic, Amra
AU  - Jujic A
AD  - Department of Clinical Sciences, Lund University, Malmo, 20213, Sweden.
AD  - Department of Cardiology, Skane University Hospital, Malmo, Sweden.
FAU - Fedorowski, Artur
AU  - Fedorowski A
AD  - Department of Clinical Sciences, Lund University, Malmo, 20213, Sweden.
AD  - Department of Cardiology, Skane University Hospital, Malmo, Sweden.
FAU - Bachus, Erasmus
AU  - Bachus E
AD  - Department of Clinical Sciences, Lund University, Malmo, 20213, Sweden.
FAU - Hamrefors, Viktor
AU  - Hamrefors V
AD  - Department of Clinical Sciences, Lund University, Malmo, 20213, Sweden.
AD  - Department of Internal Medicine, Skane University Hospital, Malmo, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201209
PL  - England
TA  - ESC Heart Fail
JT  - ESC heart failure
JID - 101669191
SB  - IM
MH  - Autonomic Nervous System
MH  - Blood Pressure
MH  - Female
MH  - *Heart Failure/diagnosis
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - *Tilt-Table Test
PMC - PMC7835614
OTO - NOTNLM
OT  - Cerebral oximetry
OT  - Head-up tilt test
OT  - Heart failure
OT  - Orthostatic provocation
COIS- P.W. reports personal fees from Chiesi Pharma outside the submitted work. A.F. 
      reports personal fees from Medtronic Inc. and Biotronik, and patent royalties 
      from Thermo Fisher Scientific outside the submitted work. E.B. has been employed 
      by AstraZeneca after completion of this study.
EDAT- 2020/12/10 06:00
MHDA- 2021/07/02 06:00
PMCR- 2020/12/09
CRDT- 2020/12/09 06:18
PHST- 2020/04/21 00:00 [received]
PHST- 2020/10/19 00:00 [revised]
PHST- 2020/11/11 00:00 [accepted]
PHST- 2020/12/10 06:00 [pubmed]
PHST- 2021/07/02 06:00 [medline]
PHST- 2020/12/09 06:18 [entrez]
PHST- 2020/12/09 00:00 [pmc-release]
AID - EHF213128 [pii]
AID - 10.1002/ehf2.13128 [doi]
PST - ppublish
SO  - ESC Heart Fail. 2021 Feb;8(1):586-594. doi: 10.1002/ehf2.13128. Epub 2020 Dec 9.