PMID- 33296865
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1876-2026 (Electronic)
IS  - 1876-2018 (Linking)
VI  - 55
DP  - 2021 Jan
TI  - Bi-temporal electroconvulsive therapy efficacy in bipolar and unipolar 
      depression: A retrospective comparison.
PG  - 102503
LID - S1876-2018(20)30616-X [pii]
LID - 10.1016/j.ajp.2020.102503 [doi]
AB  - AIM: Although electroconvulsive therapy (ECT) has been extensively used for 
      depressive episodes in bipolar disorder (BDD), it has received less interest in 
      research compared with major depressive disorder (MDD). Studies comparing the 
      efficacy of ECT in BDD and MDD have been contradictory. This study aimed to 
      compare the effectiveness of ECT in BDD and MDD, analyzing the influence of 
      clinical features on outcome. METHODS: The medical charts and electronic records 
      of 107 patients (MDDn = 75 [70.1 %], BDD n = 32 [29.9 %]) receiving bi-temporal 
      ECT were investigated retrospectively. Features of the index episode, such as the 
      time elapsed until ECT and the effect of diagnosis on efficacy evaluated by the 
      Hamilton Depression Rating Scale (HAM-D), were analyzed. RESULTS: The diagnostic 
      groups were alike concerning clinical features of the index episode, such as the 
      presence of psychotic symptoms and suicidality. Patient age and the number of 
      previous affective episodes were significantly different between the groups. The 
      time elapsed until ECT in the examined episode was significantly longer in the 
      MDD group. Compared with the MDD group, the BDD group had a significantly higher 
      remission rate with ECT. Regression analysis revealed that BDD diagnosis, older 
      age, and shorter time until ECT were significantly associated with remission. 
      CONCLUSION: The significant relationship observed between greater time elapsed 
      until ECT and worse outcome is noteworthy in terms of clinical practice. This 
      finding further challenges the widely accepted place of ECT as the "last resort" 
      for the treatment of depression in bipolar and unipolar affective disorders.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Gurel, S Can
AU  - Gurel SC
AD  - Department of Psychiatry, Hacettepe University Medical Faculty, Turkey; Brain 
      Stimulation and Cognition Group, Faculty of Psychology and Neuroscience, 
      Maastricht University, The Netherlands. Electronic address: 
      scgurel@hacettepe.edu.tr.
FAU - Mutlu, Emre
AU  - Mutlu E
AD  - Ministry of Health, Sehit Sait Erturk Etimesgut State Hospital, Turkey.
FAU - Basar, Koray
AU  - Basar K
AD  - Department of Psychiatry, Hacettepe University Medical Faculty, Turkey.
FAU - Yazici, M Kazim
AU  - Yazici MK
AD  - Department of Psychiatry, Hacettepe University Medical Faculty, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20201130
PL  - Netherlands
TA  - Asian J Psychiatr
JT  - Asian journal of psychiatry
JID - 101517820
SB  - IM
MH  - Aged
MH  - *Bipolar Disorder/therapy
MH  - *Depressive Disorder, Major/therapy
MH  - *Electroconvulsive Therapy
MH  - Humans
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Bipolar affective disorder
OT  - Electroconvulsive therapy
OT  - Major depressive disorder
OT  - Treatment outcome
OT  - Treatment-refractory depression
EDAT- 2020/12/10 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/12/09 20:10
PHST- 2020/08/16 00:00 [received]
PHST- 2020/10/21 00:00 [revised]
PHST- 2020/11/26 00:00 [accepted]
PHST- 2020/12/10 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/12/09 20:10 [entrez]
AID - S1876-2018(20)30616-X [pii]
AID - 10.1016/j.ajp.2020.102503 [doi]
PST - ppublish
SO  - Asian J Psychiatr. 2021 Jan;55:102503. doi: 10.1016/j.ajp.2020.102503. Epub 2020 
      Nov 30.