PMID- 33297039
OWN - NLM
STAT- MEDLINE
DCOM- 20201221
LR  - 20201221
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 263
DP  - 2021 Jan
TI  - An assessment of the estrogenic and androgenic properties of tetra- and 
      hexachloronaphthalene by YES/YAS in vitro assays.
PG  - 128006
LID - S0045-6535(20)32201-3 [pii]
LID - 10.1016/j.chemosphere.2020.128006 [doi]
AB  - Many persistent organic pollutants (POPs) exhibit endocrine disrupting activity 
      but studies on some POPs, e.g., polychlorinated naphthalenes (PCNs), are very 
      scarce. The present study investigates the (anti)estrogenic and (anti)androgenic 
      activities of 1,2,3,5,6,7-hexachloronaphthalane (PCN67) and 
      1,3,5,8-tetrachloronaphthalene (PCN43) using the yeast estrogen and androgen 
      reporter bioassays. Among the tested substances, antiestrogenic response was only 
      shown by PCN67. The strongest inhibition of estrogenic activity (up to 17.4%) was 
      observed in the low concentration ranges (5 pM - 0.5 nM) in the presence of 
      1.5 nM 17beta-estradiol. Both tested compounds showed partial estrogenic activity 
      with a hormetic-type response. However, both studied chemicals showed strong 
      antiandrogenic effects: their potency in the presence of 100 nM 17beta-testosterone 
      for PCN43 (IC50 = 2.59 muM) and PCN67 (IC50 = 3.14 muM) was approximately twice 
      that of the reference antiandrogen flutamide (IC50 = 6.14 muM). It cannot be 
      excluded that exposure to PCNs, together with other endocrine disrupting 
      chemicals (EDCs), may contribute to the deregulation of sex steroid hormone 
      signaling.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Stragierowicz, Joanna
AU  - Stragierowicz J
AD  - Department of Toxicology, Medical University of Lodz, Muszynskiego 1, 90-151, 
      Lodz, Poland.
FAU - Stypula-Trebas, Sylwia
AU  - Stypula-Trebas S
AD  - Department of Pharmacology and Toxicology, National Veterinary Research 
      Institute, Al. Partyzantow 57, 24-100, Pulawy, Poland.
FAU - Radko, Lidia
AU  - Radko L
AD  - Department of Pharmacology and Toxicology, National Veterinary Research 
      Institute, Al. Partyzantow 57, 24-100, Pulawy, Poland.
FAU - Posyniak, Andrzej
AU  - Posyniak A
AD  - Department of Pharmacology and Toxicology, National Veterinary Research 
      Institute, Al. Partyzantow 57, 24-100, Pulawy, Poland.
FAU - Nasiadek, Marzenna
AU  - Nasiadek M
AD  - Department of Toxicology, Medical University of Lodz, Muszynskiego 1, 90-151, 
      Lodz, Poland.
FAU - Klimczak, Michal
AU  - Klimczak M
AD  - Department of Toxicology, Medical University of Lodz, Muszynskiego 1, 90-151, 
      Lodz, Poland.
FAU - Kilanowicz, Anna
AU  - Kilanowicz A
AD  - Department of Toxicology, Medical University of Lodz, Muszynskiego 1, 90-151, 
      Lodz, Poland. Electronic address: anna.kilanowicz@umed.lodz.pl.
LA  - eng
PT  - Journal Article
DEP - 20200818
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Androgens)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Estrogens)
RN  - 0 (Naphthalenes)
RN  - 58877-88-6 (1,2,3,4,5,6-hexachloronaphthalene)
SB  - IM
MH  - *Androgens
MH  - *Endocrine Disruptors/toxicity
MH  - Estrogens
MH  - Naphthalenes
OTO - NOTNLM
OT  - Androgen
OT  - Endocrine disrupting chemicals
OT  - Estrogen
OT  - Polychlorinated naphthalenes
OT  - Yeast
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/12/11 06:00
MHDA- 2020/12/22 06:00
CRDT- 2020/12/10 01:01
PHST- 2020/06/03 00:00 [received]
PHST- 2020/07/31 00:00 [revised]
PHST- 2020/08/13 00:00 [accepted]
PHST- 2020/12/10 01:01 [entrez]
PHST- 2020/12/11 06:00 [pubmed]
PHST- 2020/12/22 06:00 [medline]
AID - S0045-6535(20)32201-3 [pii]
AID - 10.1016/j.chemosphere.2020.128006 [doi]
PST - ppublish
SO  - Chemosphere. 2021 Jan;263:128006. doi: 10.1016/j.chemosphere.2020.128006. Epub 
      2020 Aug 18.