PMID- 33297194
OWN - NLM
STAT- MEDLINE
DCOM- 20201221
LR  - 20201221
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 263
DP  - 2021 Jan
TI  - Factors associated with partitioning behavior of persistent organic pollutants in 
      a feto-maternal system: A multiple linear regression approach.
PG  - 128247
LID - S0045-6535(20)32442-5 [pii]
LID - 10.1016/j.chemosphere.2020.128247 [doi]
AB  - Prenatal exposure to persistent organic pollutants (POPs) has been a matter of 
      particular concern because such exposure can severely affect the health of the 
      fetus. The mechanistic understanding of the partitioning behavior of POPs in the 
      feto-maternal system and the associated factors, however, have rarely been 
      studied. Here, we employed a new approach based on multiple linear regression 
      (MLR) analysis to predict the feto-maternal ratio (FM-ratio) of POPs and to 
      assess the factors associated with feto-maternal partitioning behavior. Two 
      preliminary exploratory MLR models were built using physiological conditions of 
      the participants, and molecular descriptors were calculated with a computational 
      model. The FM-ratio was calculated from the concentrations of polychlorinated 
      biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs), and 
      polybrominated diphenyl ethers (PBDEs) in 20 pairs of maternal and cord blood. 
      The models showed that the lipids and cholesterols in the maternal and cord blood 
      and the placenta significantly influence the partitioning of POPs. The body mass 
      index (BMI) change during pregnancy was also related to the FM-ratio. The 
      physicochemical properties associated with lipophilicity and molecular size were 
      also related to the FM-ratio. Even though the results should be interpreted with 
      caution, the preliminary MLR models illustrate that feto-maternal partitioning is 
      governed by transplacental transporting mechanisms, toxicokinetics, and the 
      molecular physicochemical properties of POPs. Overall, the new approach used in 
      this study can improve our understanding of the partitioning behavior in the 
      feto-maternal system.
CI  - Copyright (c) 2020. Published by Elsevier Ltd.
FAU - Kim, Jun-Tae
AU  - Kim JT
AD  - Division of Environmental Science and Engineering, Pohang University of Science 
      and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, 37673, Republic of 
      Korea; Analysis and Assessment Center, Research Institute of Industrial Science 
      and Technology (RIST), San 32, Hyoja-dong, Nam-gu, Pohang, 37673, Republic of 
      Korea. Electronic address: jt0102@postech.ac.kr.
FAU - Oh, Dasom
AU  - Oh D
AD  - Division of Environmental Science and Engineering, Pohang University of Science 
      and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, 37673, Republic of 
      Korea.
FAU - Choi, Sung-Deuk
AU  - Choi SD
AD  - School of Urban and Environmental Engineering, Ulsan National Institute of 
      Science and Technology (UNIST), 50, UNIST-gil, Ulsan, 44919, Republic of Korea.
FAU - Chang, Yoon-Seok
AU  - Chang YS
AD  - Division of Environmental Science and Engineering, Pohang University of Science 
      and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, 37673, Republic of 
      Korea. Electronic address: yschang@postech.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20200904
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Dibenzofurans)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Dibenzofurans
MH  - *Environmental Pollutants/analysis
MH  - Female
MH  - Halogenated Diphenyl Ethers/analysis
MH  - Humans
MH  - Linear Models
MH  - Persistent Organic Pollutants
MH  - *Polychlorinated Biphenyls/analysis
MH  - *Polychlorinated Dibenzodioxins/analysis
MH  - Pregnancy
OTO - NOTNLM
OT  - Feto-maternal partitioning
OT  - Multiple linear regression
OT  - Persistent organic pollutants
OT  - Prenatal exposure
OT  - Transplacental transport
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/12/11 06:00
MHDA- 2020/12/22 06:00
CRDT- 2020/12/10 01:02
PHST- 2020/06/02 00:00 [received]
PHST- 2020/08/15 00:00 [revised]
PHST- 2020/09/01 00:00 [accepted]
PHST- 2020/12/10 01:02 [entrez]
PHST- 2020/12/11 06:00 [pubmed]
PHST- 2020/12/22 06:00 [medline]
AID - S0045-6535(20)32442-5 [pii]
AID - 10.1016/j.chemosphere.2020.128247 [doi]
PST - ppublish
SO  - Chemosphere. 2021 Jan;263:128247. doi: 10.1016/j.chemosphere.2020.128247. Epub 
      2020 Sep 4.