PMID- 33297727
OWN - NLM
STAT- MEDLINE
DCOM- 20210906
LR  - 20211001
IS  - 1526-2359 (Electronic)
IS  - 1073-2748 (Print)
IS  - 1073-2748 (Linking)
VI  - 27
IP  - 1
DP  - 2020 Jan-Dec
TI  - Prognostic Significance of Lactate Dehydrogenase in Patients Undergoing Surgical 
      Resection for Laryngeal Squamous Cell Carcinoma.
PG  - 1073274820978795
LID - 10.1177/1073274820978795 [doi]
LID - 1073274820978795
AB  - The aim is to estimate the prognostic value of lactate dehydrogenase (LDH) in 
      patients undergoing surgical resection for laryngeal squamous cell carcinoma 
      (LSCC). A total of 640 resected LSCC patients were included. Preoperative lactate 
      dehydrogenase (LDH) was assessed. Kaplan-Meier survival analysis and Cox 
      regression analysis were conducted for overall survival (OS) and recurrence-free 
      survival (RFS). Kaplan-Meier analysis, univariate analysis and multivariate 
      analysis demonstrated significant prognostic value for preoperative LDH. Although 
      LDH was predictor of OS, it failed to be a predictor of RFS. The univariate HR 
      and 95% CI of LDH were 0.484 and 0.357-0.658 (P < 0.0001). The multivariate 
      analysis showed that LDH (HR = 0.518, 95% CI: 0.380-0.705, p < 0.0001) was 
      related to OS. Elevated preoperative LDH >132 IU/L was significantly associated 
      with better survival. Preoperative LDH might be an independent prognostic marker 
      of OS in LSCC patients undergoing surgical resection.
FAU - Guo, Erliang
AU  - Guo E
AD  - Department of Surgery, The 2nd Affiliated Hospital of Harbin Medical University, 
      Harbin 150081, China.
AD  - *  These two authors have contributed equally to the work.
FAU - Guo, Lunhua
AU  - Guo L
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin 150081, China.
AD  - *  These two authors have contributed equally to the work.
FAU - An, Changming
AU  - An C
AD  - Department of Head and Neck Surgery, Chinese National Cancer Center & Chinese 
      Academy of Medical Sciences Cancer Hospital. Beijing 100000, China.
FAU - Zhang, Cong
AU  - Zhang C
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin 150081, China.
FAU - Song, Kaibin
AU  - Song K
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin 150081, China.
FAU - Wang, Guohui
AU  - Wang G
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin 150081, China.
FAU - Duan, Chunbin
AU  - Duan C
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin 150081, China.
FAU - Zhang, Xiwei
AU  - Zhang X
AD  - Department of Head and Neck Surgery, Chinese National Cancer Center & Chinese 
      Academy of Medical Sciences Cancer Hospital. Beijing 100000, China.
FAU - Yang, Xianguang
AU  - Yang X
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin 150081, China.
FAU - Yuan, Zhennan
AU  - Yuan Z
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin 150081, China.
FAU - Guo, Junnan
AU  - Guo J
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin 150081, China.
FAU - Sun, Ji
AU  - Sun J
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin 150081, China.
FAU - Meng, Hongxue
AU  - Meng H
AD  - Department of Pathology, Harbin Medical University Cancer Hospital, Harbin 
      150081, China.
FAU - Chang, Rui
AU  - Chang R
AD  - Department of Head and Neck Surgery, Anyang Cancer Hospital, Anyang 455000, 
      China.
FAU - Li, Xiaomei
AU  - Li X
AD  - Department of Pathology, Harbin Medical University Cancer Hospital, Harbin 
      150081, China.
FAU - Xiu, Cheng
AU  - Xiu C
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin 150081, China.
FAU - Mao, Xionghui
AU  - Mao X
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin 150081, China.
FAU - Miao, Susheng
AU  - Miao S
AUID- ORCID: 0000-0002-7701-9362
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin 150081, China.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Cancer Control
JT  - Cancer control : journal of the Moffitt Cancer Center
JID - 9438457
RN  - 0 (Biomarkers, Tumor)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/*blood
MH  - Disease-Free Survival
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - L-Lactate Dehydrogenase/*blood
MH  - Laryngeal Neoplasms/blood/*mortality/surgery
MH  - Laryngectomy/statistics & numerical data
MH  - Larynx/pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*epidemiology/prevention & control
MH  - Predictive Value of Tests
MH  - Preoperative Period
MH  - Prognosis
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Risk Assessment/methods/statistics & numerical data
MH  - Squamous Cell Carcinoma of Head and Neck/blood/*mortality/surgery
PMC - PMC8480349
OTO - NOTNLM
OT  - lactate dehydrogenase
OT  - laryngeal cancer
OT  - overall survival
OT  - prognosis
OT  - recurrence-free survival
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2020/12/11 06:00
MHDA- 2021/09/07 06:00
PMCR- 2020/12/09
CRDT- 2020/12/10 05:33
PHST- 2020/12/10 05:33 [entrez]
PHST- 2020/12/11 06:00 [pubmed]
PHST- 2021/09/07 06:00 [medline]
PHST- 2020/12/09 00:00 [pmc-release]
AID - 10.1177_1073274820978795 [pii]
AID - 10.1177/1073274820978795 [doi]
PST - ppublish
SO  - Cancer Control. 2020 Jan-Dec;27(1):1073274820978795. doi: 
      10.1177/1073274820978795.