PMID- 33297914
OWN - NLM
STAT- MEDLINE
DCOM- 20220228
LR  - 20220228
IS  - 1875-5666 (Electronic)
IS  - 1566-5240 (Linking)
VI  - 21
IP  - 7
DP  - 2021
TI  - Extracellular Vesicles in Tumor Diagnosis: A Mini-Review.
PG  - 596-606
LID - 10.2174/1573405616666201209103154 [doi]
AB  - Wide exploration of noninvasive tumor/cancer biomarkers has shed light on 
      clinical diagnosis. However, many under-investigated biomarkers showed limited 
      application potency due to low sensitivity and specificity, while extracellular 
      vehicles (EVs) were gradually recognized as promising candidates. EVs are small 
      vesicles transporting bioactive cargos between cells in multiple physiological 
      processes and also in tumor/cancer pathogenesis. This review aimed to offer 
      recent studies of EVs on structure, classification, physiological functions, as 
      well as changes in tumor initiation and progression. Furthermore, we focused on 
      advances of EVs and/or EV-related substances in cancer diagnosis, and summarized 
      ongoing studies of promising candidates for future investigations.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Yu, Si
AU  - Yu S
AD  - Department of Liver Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
FAU - Huang, Menglin
AU  - Huang M
AD  - Department of Liver Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
FAU - Wang, Jingyu
AU  - Wang J
AD  - Department of Liver Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
FAU - Zheng, Yongchang
AU  - Zheng Y
AD  - Department of Liver Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
FAU - Xu, Haifeng
AU  - Xu H
AD  - Department of Liver Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
LA  - eng
GR  - CFHPC 2020021/WBE Liver Fibrosis Foundation-Beijing Dongcheng District 
      outstanding talent funding project/
GR  - 18JR3RA029/Natural Science Foundation of Gansu Province/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Curr Mol Med
JT  - Current molecular medicine
JID - 101093076
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/*metabolism
MH  - *Cell Communication
MH  - Extracellular Vesicles/*metabolism
MH  - Humans
MH  - *Neoplasms/diagnosis/metabolism
OTO - NOTNLM
OT  - Extracellular vesicle
OT  - biomarker
OT  - cancer diagnosis
OT  - exosome
OT  - microvesicles.
OT  - tumor microenvironment
EDAT- 2020/12/11 06:00
MHDA- 2022/03/01 06:00
CRDT- 2020/12/10 05:35
PHST- 2020/05/06 00:00 [received]
PHST- 2020/08/04 00:00 [revised]
PHST- 2020/11/25 00:00 [accepted]
PHST- 2020/12/11 06:00 [pubmed]
PHST- 2022/03/01 06:00 [medline]
PHST- 2020/12/10 05:35 [entrez]
AID - CMM-EPUB-112219 [pii]
AID - 10.2174/1573405616666201209103154 [doi]
PST - ppublish
SO  - Curr Mol Med. 2021;21(7):596-606. doi: 10.2174/1573405616666201209103154.