PMID- 33298050 OWN - NLM STAT- MEDLINE DCOM- 20210928 LR - 20210928 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 20 IP - 1 DP - 2020 Dec 9 TI - Lipid accumulation product (LAP) was independently associatedwith obstructive sleep apnea in patients with type 2 diabetes mellitus. PG - 179 LID - 10.1186/s12902-020-00661-x [doi] LID - 179 AB - BACKGROUND: Lipid accumulation product (LAP) is a new index based on a combination of waist circumference (WC) and serum triglycerides (TG) reflecting lipid accumulation. In this cross-sectional study, we aimed to explore whether LAP was independently associated with obstructive sleep apnea (OSA) in Type 2 diabetes mellitus (T2DM) patients. METHODS: A cross-sectional study of 317 T2DM patients who underwent overnight polysomnography (PSG) tests was conducted. The clinical data between non-OSA group and OSA group were compared. Multivariable linear regression and multivariable logistic regression analyses were performed to determine associations of LAP, with apnea-hypopnea index (AHI) and OSA. RESULTS: Among 317 patients, 219 (69.1%) were men, and the mean ages (+/-SD) were 51.4 (+/-13.5) years for men and 54.6 (+/-15.1) years for women (p = 0.067). The prevalence rates of OSA were 63.0% for men and 68.4% for women (p = 0.357). LAP (log-transformed) was significantly correlated with AHI (log-transformed), with the Pearson's correlation coefficient of 0.170 (p = 0.002). With adjustment for potential confounding factors, multivariate linear regression analyses showed the association of LAP with AHI was not statistically significant, with the adjusted linear regression coefficients (95% CI) of per SD increase of LAP for AHI (log-transformed) was 0.092 (- 0.011-0.194, p = 0.080). Multivariate logistic regression analyses showed LAP was significantly associated with increased risk of OSA, with the adjusted OR (95%CI) of per SD increase of LAP of 1.639 (1.032-2.604, p = 0.036). However, as constituents of LAP, neither TG nor WC was significantly associated with AHI and OSA. CONCLUSION: LAP was independently associated with OSA and might be used as a potential OSA risk marker in T2DM patients, beyond the general index of obesity. FAU - Dong, Lianqin AU - Dong L AD - The School of Clinical Medicine, Fujian Medical University, Fuzhou, 350000, China. FAU - Lin, Mingzhu AU - Lin M AD - Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, No.55 Zhenhai Road, Xaimen, 361003, China. AD - Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Fujian Province Key Laboratory of Diabetes Translational Medicine, Xiamen, China. FAU - Wang, Wengui AU - Wang W AD - Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, No.55 Zhenhai Road, Xaimen, 361003, China. FAU - Ma, Danyan AU - Ma D AD - School of Medicine, Xiamen University, Xiamen, China. FAU - Chen, Yun AU - Chen Y AD - The School of Clinical Medicine, Fujian Medical University, Fuzhou, 350000, China. FAU - Su, Weijuan AU - Su W AD - Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, No.55 Zhenhai Road, Xaimen, 361003, China. AD - Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Fujian Province Key Laboratory of Diabetes Translational Medicine, Xiamen, China. FAU - Chen, Zheng AU - Chen Z AD - Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, No.55 Zhenhai Road, Xaimen, 361003, China. AD - Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Fujian Province Key Laboratory of Diabetes Translational Medicine, Xiamen, China. FAU - Wang, Shunhua AU - Wang S AD - Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, No.55 Zhenhai Road, Xaimen, 361003, China. AD - Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Fujian Province Key Laboratory of Diabetes Translational Medicine, Xiamen, China. FAU - Li, Xuejun AU - Li X AD - Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, No.55 Zhenhai Road, Xaimen, 361003, China. AD - Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Fujian Province Key Laboratory of Diabetes Translational Medicine, Xiamen, China. FAU - Li, Zhibin AU - Li Z AD - Epidemiology Research Unit, The First Affiliated Hospital of Xiamen University, No.55 Zhenhai Road, Xiamen, 361003, China. zhibinli33@hotmail.com. FAU - Liu, Changqin AU - Liu C AUID- ORCID: 0000-0001-8063-7906 AD - The School of Clinical Medicine, Fujian Medical University, Fuzhou, 350000, China. liuchangqin@xmu.edu.cn. AD - Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, No.55 Zhenhai Road, Xaimen, 361003, China. liuchangqin@xmu.edu.cn. AD - Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Fujian Province Key Laboratory of Diabetes Translational Medicine, Xiamen, China. liuchangqin@xmu.edu.cn. LA - eng GR - 2017J01365/the natural science foundation of Fujian province/ GR - 81870611/the natural science foundation of China/ PT - Journal Article DEP - 20201209 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 RN - 0 (Triglycerides) SB - IM MH - Adult MH - Aged MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/*blood/*diagnosis/epidemiology MH - Female MH - Humans MH - Lipid Accumulation Product/*physiology MH - Male MH - Middle Aged MH - Polysomnography/methods MH - Sleep Apnea, Obstructive/*blood/*diagnosis/epidemiology MH - Triglycerides/blood MH - Waist Circumference/physiology PMC - PMC7727244 OTO - NOTNLM OT - Apnea-hypopnea index OT - Lipid accumulation product OT - Obstructive sleep apnea OT - Type 2 diabetes mellitus COIS- The authors declare that they have no competing interests. EDAT- 2020/12/11 06:00 MHDA- 2021/09/29 06:00 PMCR- 2020/12/09 CRDT- 2020/12/10 05:36 PHST- 2020/07/19 00:00 [received] PHST- 2020/12/03 00:00 [accepted] PHST- 2020/12/10 05:36 [entrez] PHST- 2020/12/11 06:00 [pubmed] PHST- 2021/09/29 06:00 [medline] PHST- 2020/12/09 00:00 [pmc-release] AID - 10.1186/s12902-020-00661-x [pii] AID - 661 [pii] AID - 10.1186/s12902-020-00661-x [doi] PST - epublish SO - BMC Endocr Disord. 2020 Dec 9;20(1):179. doi: 10.1186/s12902-020-00661-x.