PMID- 33298657
OWN - NLM
STAT- MEDLINE
DCOM- 20210202
LR  - 20210202
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 61
IP  - 11
DP  - 2020
TI  - [Multiple myeloma with light chain deposition disease showing needle-like crystal 
      inclusions in plasma cells and macrophages in multiple organs].
PG  - 1620-1624
LID - 10.11406/rinketsu.61.1620 [doi]
AB  - A 57-year-old Japanese man was referred to our hospital with the chief complaint 
      of dizziness. Our investigations showed pancytopenia that necessitated bone 
      marrow evaluation; this evaluation revealed plasma cell proliferation that was 
      accompanied by numerous needle-shaped crystal inclusions. Clinical and laboratory 
      examinations were used to establish a diagnosis of multiple myeloma (MM) 
      accompanied by Fanconi syndrome. He was administered treatment with bortezomib, 
      lenalidomide, or thalidomide; however, he died after experiencing upper abdominal 
      pain of unknown etiology. Histopathological examination showed needle-like 
      inclusions in the liver and kidney and macrophages in the bone marrow, suggesting 
      light chain deposition disease (LCDD) that could contribute to multi-organ 
      injury. We report the rare case of a patient with needle-shaped inclusions in MM 
      that caused LCDD.
FAU - Ohara, Shin
AU  - Ohara S
AD  - Internal Medicine, Eiju General Hospital.
FAU - Ide, Shiro
AU  - Ide S
AD  - Internal Medicine, Eiju General Hospital.
FAU - Uchida, Tomoyuki
AU  - Uchida T
AD  - Internal Medicine, Eiju General Hospital.
FAU - Inoue, Morihiro
AU  - Inoue M
AD  - Internal Medicine, Eiju General Hospital.
FAU - Hua, Jian
AU  - Hua J
AD  - Internal Medicine, Eiju General Hospital.
FAU - Hagihara, Masao
AU  - Hagihara M
AD  - Internal Medicine, Eiju General Hospital.
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - 4Z8R6ORS6L (Thalidomide)
RN  - F0P408N6V4 (Lenalidomide)
SB  - IM
MH  - Humans
MH  - Lenalidomide
MH  - Macrophages
MH  - Male
MH  - Middle Aged
MH  - *Multiple Myeloma/drug therapy
MH  - Plasma Cells
MH  - Thalidomide
OTO - NOTNLM
OT  - Crystal inclusion
OT  - Fanconi syndrome
OT  - Light chain deposition disease
OT  - Multiple myeloma
EDAT- 2020/12/11 06:00
MHDA- 2021/02/03 06:00
CRDT- 2020/12/10 05:42
PHST- 2020/12/10 05:42 [entrez]
PHST- 2020/12/11 06:00 [pubmed]
PHST- 2021/02/03 06:00 [medline]
AID - 10.11406/rinketsu.61.1620 [doi]
PST - ppublish
SO  - Rinsho Ketsueki. 2020;61(11):1620-1624. doi: 10.11406/rinketsu.61.1620.