PMID- 33299497
OWN - NLM
STAT- MEDLINE
DCOM- 20210819
LR  - 20220418
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2020
DP  - 2020
TI  - Serum TNF-alpha Level Is Associated with Disease Severity in Adult Patients with 
      Immunoglobulin A Vasculitis Nephritis.
PG  - 5514145
LID - 10.1155/2020/5514145 [doi]
LID - 5514145
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory factor involved 
      in the pathogenesis of immunoglobulin A vasculitis (IgAV). The association 
      between serum TNF-alpha and disease severity in adult patients with IgAV nephritis 
      (IgAV-N) has been inadequately evaluated. METHODS: Serum TNF-alpha was measured by 
      chemiluminescence immunoassay in 53 renal biopsy-proved IgAV-N patients, 53 
      healthy controls, and 53 IgA nephropathy (IgAN) patients. The correlations of 
      clinicopathologic parameters of IgAV-N patients with serum TNF-alpha were analyzed. 
      RESULTS: In this cross-sectional study, the median age of IgAV-N patients was 29 
      (25-37) years, and 67.9% were female. Serum TNF-alpha was significantly higher in the 
      IgAV-N group than in the healthy group [7.4 (5.7-9.4) pg/mL vs. 5.9 (5.0, 
      7.1) pg/mL, P = 0.001], but comparable with sex, age, and estimated glomerular 
      filtration rate (eGFR) grade-matched IgAN patients. Serum creatinine (P = 0.006) 
      and serum cystatin C (P = 0.001) were positively correlated with serum TNF-alpha 
      level, while albumin (P = 0.014) and eGFR (P = 0.021) were negatively correlated 
      with serum TNF-alpha level. Multivariate linear regression analysis revealed that 
      eGFR (P = 0.007) was an independent clinical predictor of serum TNF-alpha. Patients 
      with higher pathological classification grade also had higher serum TNF-alpha. 
      CONCLUSIONS: Serum TNF-alpha is associated with renal function and the pathological 
      classification of adult patients with IgAV-N. TNF-alpha is a potential biomarker for 
      the assessment of IgAV-N severity.
CI  - Copyright (c) 2020 Haiting Wu et al.
FAU - Wu, Haiting
AU  - Wu H
AUID- ORCID: 0000-0001-5725-021X
AD  - Division of Nephrology, Department of Internal Medicine, Peking Union Medical 
      College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing 100730, China.
FAU - Wen, Yubing
AU  - Wen Y
AUID- ORCID: 0000-0003-0438-8447
AD  - Division of Nephrology, Department of Internal Medicine, Peking Union Medical 
      College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing 100730, China.
FAU - Yue, Cai
AU  - Yue C
AUID- ORCID: 0000-0001-5754-0225
AD  - Division of Nephrology, Department of Internal Medicine, Peking Union Medical 
      College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing 100730, China.
FAU - Li, Xuemei
AU  - Li X
AUID- ORCID: 0000-0002-5966-6240
AD  - Division of Nephrology, Department of Internal Medicine, Peking Union Medical 
      College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing 100730, China.
FAU - Gao, Ruitong
AU  - Gao R
AUID- ORCID: 0000-0002-2117-5032
AD  - Division of Nephrology, Department of Internal Medicine, Peking Union Medical 
      College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing 100730, China.
LA  - eng
PT  - Journal Article
DEP - 20201125
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Biomarkers)
RN  - 0 (CST3 protein, human)
RN  - 0 (Cystatin C)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Biomarkers/*blood
MH  - Case-Control Studies
MH  - Creatinine/blood
MH  - Cross-Sectional Studies
MH  - Cystatin C/blood
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Glomerulonephritis, IGA/blood/metabolism/*physiopathology
MH  - Humans
MH  - Linear Models
MH  - Luminescent Measurements
MH  - Male
MH  - Severity of Illness Index
MH  - Tumor Necrosis Factor-alpha/*blood
MH  - *Up-Regulation
MH  - Vasculitis/blood/metabolism/*physiopathology
MH  - Young Adult
PMC - PMC7710402
COIS- The authors declare no conflict of interest related to this study.
EDAT- 2020/12/11 06:00
MHDA- 2021/08/20 06:00
PMCR- 2020/11/25
CRDT- 2020/12/10 05:57
PHST- 2020/02/22 00:00 [received]
PHST- 2020/11/08 00:00 [revised]
PHST- 2020/11/17 00:00 [accepted]
PHST- 2020/12/10 05:57 [entrez]
PHST- 2020/12/11 06:00 [pubmed]
PHST- 2021/08/20 06:00 [medline]
PHST- 2020/11/25 00:00 [pmc-release]
AID - 10.1155/2020/5514145 [doi]
PST - epublish
SO  - Dis Markers. 2020 Nov 25;2020:5514145. doi: 10.1155/2020/5514145. eCollection 
      2020.