PMID- 33301666 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211113 IS - 1738-3684 (Print) IS - 1976-3026 (Electronic) IS - 1738-3684 (Linking) VI - 17 IP - 12 DP - 2020 Dec TI - Impaired Performance on the Reading the Mind in the Eyes Test in First-Episode Psychosis and Clinical High Risk for Psychosis. PG - 1200-1206 LID - 10.30773/pi.2020.0264 [doi] AB - OBJECTIVE: Although previous studies have reported impaired performance in the reading the mind in the eyes test (RMET), which measures complex emotion recognition abilities, in patients with schizophrenia, reports regarding individuals at clinical high risk (CHR) for psychosis have been inconsistent, mainly due to the interacting confounding effects of general cognitive abilities and age. We compared RMET performances across first-episode psychosis (FEP) patients, CHR individuals, and healthy controls (HCs) while controlling for the effects of both general cognitive abilities and age. METHODS: A total of 25 FEP, 41 CHR, and 44 HC subjects matched for age participated in this study. RMET performance scores were compared across the groups using analysis of variance with sex and intelligence quotient as covariates. Exploratory Pearson's correlation analyses were performed to reveal the potential relationships of RMET scores with clinical symptom severity in the FEP and CHR groups. RESULTS: RMET performance scores were significantly lower among FEP and CHR participants than among HCs. FEP patients and CHR subjects showed comparable RMET performance scores. RMET scores were negatively correlated with Positive and Negative Syndrome Scale (PANSS) positive symptom subscale scores in the FEP patients. No significant correlation was identified between RMET scores and other clinical scale scores. CONCLUSION: Impaired RMET performance is present from the risk stage of psychosis, which might be related to positive symptom severity in early psychosis. Longitudinal studies are necessary to confirm the stability of complex emotion recognition impairments and their relationship with social functioning in early psychosis patients. FAU - Kim, Seo Woo AU - Kim SW AD - Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea. FAU - Moon, Sun-Young AU - Moon SY AD - Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. AD - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. FAU - Hwang, Wu Jeong AU - Hwang WJ AD - Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea. FAU - Lho, Silvia Kyungjin AU - Lho SK AD - Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. AD - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. FAU - Oh, Sanghoon AU - Oh S AD - Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. AD - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. FAU - Lee, Tae Young AU - Lee TY AD - Department of Neuropsychiatry, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea. AD - Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea. FAU - Kim, Minah AU - Kim M AD - Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. AD - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. FAU - Kwon, Jun Soo AU - Kwon JS AD - Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. AD - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. AD - Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea. LA - eng PT - Journal Article DEP - 20201211 PL - Korea (South) TA - Psychiatry Investig JT - Psychiatry investigation JID - 101242994 PMC - PMC8560336 OTO - NOTNLM OT - Clinical high risk for psychosis OT - First-episode psychosis OT - Reading the mind in the eyes test OT - Schizophrenia OT - Theory of mind COIS- The authors have no potential conflicts of interest to disclose. EDAT- 2020/12/11 06:00 MHDA- 2020/12/11 06:01 PMCR- 2020/12/01 CRDT- 2020/12/10 18:55 PHST- 2020/07/08 00:00 [received] PHST- 2020/09/23 00:00 [accepted] PHST- 2020/12/11 06:00 [pubmed] PHST- 2020/12/11 06:01 [medline] PHST- 2020/12/10 18:55 [entrez] PHST- 2020/12/01 00:00 [pmc-release] AID - pi.2020.0264 [pii] AID - pi-2020-0264 [pii] AID - 10.30773/pi.2020.0264 [doi] PST - ppublish SO - Psychiatry Investig. 2020 Dec;17(12):1200-1206. doi: 10.30773/pi.2020.0264. Epub 2020 Dec 11.