PMID- 33302270
OWN - NLM
STAT- MEDLINE
DCOM- 20210916
LR  - 20210916
IS  - 2504-2106 (Electronic)
IS  - 2504-2092 (Linking)
VI  - 28
IP  - 3
DP  - 2021
TI  - Efficacy of Pomegranate Seed Powder on Glucose and Lipid Metabolism in Patients 
      with Type 2 Diabetes: A Prospective Randomized Double-Blind Placebo-Controlled 
      Clinical Trial.
PG  - 226-233
LID - 10.1159/000510986 [doi]
AB  - INTRODUCTION: Pomegranate is known as a functional food which has multiple 
      health-promoting activities. It has been assessed for patients with metabolic 
      syndrome. Specifically, an antidiabetic activity of its juice and plausible 
      mechanisms for its action have been shown in multitudinous studies. The aim of 
      this study was assessing the effects of complementary treatment with pomegranate 
      seed powder (PSP) oral supplementation on patients with type 2 diabetes mellitus 
      (T2DM). METHODS: Sixty patients were treated for 8 weeks by 5 g PSP or placebo, 
      twice daily. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total 
      cholesterol, and triglyceride (TG) were recorded as the outcome measures at the 
      beginning and after the intervention. The findings were analyzed using the 
      independent t test and Mann-Whitney U test. RESULTS: After 8 weeks, the mean 
      differences of FBG, HbA1c, cholesterol, and TG were significantly decreased in 
      the PSP group when compared with the placebo group (p value <0.05). In addition, 
      post-intervention values of FBG and HbA1c were significantly lower in patients 
      treated with PSP compared to the placebo group (p values = 0.02 and 0.01, 
      respectively). However, the latter comparison regarding cholesterol and TG showed 
      no significant differences (p values = 0.51 and 0.26, respectively). CONCLUSION: 
      It seems that complementary treatment with PSP may have beneficial effects on FBG 
      and HbA1c of patients with T2DM. However, its effect on TG and cholesterol was 
      equivocal.
CI  - (c) 2020 S. Karger AG, Basel.
FAU - Seyed Hashemi, Monire
AU  - Seyed Hashemi M
AD  - Department of Persian Medicine, The School of Persian Medicine, Shahid Sadoughi 
      University of Medical Sciences, Yazd, Iran.
FAU - Namiranian, Nasim
AU  - Namiranian N
AD  - Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
FAU - Tavahen, Hemaseh
AU  - Tavahen H
AD  - Department of Persian Medicine, The School of Persian Medicine, Shahid Sadoughi 
      University of Medical Sciences, Yazd, Iran.
FAU - Dehghanpour, Abolfazl
AU  - Dehghanpour A
AD  - Department of Persian Medicine, The School of Persian Medicine, Shahid Sadoughi 
      University of Medical Sciences, Yazd, Iran.
FAU - Rad, Mohammad Hadi
AU  - Rad MH
AD  - Agricultural and Natural Resource Research and Education Center, Agriculture 
      Research Education and Extension Organization (AREEO), Yazd, Iran.
FAU - Jam-Ashkezari, Saeedeh
AU  - Jam-Ashkezari S
AD  - Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
FAU - Emtiazy, Majid
AU  - Emtiazy M
AD  - Department of Persian Medicine, The School of Persian Medicine, Shahid Sadoughi 
      University of Medical Sciences, Yazd, Iran.
AD  - Research Center of Persian Medicine, Shahid Sadoughi University of Medical 
      Sciences, Yazd, Iran.
FAU - Hashempur, Mohammad Hashem
AU  - Hashempur MH
AD  - Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, 
      Fasa, Iran, hashempur@gmail.com.
AD  - Department of Persian Medicine, Fasa University of Medical Sciences, Fasa, Iran, 
      hashempur@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - Wirksamkeit von Granatapfelkern-Pulver im Hinblick auf Glukose- und 
      Lipidstoffwechsel bei Patienten mit Typ-2-Diabetes: Eine prospektive, 
      randomisierte, doppelblinde, plazebokontrollierte klinische Studie.
DEP - 20201210
PL  - Switzerland
TA  - Complement Med Res
JT  - Complementary medicine research
JID - 101698453
RN  - 0 (Blood Glucose)
RN  - 0 (Plant Preparations)
RN  - 0 (Powders)
SB  - IM
MH  - Blood Glucose/*metabolism
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Humans
MH  - Lipid Metabolism/*drug effects
MH  - Plant Preparations/*therapeutic use
MH  - *Pomegranate
MH  - Powders
MH  - Prospective Studies
MH  - Seeds
OTO - NOTNLM
OT  - Cholesterol
OT  - Complementary medicine
OT  - Glycemic indices
OT  - Pomegranate seed
OT  - Punica granatum
OT  - Traditional Persian medicine
OT  - Triglyceride
OT  - Type 2 diabetes mellitus
EDAT- 2020/12/11 06:00
MHDA- 2021/09/18 06:00
CRDT- 2020/12/10 20:15
PHST- 2020/04/22 00:00 [received]
PHST- 2020/08/16 00:00 [accepted]
PHST- 2020/12/11 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2020/12/10 20:15 [entrez]
AID - 000510986 [pii]
AID - 10.1159/000510986 [doi]
PST - ppublish
SO  - Complement Med Res. 2021;28(3):226-233. doi: 10.1159/000510986. Epub 2020 Dec 10.