PMID- 33303058
OWN - NLM
STAT- MEDLINE
DCOM- 20210907
LR  - 20210907
IS  - 0031-7144 (Print)
IS  - 0031-7144 (Linking)
VI  - 75
IP  - 12
DP  - 2020 Dec 1
TI  - SIRT4 expression in laryngeal squamous cell carcinoma.
PG  - 646-650
LID - 10.1691/ph.2020.0734 [doi]
AB  - SIRT4 has been reported to be abnormally expressed in many malignant tumor 
      tissues, but data in laryngeal squamous cell carcinoma (LSCC) is lacking. In the 
      present study, we detected the expression of SIRT4 in 168 pairs of LSCC tissues 
      and adjacent normal tissues using RT-qPCR, immunoblotting and immunohistochemical 
      staining, and analyzed its clinical implication. We found that SIRT4 expression 
      was low in LSCC tissues, and was significantly related to histological grade, T 
      classification, clinical stage, lymph node metastasis and recurrence of LSCC 
      patients. In vitro, knockdown of SIRT4 promoted the proliferation and migration 
      of LSCC cells, while overexpression of SIRT4 inhibits the proliferation and 
      migration of LSCC cells. Moreover, the expression of SIRT4 protein was an 
      independent factor affecting the disease-free survival (DFS) (HR=0.562, 
      95%CI=0.1290.834) and overall survival rates (OS) (HR=0.628, 95%CI=0.267-0.935) 
      of LSCC patients. The 5-years DFS and OS in LSCC patients with low SIRT4 
      expression were significantly lower than that in LSCC patients with high SIRT4 
      expression. In conclusion, SIRT4 was lowly expressed in LSCC patients, which 
      might be related to more aggressive tumor behaviour and a poor prognosis.
FAU - Wan, Wuhanhui
AU  - Wan W
FAU - Li, Yanni
AU  - Li Y
FAU - Zhou, Chengyong
AU  - Zhou C
FAU - Sun, Baochun
AU  - Sun B
FAU - Yang, Shuzhi
AU  - Yang S
FAU - Zhou, Chengyong
AU  - Zhou C
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pharmazie
JT  - Die Pharmazie
JID - 9800766
RN  - 0 (Mitochondrial Proteins)
RN  - EC 3.5.1.- (SIRT4 protein, human)
RN  - EC 3.5.1.- (Sirtuins)
SB  - IM
MH  - Cell Proliferation
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/*metabolism/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Mitochondrial Proteins/*metabolism
MH  - Neoplasm Metastasis
MH  - Sirtuins/*metabolism
MH  - Squamous Cell Carcinoma of Head and Neck/genetics/*metabolism/mortality/pathology
EDAT- 2020/12/12 06:00
MHDA- 2021/09/08 06:00
CRDT- 2020/12/11 05:37
PHST- 2020/12/11 05:37 [entrez]
PHST- 2020/12/12 06:00 [pubmed]
PHST- 2021/09/08 06:00 [medline]
AID - 10.1691/ph.2020.0734 [doi]
PST - ppublish
SO  - Pharmazie. 2020 Dec 1;75(12):646-650. doi: 10.1691/ph.2020.0734.