PMID- 33303194
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20211008
LR  - 20211008
IS  - 2173-5077 (Electronic)
IS  - 2173-5077 (Linking)
VI  - 99
IP  - 3
DP  - 2021 Mar
TI  - LIFT procedure for posterior fistula-in-ano. Are outcomes good enough? A 
      systematic review and meta-analysisis of observational studies.
PG  - 183-189
LID - S0009-739X(20)30277-3 [pii]
LID - 10.1016/j.ciresp.2020.08.009 [doi]
AB  - INTRODUCTION: Efficacy of the ligation of intersphincteric fistula tract (LIFT) 
      procedure for posterior fistula-in-ano remains under debate. However, there is 
      scarcity of quality evidence analysing this issue. Thus, the aim of this study is 
      to evaluate outcomes of LIFT surgery in patients with posterior anal fistula. 
      MATERIAL AND METHODS: Systematic review and meta-analysis to evaluate efficacy of 
      LIFT procedure for posterior anal fistula. MEDLINE (PubMed), EMBASE, Scopus, Web 
      of Science, Cochrane Library and Google Scholar data sources were searched for 
      key-words (MeSH terms): "LIFT" OR "Ligation of the intersphincteric fistula 
      tract" AND "posterior anal fistula" OR "posterior fistula-in-ano". Original, 
      observational and experimental, non-language restriction studies published from 
      January 2000 to March 2020 and reporting outcomes on LIFT procedure for posterior 
      anal fistula were reviewed. Quality and potential biases were assessed using 
      Newcastle-Ottawa scale, following AHRQ recommendations. Additional sensitivity 
      analysis and publication bias evaluation (Beg and Egger's tets) were performed. 
      RESULTS: No significant differences were found in recurrence rate among patients 
      undergoing LIFT procedure for posterior fistula-in-ano in contrast to other 
      locations (OR 1.36 [IC 95% 0.60-3.07]; p=.46). I(2) test value was 77%, 
      expressing a fair heterogeneity among included studies. The weighed median for 
      overall recurrence was 37.8% (RI 18.3-47.7%); with a weighed median of 47.1% (RI 
      30.7 - 63.7%) and 36.3% (RI 15.8-51.3%) (p=.436) respectively for recurrence 
      after LIFT for posterior fistula and fistula in other locations. There was not 
      clear evidence about the sample size ("n") of included studies nor the 
      disparities in quality assessment of those, could justify the observed 
      heterogeneity. No significant publication bias was found. CONCLUSION: This 
      systematic review and meta-analysis suggests that there are no clear data in the 
      literature for not performing the LIFT procedure in posteriorly located fistulas.
CI  - Copyright (c) 2020 AEC. Publicado por Elsevier Espana, S.L.U. All rights reserved.
FAU - Placer Galan, Carlos
AU  - Placer Galan C
AD  - Seccion de Cirugia Colo-rectal, Servicio de Cirugia General y Digestiva, Hospital 
      Universitario Donostia, Biodonostia, San Sebastian, Espana. Electronic address: 
      carlos943313762@gmail.com.
FAU - Aguirre, Ignacio
AU  - Aguirre I
AD  - Seccion de Cirugia Colo-rectal, Servicio de Cirugia General y Digestiva, Hospital 
      Universitario Donostia, Biodonostia, San Sebastian, Espana.
FAU - Pastor, Tania
AU  - Pastor T
AD  - Seccion de Cirugia Colo-rectal, Servicio de Cirugia General y Digestiva, Hospital 
      Universitario Donostia, Biodonostia, San Sebastian, Espana.
FAU - Etxart, Ane
AU  - Etxart A
AD  - Seccion de Cirugia Colo-rectal, Servicio de Cirugia General y Digestiva, Hospital 
      Universitario Donostia, Biodonostia, San Sebastian, Espana.
FAU - Enriquez Navascues, Jose Maria
AU  - Enriquez Navascues JM
AD  - Seccion de Cirugia Colo-rectal, Servicio de Cirugia General y Digestiva, Hospital 
      Universitario Donostia, Biodonostia, San Sebastian, Espana.
LA  - eng
LA  - spa
PT  - Journal Article
PT  - Review
TT  - Procedimiento LIFT en fistulas anales de localizacion posterior.  inverted question markSon buenos los 
      resultados? Revision sistematica y metaanalisis de estudios observacionales.
DEP - 20201207
PL  - Spain
TA  - Cir Esp (Engl Ed)
JT  - Cirugia espanola
JID - 101771152
SB  - IM
OTO - NOTNLM
OT  - Fistula recurrence
OT  - Fistula anal posterior
OT  - LIFT
OT  - Ligadura interesfinteriana del tracto fistuloso
OT  - Ligation of the intersphincteric fistula tract
OT  - Meta analysis
OT  - Metaanalisis
OT  - Posterior fistula-in-ano
OT  - Recurrencia
EDAT- 2020/12/12 06:00
MHDA- 2020/12/12 06:01
CRDT- 2020/12/11 05:42
PHST- 2020/05/30 00:00 [received]
PHST- 2020/06/28 00:00 [revised]
PHST- 2020/08/23 00:00 [accepted]
PHST- 2020/12/12 06:00 [pubmed]
PHST- 2020/12/12 06:01 [medline]
PHST- 2020/12/11 05:42 [entrez]
AID - S0009-739X(20)30277-3 [pii]
AID - 10.1016/j.ciresp.2020.08.009 [doi]
PST - ppublish
SO  - Cir Esp (Engl Ed). 2021 Mar;99(3):183-189. doi: 10.1016/j.ciresp.2020.08.009. 
      Epub 2020 Dec 7.