PMID- 33303765
OWN - NLM
STAT- MEDLINE
DCOM- 20210507
LR  - 20210507
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Dec 10
TI  - Systematic review and meta-analysis of the associations of vegan and vegetarian 
      diets with inflammatory biomarkers.
PG  - 21736
LID - 10.1038/s41598-020-78426-8 [doi]
LID - 21736
AB  - Plant-based diets like vegetarian or vegan diets might influence circulating 
      levels of inflammatory biomarkers, thereby reducing the risk of chronic diseases. 
      This systematic review and meta-analysis aimed to investigate the associations of 
      veganism and vegetarianism with circulating inflammatory biomarkers in comparison 
      to omnivores. Literature search was conducted in Pubmed and EMBASE until April 
      2020 and mean differences of biomarkers were assessed for: C-reactive protein 
      (CRP), interleukin-6 (IL-6), interleukin-18 (IL-18), interleukin-1 receptor 
      antagonist (IL-1 RA), tumor necrosis factor-alpha (TNF-a), E-selectin, 
      intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 
      (MCP-1), adiponectin, omentin-1 and resistin. Of initially identified 1073 
      publications, 21 cross-sectional studies met the inclusion criteria and were 
      included in the systematic review and meta-analysis. Vegan diet was associated 
      with lower levels of CRP compared to omnivores [mean difference - 0.54 mg/l, 
      95%-CI: - 0.79 to - 0.28, p < 0.0001]. This association was less pronounced in 
      vegetarians [mean difference - 0.25 mg/l, 95%-CI: - 0.49 to 0.00, p = 0.05]. In 
      patients with impaired kidney function, the association between vegetarian 
      nutrition and CRP was much stronger with - 3.91 mg/l (95%-CI: - 5.23 to - 2.60; 
      p < 0.0001). No substantial effects were observed for all other inflammatory 
      biomarkers. Despite strong associations between CRP and a vegan or vegetarian 
      diet were seen, further research is needed, as most inflammatory biomarkers were 
      investigated only in single studies so far.
FAU - Menzel, Juliane
AU  - Menzel J
AD  - Department of Food Safety, German Federal Institute for Risk Assessment, 
      Max-Dohrn-Str. 8-10, 10589, Berlin, Germany. Juliane.Menzel@bfr.bund.de.
FAU - Jabakhanji, Afraa
AU  - Jabakhanji A
AD  - Department of Food Safety, German Federal Institute for Risk Assessment, 
      Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.
FAU - Biemann, Ronald
AU  - Biemann R
AD  - Institute for Clinical Chemistry and Pathobiochemistry, Otto-Von-Guericke 
      University Magdeburg, Magdeburg, Germany.
AD  - Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, 
      University of Leipzig, Leipzig, Germany.
FAU - Mai, Knut
AU  - Mai K
AD  - Department of Endocrinology and Metabolism, Charite - Universitatsmedizin Berlin, 
      Berlin, Germany.
AD  - Center for Cardiovascular Research (CCR), Charite - Universitatsmedizin Berlin, 
      Berlin, Germany.
AD  - German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, 
      Germany.
FAU - Abraham, Klaus
AU  - Abraham K
AD  - Department of Food Safety, German Federal Institute for Risk Assessment, 
      Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.
FAU - Weikert, Cornelia
AU  - Weikert C
AD  - Department of Food Safety, German Federal Institute for Risk Assessment, 
      Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20201210
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-6)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Biomarkers/blood
MH  - *C-Reactive Protein
MH  - Chronic Disease/*prevention & control
MH  - *Diet, Vegan
MH  - *Diet, Vegetarian
MH  - Inflammation/*diagnosis/*prevention & control
MH  - Inflammation Mediators/*blood
MH  - Interleukin 1 Receptor Antagonist Protein/blood
MH  - Interleukin-18/*blood
MH  - Interleukin-6/*blood
PMC - PMC7730154
COIS- The authors declare no competing interests.
EDAT- 2020/12/12 06:00
MHDA- 2021/05/08 06:00
PMCR- 2020/12/10
CRDT- 2020/12/11 05:52
PHST- 2020/07/17 00:00 [received]
PHST- 2020/11/17 00:00 [accepted]
PHST- 2020/12/11 05:52 [entrez]
PHST- 2020/12/12 06:00 [pubmed]
PHST- 2021/05/08 06:00 [medline]
PHST- 2020/12/10 00:00 [pmc-release]
AID - 10.1038/s41598-020-78426-8 [pii]
AID - 78426 [pii]
AID - 10.1038/s41598-020-78426-8 [doi]
PST - epublish
SO  - Sci Rep. 2020 Dec 10;10(1):21736. doi: 10.1038/s41598-020-78426-8.