PMID- 33304139
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201212
IS  - 1319-562X (Print)
IS  - 2213-7106 (Electronic)
IS  - 2213-7106 (Linking)
VI  - 27
IP  - 12
DP  - 2020 Dec
TI  - Down-regulation of hepatic G-6-Pase expression in hyperglycemic rats: 
      Intervention with biogenic gold nanoconjugate.
PG  - 3334-3341
LID - 10.1016/j.sjbs.2020.09.026 [doi]
AB  - Chronic diabetes extensively complicates the glucose metabolism to onset and 
      progress the complication. Concurrently, several contemporary medicines, 
      especially organo-metallic formulations, are emerging to treat hyperglycemia. The 
      current study aims to emphasize the gold nanoparticles (GNPs) potential for 
      glucose metabolism regulation in Streptozotocin (STZ) induced diabetes. 
      Quantitative real-time polymerase chain reaction (RT-PCR) was carried out to 
      detect the mRNA expression of Glucose transporters 2 (GLUT2), Glucokinase (GK) 
      and Glucose 6 Phosphatase (G-6-Pase). The study shows remarkable results such as 
      the prognostic effect of GNPs in reinforcing the repression of enzyme complex 
      G-6-Pase about 13.3-fold when compared to diabetes control. Also, molecular 
      docking studies showed significant inhibition of G-6-Pase by the terpenoid 
      ligands with alpha and beta amyrin from leaf extract of Couroupita guianensis. 
      Thus the study explored the novel mechanism of G-6-Pase downregulated by GNPs 
      intervention that majorly contributes to the regulation of circulatory glucose 
      homeostasis during diabetes.
CI  - (c) 2020 The Author(s).
FAU - Manimegalai, Sengani
AU  - Manimegalai S
AD  - Department of Bio-Medical Sciences, School of BioSciences and Technology, Vellore 
      Institute of Technology (VIT), Vellore 632 014, Tamil Nadu, India.
FAU - Mahboob, Shahid
AU  - Mahboob S
AD  - Department of Zoology, College of Science, King Saud University, Riyadh 11451, 
      Saudi Arabia.
FAU - Al-Ghanim, Khalid A
AU  - Al-Ghanim KA
AD  - Department of Zoology, College of Science, King Saud University, Riyadh 11451, 
      Saudi Arabia.
FAU - Al-Misned, Fahad
AU  - Al-Misned F
AD  - Department of Zoology, College of Science, King Saud University, Riyadh 11451, 
      Saudi Arabia.
FAU - Govindarajan, Marimuthu
AU  - Govindarajan M
AD  - Unit of Vector Control, Phytochemistry and Nanotechnology, Department of Zoology, 
      Annamalai University, Annamalainagar 608 002, Tamil Nadu, India.
AD  - Department of Zoology, Government College for Women (Autonomous), Kumbakonam 612 
      001, Tamil Nadu, India.
FAU - Anbarasu, Krishnan
AU  - Anbarasu K
AD  - Department of Bioinformatics, School of Life Sciences, Vels Institute of Science, 
      Technology & Advanced Studies, Pallavaram, Chennai 600 117, Tamil Nadu, India.
FAU - Devi Rajeswari, Vijayarangan
AU  - Devi Rajeswari V
AD  - Department of Bio-Medical Sciences, School of BioSciences and Technology, Vellore 
      Institute of Technology (VIT), Vellore 632 014, Tamil Nadu, India.
LA  - eng
PT  - Journal Article
DEP - 20200922
PL  - Saudi Arabia
TA  - Saudi J Biol Sci
JT  - Saudi journal of biological sciences
JID - 101543796
PMC - PMC7715047
OTO - NOTNLM
OT  - Couroupita guianensis
OT  - Diabetes
OT  - Glucose 6 phosphatase
OT  - Gold nanoparticles
OT  - Quantitative RT-PCR
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2020/12/12 06:00
MHDA- 2020/12/12 06:01
PMCR- 2020/09/22
CRDT- 2020/12/11 06:01
PHST- 2020/07/22 00:00 [received]
PHST- 2020/08/30 00:00 [revised]
PHST- 2020/09/13 00:00 [accepted]
PHST- 2020/12/11 06:01 [entrez]
PHST- 2020/12/12 06:00 [pubmed]
PHST- 2020/12/12 06:01 [medline]
PHST- 2020/09/22 00:00 [pmc-release]
AID - S1319-562X(20)30432-0 [pii]
AID - 10.1016/j.sjbs.2020.09.026 [doi]
PST - ppublish
SO  - Saudi J Biol Sci. 2020 Dec;27(12):3334-3341. doi: 10.1016/j.sjbs.2020.09.026. 
      Epub 2020 Sep 22.