PMID- 33304208
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201212
IS  - 1592-9558 (Print)
IS  - 1592-9566 (Electronic)
IS  - 1592-9558 (Linking)
VI  - 33
IP  - 3
DP  - 2020 Sep 30
TI  - A Prospective, Multicenter, Pilot Trial Of A Novel Homologous Skin Construct On 
      Deep Partial-Thickness And Full-Thickness Burns.
PG  - 191-197
AB  - Split-thickness skin grafting (STSG) is the standard of care for treating deep 
      burns. They often contract, have unpredictable cosmetic outcomes, lack dermal 
      appendages, and result in painful, conspicuous donor sites. An autologous 
      homologous skin construct (AHSC) has been shown to produce full-thickness skin 
      architecture. This study examined the safety profile, engraftment, and quality of 
      healing of a pilot group of AHSC-treated burn wounds. Following IRB approval and 
      informed consent, patients with deep-partial/full-thickness burns requiring 
      grafting underwent side-by-side treatment with AHSC and STSG. A 2 cm2 
      fullthickness harvest was processed into AHSC at an FDA-registered facility, 
      returned within 48 hours, and applied to a 4 cm2 area alongside a STSG. AHSC 
      donor site was closed primarily. Wounds were evaluated for healing with digital 
      photography and investigator assessments for 90 days. All adverse events (AEs) 
      were recorded. Eight patients with average 13.3% TBSA [range 2-58%] burn wounds 
      were treated: 5 Caucasian and 3 African American with an average body mass index 
      (BMI) of 26.8. Injury was due to predominantly flame burn, with additional injury 
      from grease, scald, contact, friction and flash. Mean time between injury and 
      AHSC treatment was 11 days [range 5-35 days]. All patients had adequate 
      engraftment and complete epithelialization by the end of the study. Patients 
      required one application of AHSC and no other additional surgical procedures at 
      the application sites. The most common AEs for STSG-treated wounds included 
      hypertrophic scarring and pruritus. One non-infected AHSC harvest site 
      experienced a dehiscence. There were no other AEs related to AHSC treatment. AHSC 
      treatment is feasible in deep partial and fullthickness burn wounds warranting 
      additional investigation.
CI  - Copyright (c) 2020 Euro-Mediterranean Council for Burns and Fire Disasters.
FAU - Feldman, M J
AU  - Feldman MJ
AD  - Division of Plastic and Reconstructive Surgery, Virginia Commonwealth University, 
      Richmond, Virginia, USA.
FAU - McLawhorn, M M
AU  - McLawhorn MM
AD  - Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research 
      Institute, Washington DC, USA.
FAU - Han, J
AU  - Han J
AD  - Division of Plastic and Reconstructive Surgery, Virginia Commonwealth University, 
      Richmond, Virginia, USA.
FAU - Marcu, A C
AU  - Marcu AC
AD  - Division of Plastic and Reconstructive Surgery, Virginia Commonwealth University, 
      Richmond, Virginia, USA.
FAU - Burkey, S E
AU  - Burkey SE
AD  - Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research 
      Institute, Washington DC, USA.
FAU - Travis, T E
AU  - Travis TE
AD  - Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research 
      Institute, Washington DC, USA.
AD  - The Burn Center, MedStar Washington Hospital Center, Washington, DC, USA.
AD  - Department of Surgery, Georgetown School of Medicine, Washington DC, USA.
FAU - Johnson, L S
AU  - Johnson LS
AD  - Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research 
      Institute, Washington DC, USA.
AD  - The Burn Center, MedStar Washington Hospital Center, Washington, DC, USA.
AD  - Department of Surgery, Georgetown School of Medicine, Washington DC, USA.
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Ann Burns Fire Disasters
JT  - Annals of burns and fire disasters
JID - 101251186
PMC - PMC7680199
OTO - NOTNLM
OT  - autologous homologous skin construct
OT  - deep partial-thickness burns
OT  - full-thickness burns
EDAT- 2020/12/12 06:00
MHDA- 2020/12/12 06:01
PMCR- 2020/09/30
CRDT- 2020/12/11 06:01
PHST- 2020/05/25 00:00 [received]
PHST- 2020/08/26 00:00 [accepted]
PHST- 2020/12/11 06:01 [entrez]
PHST- 2020/12/12 06:00 [pubmed]
PHST- 2020/12/12 06:01 [medline]
PHST- 2020/09/30 00:00 [pmc-release]
PST - ppublish
SO  - Ann Burns Fire Disasters. 2020 Sep 30;33(3):191-197.