PMID- 33305819
OWN - NLM
STAT- MEDLINE
DCOM- 20211129
LR  - 20240102
IS  - 1699-5848 (Electronic)
IS  - 0213-3911 (Linking)
VI  - 36
IP  - 4
DP  - 2021 Apr
TI  - Pancreatic neuroendocrine neoplasms: Clinicopathological features and 
      pathological staging.
PG  - 367-382
LID - 10.14670/HH-18-288 [doi]
AB  - The nomenclature and classification of pancreatic neuroendocrine neoplasms has 
      evolved in the last 15 years based on the advances in knowledge of the genomics, 
      clinical behaviour and response to therapies. The current 2019 World Health 
      Organization classification of pancreatic neuroendocrine neoplasms categorises 
      them into three groups; pancreatic neuroendocrine tumours (PanNETs)(grade 1 grade 
      2, grade 3), pancreatic neuroendocrine carcinomas and mixed 
      neuroendocrine-non-neuroendocrine neoplasms (MiNENs) based on the mitotic rate, 
      Ki-67 index, morphological differentiation and/or co-existing tissue subtype. 
      PanNETs are also classified into non-functional NET, insulinoma, gastrinoma, 
      VIPoma, glucagonoma, somatostatinoma, ACTH-producing NET and serotonin producing 
      NET based on hormone production and clinical manifestations. A portion of the 
      cases were associated with genetic syndromes such as multiple neuroendocrine 
      neoplasia 1 (MEN 1), neurofibromatosis and Von Hippel-Lindau syndrome. In view of 
      the distinctive pathology and clinical behaviour of PanNENs, the current 8th 
      AJCC/UICC staging system has separated prognostic staging grouping for PanNETs 
      from the pancreatic neuroendocrine carcinomas or MiNENs. Pancreatic 
      neuroendocrine carcinomas and MiNENs are staged according to the prognostic stage 
      grouping for exocrine pancreatic carcinoma. The new stage grouping of PanNETs was 
      validated to have survival curves separated between different prognostic groups. 
      This refined histological and staging would lead to appropriate selections of 
      treatment strategies for the patients with pancreatic neuroendocrine neoplasms.
FAU - Lam, Alfred King-Yin
AU  - Lam AK
AD  - School of Medicine, Griffith University, Gold Coast, QLD, Australia. 
      a.lam@griffith.edu.au.
FAU - Ishida, Hirotaka
AU  - Ishida H
AD  - School of Medicine, Griffith University, Gold Coast, QLD, Australia.
LA  - eng
GR  - -/-/
PT  - Journal Article
PT  - Review
DEP - 20201211
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
SB  - IM
MH  - Humans
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - *Neuroendocrine Tumors/classification/diagnosis/pathology
MH  - *Pancreatic Neoplasms/classification/diagnosis/pathology
MH  - Prognosis
EDAT- 2020/12/12 06:00
MHDA- 2021/11/30 06:00
CRDT- 2020/12/11 08:39
PHST- 2020/12/12 06:00 [pubmed]
PHST- 2021/11/30 06:00 [medline]
PHST- 2020/12/11 08:39 [entrez]
AID - HH-18-288 [pii]
AID - 10.14670/HH-18-288 [doi]
PST - ppublish
SO  - Histol Histopathol. 2021 Apr;36(4):367-382. doi: 10.14670/HH-18-288. Epub 2020 
      Dec 11.