PMID- 33306775
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210116
IS  - 1415-4757 (Print)
IS  - 1678-4685 (Electronic)
IS  - 1415-4757 (Linking)
VI  - 43
IP  - 4
DP  - 2020
TI  - Extensive genomic reshuffling involved in the karyotype evolution of genus 
      Cerradomys (Rodentia: Sigmodontinae: Oryzomyini).
PG  - e20200149
LID - S1415-47572020000600207 [pii]
LID - 10.1590/1678-4685-GMB-2020-0149 [doi]
LID - e20200149
AB  - Rodents of the genus Cerradomys belong to the tribe Oryzomyini and present high 
      chromosome variability with diploid numbers ranging from 2n=46 to 60. Classical 
      cytogenetics and fluorescence in situ hybridization (FISH) with telomeric and 
      whole chromosome-specific probes of another Oryzomyini, Oligoryzomys moojeni 
      (OMO), were used to assess the karyotype evolution of the genus. Results were 
      integrated into a molecular phylogeny to infer the hypothetical direction of 
      chromosome changes. The telomeric FISH showed signals in telomeres in species 
      that diverged early in the phylogeny, plus interstitial telomeric signals (ITS) 
      in some species from the most derived clades (C. langguthi, C. vivoi, C. goytaca, 
      and C. subflavus). Chromosome painting revealed homology from 23 segments of C. 
      maracajuensis and C. marinhus to 32 of C. vivoi. Extensive chromosome 
      reorganization was responsible for karyotypic differences in closely related 
      species. Major drivers for genomic reshuffling were in tandem and centric fusion, 
      fission, paracentric and pericentric inversions or centromere repositioning. 
      Chromosome evolution was associated with an increase and decrease in diploid 
      number in different lineages and ITS indicate remnants of ancient telomeres. 
      Cytogenetics results corroborates that C. goytaca is not a junior synonym of C. 
      subflavus since the karyotypic differences found may lead to reproductive 
      isolation.
FAU - Di-Nizo, Camilla Bruno
AU  - Di-Nizo CB
AUID- ORCID: 0000-0002-6995-5994
AD  - Instituto Butantan, Laboratorio de Ecologia e Evolucao, Sao Paulo, SP, Brazil.
FAU - Ferguson-Smith, Malcolm Andrew
AU  - Ferguson-Smith MA
AD  - Cambridge Resource Centre for Comparative Genomics, Department of Veterinary 
      Medicine, University of Cambridge, Cambridge, United Kingdom.
FAU - Silva, Maria Jose de J
AU  - Silva MJJ
AD  - Instituto Butantan, Laboratorio de Ecologia e Evolucao, Sao Paulo, SP, Brazil.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20201113
PL  - Brazil
TA  - Genet Mol Biol
JT  - Genetics and molecular biology
JID - 100883590
PMC - PMC7783725
EDAT- 2020/12/12 06:00
MHDA- 2020/12/12 06:01
PMCR- 2020/11/13
CRDT- 2020/12/11 17:09
PHST- 2020/05/13 00:00 [received]
PHST- 2020/09/07 00:00 [accepted]
PHST- 2020/12/11 17:09 [entrez]
PHST- 2020/12/12 06:00 [pubmed]
PHST- 2020/12/12 06:01 [medline]
PHST- 2020/11/13 00:00 [pmc-release]
AID - S1415-47572020000600207 [pii]
AID - 1678-4685-GMB-2020-0149 [pii]
AID - 10.1590/1678-4685-GMB-2020-0149 [doi]
PST - epublish
SO  - Genet Mol Biol. 2020 Nov 13;43(4):e20200149. doi: 
      10.1590/1678-4685-GMB-2020-0149. eCollection 2020.