PMID- 33307000
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 224
DP  - 2021 Apr
TI  - Determinants of Optical Coherence Tomography Parameters in a Population-based 
      Study.
PG  - 163-171
LID - S0002-9394(20)30649-8 [pii]
LID - 10.1016/j.ajo.2020.11.015 [doi]
AB  - PURPOSE: To study the effects of age, sex, intraocular pressure (IOP), corneal 
      thickness, axial length (AXL), disc area, and the signal strength of the scan on 
      optical coherence tomography (OCT) parameters of normal subjects in the L V 
      Prasad Eye Institute-Glaucoma Epidemiological and Molecular Genetic Study 
      (LVPEI-GLEAMS), a population-based study. DESIGN: Cross-sectional study. METHODS: 
      A total of 1,100 eyes (1,100 subjects) of normal adults aged between 40 and 80 
      years from LVPEI-GLEAMS underwent macular and optic nerve head imaging with 
      spectral-domain OCT (SDOCT). Effect of age, sex, IOP, central corneal thickness 
      (CCT) and AXL, disc area, and signal strength of the OCT scan on retinal nerve 
      fiber layer (RNFL) thickness, rim area, and ganglion cell-inner plexiform layer 
      (GC-IPL) thickness measurements were evaluated using univariate and multivariate 
      regression models. RESULTS: Mean rim area, RNFL, and GC-IPL thickness were 
      1.31 mm(2) (standard deviation [SD] = 0.22), 93.7 mum (SD = 9.3) and 79.6 mum (SD = 
      8.7), respectively. Age had a negative association with RNFL thickness 
      (coefficient: -0.18, P < .001) and GC-IPL thickness (-0.18, P < .001). GC-IPL 
      thickness was significantly less in women than in men (-1.05, P < .001). AXL had 
      a negative association with rim area (-0.05, P < .001). Disc area was positively 
      associated with RNFL thickness (4.90, P < .001) and rim area (0.15, P < .001). 
      Signal strength of OCT scan was positively associated with RNFL thickness (1.6, P 
      < .001) and negatively associated with rim area (-0.02, P < .001). CONCLUSION: 
      Age, sex, AXL, disc area, and signal strength of the scan were significantly 
      associated with OCT measurements. These factors may need to be considered while 
      interpreting the OCT parameters in pathologic conditions such as glaucoma.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Ramyashri, S
AU  - Ramyashri S
AD  - VST Centre for Glaucoma, L V Prasad Eye Institute, Hyderabad, India.
FAU - Rao, Harsha L
AU  - Rao HL
AD  - Narayana Nethralaya, Bengaluru, India.
FAU - Jonnadula, Ganesh Babu
AU  - Jonnadula GB
AD  - Head - Image Reading Centre, L.V Prasad Eye Institute, Hyderabad, India.
FAU - Addepalli, Uday K
AU  - Addepalli UK
AD  - VST Centre for Glaucoma, L V Prasad Eye Institute, Hyderabad, India.
FAU - Choudhari, Nikhil
AU  - Choudhari N
AD  - VST Centre for Glaucoma, L V Prasad Eye Institute, Hyderabad, India.
FAU - Senthil, Sirisha
AU  - Senthil S
AD  - VST Centre for Glaucoma, L V Prasad Eye Institute, Hyderabad, India.
FAU - Garudadri, Chandrasekhar
AU  - Garudadri C
AD  - VST Centre for Glaucoma, L V Prasad Eye Institute, Hyderabad, India. Electronic 
      address: gcs@lvpei.org.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201208
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Axial Length, Eye
MH  - Cornea/*anatomy & histology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Intraocular Pressure/*physiology
MH  - Male
MH  - Middle Aged
MH  - *Nerve Fibers
MH  - Optic Disk/*diagnostic imaging
MH  - Retinal Ganglion Cells/*cytology
MH  - Sex Factors
MH  - Tomography, Optical Coherence/*standards
EDAT- 2020/12/12 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/12/11 20:09
PHST- 2020/06/25 00:00 [received]
PHST- 2020/11/23 00:00 [revised]
PHST- 2020/11/25 00:00 [accepted]
PHST- 2020/12/12 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/12/11 20:09 [entrez]
AID - S0002-9394(20)30649-8 [pii]
AID - 10.1016/j.ajo.2020.11.015 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2021 Apr;224:163-171. doi: 10.1016/j.ajo.2020.11.015. Epub 2020 
      Dec 8.