PMID- 33307061
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 513
DP  - 2021 Feb
TI  - Revealing the role of glycerophospholipid metabolism in asthma through plasma 
      lipidomics.
PG  - 34-42
LID - S0009-8981(20)30559-3 [pii]
LID - 10.1016/j.cca.2020.11.026 [doi]
AB  - Lipid mediators play an essential role in the pathogenesis of asthma. Many 
      studies on the differential expression of sphingolipids and fatty acid exist, but 
      relatively few concerned about glycerophospholipid (GP) metabolites in asthma. 
      Here, plasma samples from 20 healthy controls and 24 asthmatic patients were 
      collected and analyzed. High-performance liquid chromatography with quadrupole 
      time-of-flight mass spectrometry (HPLC-QTOF-MS) revealed that 29 GPs were 
      identified and relatively quantified as differential metabolites for 
      discriminating asthma patients and healthy subjects, consisting of six major 
      subclasses of GPs. Moreover, a significant relevance was found between the 
      selected metabolites and diagnostic and prognostic indicators of asthma. 
      Remarkably, in subgroup analyses, plasma phosphatidic acid (PA), 
      phosphatidylglycerol (PG), and phosphatidylethanolamine (PE) levels were higher 
      in patients with eosinophilic asthma than non-eosinophilic asthma. 
      Receiver-operating characteristic curve analysis revealed that the power of 
      plasma PA and PG levels to distinguish between asthmatic patients and healthy 
      subjects was strong (all areas under the curves > 0.9; P < 0.05). Our study 
      characterized circulating GP metabolites in patients with asthma and explored 
      their clinical relevance which may help to develop reliable biomarkers for early 
      and accurate diagnosis based on lipid metabolites and provide novel insight into 
      the role of GPs in asthma.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Wang, Shanshan
AU  - Wang S
AD  - Department of Respiratory and Critical Care Medicine, National Clinical Research 
      Center of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Tang, Kun
AU  - Tang K
AD  - Department of Respiratory and Critical Care Medicine, National Clinical Research 
      Center of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Lu, Yanjiao
AU  - Lu Y
AD  - Department of Respiratory and Critical Care Medicine, National Clinical Research 
      Center of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Tian, Zhen
AU  - Tian Z
AD  - Department of Respiratory and Critical Care Medicine, National Clinical Research 
      Center of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Huang, Zhenli
AU  - Huang Z
AD  - Department of Respiratory and Critical Care Medicine, National Clinical Research 
      Center of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Wang, Meijia
AU  - Wang M
AD  - Department of Respiratory and Critical Care Medicine, National Clinical Research 
      Center of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Zhao, Jianping
AU  - Zhao J
AD  - Department of Respiratory and Critical Care Medicine, National Clinical Research 
      Center of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China. Electronic address: 
      zhaojp88@126.com.
FAU - Xie, Jungang
AU  - Xie J
AD  - Department of Respiratory and Critical Care Medicine, National Clinical Research 
      Center of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China. Electronic address: 
      xiejjgg@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20201209
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Biomarkers)
RN  - 0 (Glycerophospholipids)
SB  - IM
MH  - *Asthma/diagnosis
MH  - Biomarkers/metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Glycerophospholipids
MH  - Humans
MH  - Lipid Metabolism
MH  - *Lipidomics
MH  - Metabolomics
OTO - NOTNLM
OT  - Asthma
OT  - Glycerophospholipid
OT  - HPLC-QTOF-MS
OT  - Lipid profiles
OT  - Lipidomics
OT  - Metabolomics
EDAT- 2020/12/12 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/12/11 20:09
PHST- 2020/06/30 00:00 [received]
PHST- 2020/11/09 00:00 [revised]
PHST- 2020/11/29 00:00 [accepted]
PHST- 2020/12/12 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/12/11 20:09 [entrez]
AID - S0009-8981(20)30559-3 [pii]
AID - 10.1016/j.cca.2020.11.026 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2021 Feb;513:34-42. doi: 10.1016/j.cca.2020.11.026. Epub 2020 Dec 
      9.