PMID- 33307622
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20211125
IS  - 2092-9382 (Electronic)
IS  - 1011-8942 (Print)
IS  - 1011-8942 (Linking)
VI  - 35
IP  - 1
DP  - 2021 Feb
TI  - Clinical Characteristics of Uveitis in Patients with Psoriasis in Korea: A 
      Retrospective Multicenter Case Series.
PG  - 64-72
LID - 10.3341/kjo.2020.0131 [doi]
AB  - PURPOSE: To describe the clinical characteristics and treatment outcomes of 
      uveitis in patients with psoriasis in Korea. METHODS: The medical records of 20 
      patients (27 eyes) with psoriatic uveitis in two tertiary hospitals were 
      retrospectively reviewed. We analyzed data about patient demographics, uveitis 
      types, laterality, onset of disease, human leukocyte antigen (HLA) types, 
      intraocular pressure, visual acuity, comorbidities, and medical treatments and 
      outcomes for uveitis and psoriasis. RESULTS: The cohort comprised 11 males and 
      nine females (age of onset, 50.1 +/- 13.2 years) and the mean follow-up period was 
      3.9 +/- 4.0 years. Types of uveitis included anterior (85%), intermediate (10%), 
      and panuveitis (5%). A total of 13 (65%) cases presented with unilateral 
      involvement and 12 out of 18 patients (66.7%) were positive for HLA-B27. The 
      average intraocular pressure of affected eyes was 11.6 +/- 3.6 at the first visit 
      and 13.8 +/- 3.6 mmHg at the final visit. The average logarithm of the minimum 
      angle of resolution visual acuity of affected eyes at the initial examination was 
      0.16 +/- 0.52 and 0.27 +/- 0.71 at the last examination. Most common comorbidity (13 
      patients, 65%) was psoriatic arthritis (PsA). All cases underwent topical 
      corticosteroid treatment; however, 11 (55%) required systemic corticosteroid and 
      immunosuppressants for the treatment of uveitis. Notable deterioration in visual 
      outcome was found in two cases (10%) due to severe intraocular inflammation and 
      its complications (uveitic glaucoma and bullous keratopathy). Recurrent uveitis 
      was observed in 57.9% of patients. Patients with PsA tended to have higher 
      positive rate of HLA-B27 (83.3%). However, there was no significant correlation 
      between visual prognosis and location of psoriatic uveitis, presence of PsA, and 
      HLA-B27 positivity. CONCLUSIONS: Psoriatic uveitis in Koreans usually presents 
      with anterior uveitis with unilateral involvement. PsA was the most common 
      comorbidity. In majority of patients, visual outcomes are satisfactory with 
      appropriate topical or systemic immunosuppressive treatment.
FAU - Lee, Yunjin
AU  - Lee Y
AD  - Department of Ophthalmology, Seoul National University Hospital, Seoul National 
      University College of Medicine, Seoul Korea.
FAU - Oh, Baek-Lok
AU  - Oh BL
AD  - Department of Ophthalmology, Seoul National University Hospital, Seoul National 
      University College of Medicine, Seoul Korea.
FAU - Yu, Hyeong Gon
AU  - Yu HG
AD  - Department of Ophthalmology, Seoul National University Hospital, Seoul National 
      University College of Medicine, Seoul Korea.
FAU - Youn, Sang Woong
AU  - Youn SW
AD  - Department of Dermatology, Seoul National University Bundang Hospital, Seoul 
      National University College of Medicine, Seongnam, Korea.
FAU - Woo, Se Joon
AU  - Woo SJ
AD  - Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul 
      National University College of Medicine, Seongnam, Korea.
LA  - eng
GR  - 2020R1F1A1072795/National Research Foundation of Korea/
GR  - 2018M3A9B5021319/National Research Foundation of Korea/
GR  - Ministry of Science and ICT/
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20201211
PL  - Korea (South)
TA  - Korean J Ophthalmol
JT  - Korean journal of ophthalmology : KJO
JID - 8804513
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Psoriasis/complications/diagnosis/epidemiology
MH  - Republic of Korea/epidemiology
MH  - Retrospective Studies
MH  - *Uveitis/diagnosis/epidemiology
MH  - *Uveitis, Anterior
PMC - PMC7904410
OTO - NOTNLM
OT  - HLA-B27 antigen
OT  - Psoriasis
OT  - Psoriatic arthritis
OT  - Psoriatic uveitis
OT  - Uveitis
COIS- Conflict of Interest No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2020/12/15 06:00
MHDA- 2021/11/26 06:00
PMCR- 2021/02/01
CRDT- 2020/12/14 08:11
PHST- 2020/10/14 00:00 [received]
PHST- 2020/11/25 00:00 [accepted]
PHST- 2020/12/15 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2020/12/14 08:11 [entrez]
PHST- 2021/02/01 00:00 [pmc-release]
AID - kjo.2020.0131 [pii]
AID - kjo-2020-0131 [pii]
AID - 10.3341/kjo.2020.0131 [doi]
PST - ppublish
SO  - Korean J Ophthalmol. 2021 Feb;35(1):64-72. doi: 10.3341/kjo.2020.0131. Epub 2020 
      Dec 11.