PMID- 33307763
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 1549-7852 (Electronic)
IS  - 1040-8398 (Linking)
VI  - 62
IP  - 10
DP  - 2022
TI  - Perspectives on signaling for biological- and processed food-related advanced 
      glycation end-products and its role in cancer progression.
PG  - 2655-2672
LID - 10.1080/10408398.2020.1856771 [doi]
AB  - Receptor for advanced glycation end-products (RAGE) is a multifunctional receptor 
      binds a broad spectrum of ligands and mediates responses to cell damage and 
      stress conditions. It also activates programs leading to acute and chronic 
      inflammation and implicated in several pathological diseases, including cancer. 
      In this review, we presented the non-enzymatic reaction of reducing sugar with 
      the amino groups of proteins, lipids, and nucleic acids. This reaction initiates 
      a complex series of rearrangements and dehydrations, and then produces a class of 
      irreversibly cross-linked heterogeneous fluorescent moieties, termed advanced 
      glycation end products (AGEs). There is a growing body of evidence that 
      interaction of processes food-related AGEs with a cell surface receptor RAGE 
      brings out the generation of oxidative stress and subsequently evokes 
      proliferative, angiogenic and inflammatory reactions, thereby being involved in 
      the development and progression of various types of cancers. This review is an 
      insightful assessment of molecular mechanisms through which RAGE signaling 
      contributes to the enhancement and survival of the tumorigenic cell. Here we 
      summarize the procurement of individual ligands of RAGE like amphoterin, 
      calcium-binding proteins, and resultant mediation of RAGE signaling pathway, 
      which partially can elucidate the elevated risk of several cancers. Besides, we 
      summarize many factors or conditions including APE1 (apurinic/apyrimidinic 
      endonuclease 1), retinol mutations, retinoblastoma (Rb), proteinase 3 (PR3) 
      hypoxia and so on through which RAGE signaling presents an establishment of 
      cancerous environment. Additionally, we also reviewed some recent findings that 
      give shreds of evidence for presenting the role of RAGE and its ligands in the 
      advanced stage of cancers.
FAU - Eva, Taslima Akter
AU  - Eva TA
AD  - Department of Pharmacy, Faculty of Biological Science, University of Chittagong, 
      Chittagong, Bangladesh.
FAU - Barua, Nizum
AU  - Barua N
AD  - Department of Pharmacy, Faculty of Biological Science, University of Chittagong, 
      Chittagong, Bangladesh.
FAU - Chowdhury, Md Mustafiz
AU  - Chowdhury MM
AD  - Department of Pharmacy, Faculty of Biological Science, University of Chittagong, 
      Chittagong, Bangladesh.
FAU - Yeasmin, Sharfin
AU  - Yeasmin S
AD  - Department of Pharmacy, Faculty of Biological Science, University of Chittagong, 
      Chittagong, Bangladesh.
FAU - Rakib, Ahmed
AU  - Rakib A
AUID- ORCID: 0000-0003-3335-0368
AD  - Department of Pharmacy, Faculty of Biological Science, University of Chittagong, 
      Chittagong, Bangladesh.
FAU - Islam, Mohammad Rashedul
AU  - Islam MR
AUID- ORCID: 0000-0002-7632-5157
AD  - Department of Pharmacy, Faculty of Biological Science, University of Chittagong, 
      Chittagong, Bangladesh.
FAU - Emran, Talha Bin
AU  - Emran TB
AUID- ORCID: 0000-0003-3188-2272
AD  - Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, Bangladesh.
FAU - Simal-Gandara, Jesus
AU  - Simal-Gandara J
AUID- ORCID: 0000-0001-9215-9737
AD  - Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, 
      Faculty of Food Science and Technology, University of Vigo-Ourense Campus, 
      Ourense, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201212
PL  - United States
TA  - Crit Rev Food Sci Nutr
JT  - Critical reviews in food science and nutrition
JID - 8914818
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Receptor for Advanced Glycation End Products)
SB  - IM
MH  - *Glycation End Products, Advanced/metabolism
MH  - Humans
MH  - *Neoplasms/metabolism
MH  - Oxidative Stress
MH  - Receptor for Advanced Glycation End Products/metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - AGEs
OT  - RAGE
OT  - autophagy
OT  - calcium-binding protein
OT  - cancer
OT  - glycation
OT  - processed food
EDAT- 2020/12/15 06:00
MHDA- 2022/04/05 06:00
CRDT- 2020/12/14 09:48
PHST- 2020/12/15 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2020/12/14 09:48 [entrez]
AID - 10.1080/10408398.2020.1856771 [doi]
PST - ppublish
SO  - Crit Rev Food Sci Nutr. 2022;62(10):2655-2672. doi: 
      10.1080/10408398.2020.1856771. Epub 2020 Dec 12.