PMID- 33308332
OWN - NLM
STAT- MEDLINE
DCOM- 20211018
LR  - 20211018
IS  - 0317-1671 (Print)
IS  - 0317-1671 (Linking)
VI  - 48
IP  - 5
DP  - 2021 Sep
TI  - Cortical Excitability in Temporal Lobe Epilepsy with Bilateral Tonic-Clonic 
      Seizures.
PG  - 648-654
LID - 10.1017/cjn.2020.267 [doi]
AB  - OBJECTIVE: We investigated motor cortical excitability (CE) in unilateral 
      temporal lobe epilepsy (TLE) and its relationship to bilateral tonic-clonic 
      seizure (BTCS) using paired-pulse transcranial magnetic stimulation (TMS). 
      METHODS: In this cross-sectional study, we enrolled 46 unilateral TLE patients 
      and 16 age-and sex-matched healthy controls. Resting motor thresholds (RMT); 
      short-interval intracortical inhibition (SICI, GABAA receptor-mediated); 
      facilitation (ICF, glutamatergic-mediated) with interstimulus intervals (ISIs) of 
      2, 5, 10, and 15 ms; and long-interval intracortical inhibition (LICI, GABAB 
      receptor-mediated) with ISIs of 200-400 ms were measured via paired-pulse TMS. 
      Comparisons were made between controls and patients with TLE, and then among the 
      TLE subgroups (no BTCS, infrequent BTCS and frequent BTCS subgroup). RESULTS: 
      Compared with controls, TLE patients had higher RMT, lower SICI and higher LICI 
      in both hemispheres, and higher ICF in the ipsilateral hemisphere. In patients 
      with frequent BTCS, cortical hyperexcitability in the ipsilateral hemisphere was 
      found in a parameter-dependent manner (SICI decreased at a stimulation interval 
      of 5 ms, and ICF increased at a stimulation interval of 15 ms) compared with 
      patients with infrequent or no BTCS. CONCLUSIONS: Our results demonstrate that 
      motor cortical hyper-excitability in the ipsilateral hemisphere underlies the 
      epileptogenic network of patients with active BTCS, which is more extensive than 
      those with infrequent or no BTCS.
FAU - Hu, Lingli
AU  - Hu L
AD  - Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Yin, Houmin
AU  - Yin H
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
FAU - Yang, Linling
AU  - Yang L
AD  - Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Chen, Cong
AU  - Chen C
AD  - Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - He, Chenmin
AU  - He C
AD  - Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Chen, Yi
AU  - Chen Y
AD  - Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Zhu, Junming
AU  - Zhu J
AD  - Epilepsy Center, Department of Neurosurgery, Second Affiliated Hospital, School 
      of Medicine, Zhejiang University, Hangzhou, China.
FAU - Ding, Yao
AU  - Ding Y
AD  - Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Wang, Shuang
AU  - Wang S
AD  - Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Ding, Meiping
AU  - Ding M
AD  - Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Wang, Shan
AU  - Wang S
AD  - Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201214
PL  - England
TA  - Can J Neurol Sci
JT  - The Canadian journal of neurological sciences. Le journal canadien des sciences 
      neurologiques
JID - 0415227
SB  - IM
MH  - *Cortical Excitability
MH  - Cross-Sectional Studies
MH  - *Epilepsy, Temporal Lobe
MH  - Evoked Potentials, Motor
MH  - Humans
MH  - *Motor Cortex
MH  - Neural Inhibition
MH  - Seizures
OTO - NOTNLM
OT  - Bilateral tonic-clonic seizure
OT  - Cortical excitability
OT  - Long-interval intracortical inhibition
OT  - Motor threshold
OT  - Short-interval intracortical inhibition and facilitation
OT  - Temporal lobe epilepsy
EDAT- 2020/12/15 06:00
MHDA- 2021/10/21 06:00
CRDT- 2020/12/14 09:53
PHST- 2020/12/15 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2020/12/14 09:53 [entrez]
AID - S031716712000267X [pii]
AID - 10.1017/cjn.2020.267 [doi]
PST - ppublish
SO  - Can J Neurol Sci. 2021 Sep;48(5):648-654. doi: 10.1017/cjn.2020.267. Epub 2020 
      Dec 14.