PMID- 33309626
OWN - NLM
STAT- MEDLINE
DCOM- 20211018
LR  - 20211018
IS  - 1424-3911 (Electronic)
IS  - 1424-3903 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Jan
TI  - Total gastrectomy for severe proton pump inhibitor-induced hypomagnesemia in a 
      MEN1/Zollinger Ellison syndrome patient.
PG  - 236-239
LID - S1424-3903(20)30862-0 [pii]
LID - 10.1016/j.pan.2020.12.002 [doi]
AB  - We report here the first case of life-threatening hypomagnesemia in a 
      Zollinger-Ellison syndrome patient with multiple endocrine neoplasia type 1 
      (MEN1) syndrome. The severe symptomatic hypomagnesemia proved to be due to proton 
      pump inhibitors (PPIs), but withdrawal of PPIs led to early severe peptic 
      complications despite a substitution by histamine H2-receptor antagonist therapy. 
      Simultaneous management of life-threatening hypomagnesemia, severe gastric acid 
      hypersecretion and MEN1-associated gastrinomas was complex. A total gastrectomy 
      was performed in order to definitely preclude the use of PPIs in this frail 
      patient who was not eligible for curative pancreatoduodenal resection.
CI  - Copyright (c) 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved.
FAU - Perrier, Marine
AU  - Perrier M
AD  - Department of Gastroenterology and Digestive Oncology, Reims University Hospital, 
      Reims, France. Electronic address: mperrier@chu-reims.fr.
FAU - Delemer, Brigitte
AU  - Delemer B
AD  - Department of Endocrinology, Diabetes and Nutrition, Reims University Hospital, 
      Reims, France; Center for Research in Sciences and Technologies of Information 
      and Communication (CReSTIC), University of Reims Champagne Ardennes (URCA), 
      France.
FAU - Deguelte, Sophie
AU  - Deguelte S
AD  - Department of General and Digestive Surgery, Reims University Hospital, Reims, 
      France.
FAU - Legros, Vincent
AU  - Legros V
AD  - Department of Intensive Care Medicine, Reims University Hospital, Reims, France.
FAU - Brixi, Hedia
AU  - Brixi H
AD  - Department of Gastroenterology and Digestive Oncology, Reims University Hospital, 
      Reims, France.
FAU - Kianmanesh, Reza
AU  - Kianmanesh R
AD  - Department of General and Digestive Surgery, Reims University Hospital, Reims, 
      France.
FAU - Cadiot, Guillaume
AU  - Cadiot G
AD  - Department of Gastroenterology and Digestive Oncology, Reims University Hospital, 
      Reims, France.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20201207
PL  - Switzerland
TA  - Pancreatology
JT  - Pancreatology : official journal of the International Association of 
      Pancreatology (IAP) ... [et al.]
JID - 100966936
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Frailty
MH  - Gastrectomy/*methods
MH  - Humans
MH  - Magnesium Deficiency/*chemically induced/*surgery
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/complications/*surgery
MH  - Peptic Ulcer/drug therapy
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Stomach/pathology
MH  - Treatment Outcome
MH  - Zollinger-Ellison Syndrome/complications/*surgery
OTO - NOTNLM
OT  - Gastrinoma
OT  - Hypomagnesemia
OT  - Multiple endocrine neoplasia type 1 syndrome
OT  - Proton pump inhibitor
OT  - Total gastrectomy
OT  - Zollinger-Ellison syndrome
EDAT- 2020/12/15 06:00
MHDA- 2021/10/21 06:00
CRDT- 2020/12/14 10:15
PHST- 2020/05/24 00:00 [received]
PHST- 2020/12/01 00:00 [revised]
PHST- 2020/12/02 00:00 [accepted]
PHST- 2020/12/15 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2020/12/14 10:15 [entrez]
AID - S1424-3903(20)30862-0 [pii]
AID - 10.1016/j.pan.2020.12.002 [doi]
PST - ppublish
SO  - Pancreatology. 2021 Jan;21(1):236-239. doi: 10.1016/j.pan.2020.12.002. Epub 2020 
      Dec 7.