PMID- 33309832
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 594
DP  - 2021 Feb 1
TI  - Delivery of acetaminophen to the central nervous system and the pharmacological 
      effect after intranasal administration with a mucoadhesive agent and absorption 
      enhancer.
PG  - 120046
LID - S0378-5173(20)31031-0 [pii]
LID - 10.1016/j.ijpharm.2020.120046 [doi]
AB  - Acetaminophen, a central antipyretic and analgesic drug, is one of the most 
      commonly used drugs among individuals of all ages throughout the world. This 
      study pharmacokinetically and pharmacodynamically investigated the transport of 
      acetaminophen to the central nervous system and systemic circulation after 
      intranasal (i.n.) administration, and evaluated the potential of a transnasal 
      acetaminophen formulation in comparison to other routes of administration. Direct 
      transport to the brain and the pharmacological effect after the i.n. 
      administration of acetaminophen with polyvinylpyrrolidone (PVP; a mucoadhesive 
      agent) and poly-l-arginine (PLA; an absorption enhancer) were investigated to 
      improve retention of the dosage solution in the olfactory epithelium region and 
      enhance the transfer of acetaminophen to the brain. The transport of 
      acetaminophen to the brain was rapid, and the concentration in the brain, 
      especially the olfactory bulb, was higher after i.n. administration, resulting in 
      a greater antipyretic effect in comparison to other routes of administration. The 
      delivery system using PVP and PLA produced a high and prolonged antipyretic 
      effect by enhancing the transfer of acetaminophen to the brain through 
      suppression of the transfer to systemic circulation. Thus, this transnasal drug 
      delivery system using PVP and PLA may be a promising method for transporting 
      acetaminophen to the brain.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Ogawa, Kaho
AU  - Ogawa K
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, 
      Sakado, Saitama 350-0295, Japan.
FAU - Uchida, Masaki
AU  - Uchida M
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, 
      Sakado, Saitama 350-0295, Japan.
FAU - Yamaki, Tsutomu
AU  - Yamaki T
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, 
      Sakado, Saitama 350-0295, Japan.
FAU - Matsuzaki, Hirokazu
AU  - Matsuzaki H
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, 
      Sakado, Saitama 350-0295, Japan.
FAU - Kimura, Mitsutoshi
AU  - Kimura M
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, 
      Sakado, Saitama 350-0295, Japan.
FAU - Okazaki, Mari
AU  - Okazaki M
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, 
      Sakado, Saitama 350-0295, Japan.
FAU - Uchida, Hiroyuki
AU  - Uchida H
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, 
      Sakado, Saitama 350-0295, Japan.
FAU - Natsume, Hideshi
AU  - Natsume H
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, 
      Sakado, Saitama 350-0295, Japan. Electronic address: natsume@josai.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20201211
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - *Acetaminophen
MH  - Administration, Intranasal
MH  - Brain
MH  - *Central Nervous System
MH  - Drug Delivery Systems
MH  - Humans
OTO - NOTNLM
OT  - Acetaminophen
OT  - Antipyretic effect
OT  - Direct transport to the brain
OT  - Intranasal administration
OT  - Poly-l-arginine (PLA)
OT  - Polyvinylpyrrolidone (PVP)
EDAT- 2020/12/15 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/12/14 10:17
PHST- 2020/09/01 00:00 [received]
PHST- 2020/10/19 00:00 [revised]
PHST- 2020/11/01 00:00 [accepted]
PHST- 2020/12/15 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/12/14 10:17 [entrez]
AID - S0378-5173(20)31031-0 [pii]
AID - 10.1016/j.ijpharm.2020.120046 [doi]
PST - ppublish
SO  - Int J Pharm. 2021 Feb 1;594:120046. doi: 10.1016/j.ijpharm.2020.120046. Epub 2020 
      Dec 11.