PMID- 33309851
OWN - NLM
STAT- MEDLINE
DCOM- 20220304
LR  - 20220304
IS  - 1096-3650 (Electronic)
IS  - 1044-579X (Linking)
VI  - 73
DP  - 2021 Aug
TI  - Nuclear receptors: Lipid and hormone sensors with essential roles in the control 
      of cancer development.
PG  - 58-75
LID - S1044-579X(20)30267-4 [pii]
LID - 10.1016/j.semcancer.2020.12.007 [doi]
AB  - Nuclear receptors (NRs) are a superfamily of ligand-activated transcription 
      factors that act as biological sensors and use a combination of mechanisms to 
      modulate positively and negatively gene expression in a spatial and temporal 
      manner. The highly orchestrated biological actions of several NRs influence the 
      proliferation, differentiation, and apoptosis of many different cell types. 
      Synthetic ligands for several NRs have been the focus of extensive drug discovery 
      efforts for cancer intervention. This review summarizes the roles in tumour 
      growth and metastasis of several relevant NR family members, namely androgen 
      receptor (AR), estrogen receptor (ER), glucocorticoid receptor (GR), thyroid 
      hormone receptor (TR), retinoic acid receptors (RARs), retinoid X receptors 
      (RXRs), peroxisome proliferator-activated receptors (PPARs), and liver X 
      receptors (LXRs). These studies are key to develop improved therapeutic agents 
      based on novel modes of action with reduced side effects and overcoming 
      resistance.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Font-Diaz, Joan
AU  - Font-Diaz J
AD  - Department of Cell Biology, Physiology and Immunology, School of Biology, 
      University of Barcelona, Barcelona, 08028, Spain; Institute of Biomedicine of the 
      University of Barcelona (IBUB), Barcelona, 08028, Spain.
FAU - Jimenez-Panizo, Alba
AU  - Jimenez-Panizo A
AD  - Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, 08028, 
      Spain; Department of Biochemistry and Molecular Biomedicine, School of Biology, 
      University of Barcelona, Barcelona, 08028, Spain.
FAU - Caelles, Carme
AU  - Caelles C
AD  - Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, 08028, 
      Spain; Department of Biochemistry and Physiology, School of Pharmacy and Food 
      Sciences, University of Barcelona, Barcelona, 08028, Spain.
FAU - Vivanco, Maria dM
AU  - Vivanco MD
AD  - CIC bioGUNE, Basque Research Technology Alliance, BRTA, Bizkaia Technology Park, 
      Derio, 48160, Spain.
FAU - Perez, Paloma
AU  - Perez P
AD  - Instituto de Biomedicina de Valencia (IBV)-CSIC, Valencia, 46010, Spain.
FAU - Aranda, Ana
AU  - Aranda A
AD  - Instituto de Investigaciones Biomedicas "Alberto Sols", Consejo Superior de 
      Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, 28029, 
      Spain.
FAU - Estebanez-Perpina, Eva
AU  - Estebanez-Perpina E
AD  - Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, 08028, 
      Spain; Department of Biochemistry and Molecular Biomedicine, School of Biology, 
      University of Barcelona, Barcelona, 08028, Spain.
FAU - Castrillo, Antonio
AU  - Castrillo A
AD  - Instituto de Investigaciones Biomedicas "Alberto Sols", Consejo Superior de 
      Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, 28029, 
      Spain; Unidad de Biomedicina, (Unidad Asociada al CSIC), Instituto de 
      Investigaciones Biomedicas Alberto Sols (CSIC-UAM), Universidad de Las Palmas, 
      Gran Canaria, 35001, Spain.
FAU - Ricote, Mercedes
AU  - Ricote M
AD  - Area of Myocardial Pathophysiology, Centro Nacional de Investigaciones 
      Cardiovasculares (CNIC), Madrid, 28029, Spain.
FAU - Valledor, Annabel F
AU  - Valledor AF
AD  - Department of Cell Biology, Physiology and Immunology, School of Biology, 
      University of Barcelona, Barcelona, 08028, Spain; Institute of Biomedicine of the 
      University of Barcelona (IBUB), Barcelona, 08028, Spain. Electronic address: 
      afernandezvalledor@ub.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201209
PL  - England
TA  - Semin Cancer Biol
JT  - Seminars in cancer biology
JID - 9010218
RN  - 0 (Hormones)
RN  - 0 (Lipids)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
SB  - IM
MH  - Animals
MH  - *Hormones
MH  - Humans
MH  - *Lipids
MH  - *Neoplasms
MH  - *Receptors, Cytoplasmic and Nuclear
OTO - NOTNLM
OT  - Apoptosis
OT  - Cancer
OT  - Metastasis
OT  - Nuclear receptor
OT  - Proliferation
EDAT- 2020/12/15 06:00
MHDA- 2022/03/05 06:00
CRDT- 2020/12/14 10:17
PHST- 2020/09/02 00:00 [received]
PHST- 2020/12/04 00:00 [revised]
PHST- 2020/12/04 00:00 [accepted]
PHST- 2020/12/15 06:00 [pubmed]
PHST- 2022/03/05 06:00 [medline]
PHST- 2020/12/14 10:17 [entrez]
AID - S1044-579X(20)30267-4 [pii]
AID - 10.1016/j.semcancer.2020.12.007 [doi]
PST - ppublish
SO  - Semin Cancer Biol. 2021 Aug;73:58-75. doi: 10.1016/j.semcancer.2020.12.007. Epub 
      2020 Dec 9.