PMID- 33310039 OWN - NLM STAT- MEDLINE DCOM- 20210201 LR - 20210201 IS - 1879-0631 (Electronic) IS - 0024-3205 (Linking) VI - 266 DP - 2021 Feb 1 TI - High-intensity interval training is more effective than continuous training to reduce inflammation markers in female rats with cisplatin nephrotoxicity. PG - 118880 LID - S0024-3205(20)31633-7 [pii] LID - 10.1016/j.lfs.2020.118880 [doi] AB - AIMS: Cisplatin (CP) is an antineoplastic widely used in the treatment of various solid tumors, however, its clinical application is limited by nephrotoxicity. Here, we compared the impact of preconditioning with high-intensity interval training (HIIT) with continuous training of low (LIT) and moderate (MIT) intensity on innate immunity markers in female rats with CP-induced acute kidney injury. MATERIALS AND METHODS: The rats were divided into five groups (n = 7): saline control and sedentary (C + S); CP and sedentary (CP + S); CP and LIT (CP + LIT); CP and MIT (CP + MIT) and CP and HIIT (CP + HIIT). The training intensity was determined by a maximum running test. At the end of training, the rats received a single dose of CP (5 mg/kg), and 7 days later they were euthanized. We evaluated renal function parameters (serum creatinine, glomerular filtration rate and proteinuria), renal structure, macrophage tissue infiltration, immunolocalization of nuclear transcription factor kappa B (NF-kappaB), renal levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), and interleukin 6 (IL-6), and gene expression of monocyte chemoattractant protein-1 (MCP-1), toll-like receptor 4 (TLR4), and NF-kappaB in renal tissue. KEY FINDINGS: Although both MIT and HIIT attenuated the degree of renal injury, only the HIIT prevented changes in renal function. The three training protocols mitigated the increase in expression of all inflammatory markers, however, this effect was more pronounced in HIIT. SIGNIFICANCE: All training protocols promoted renoprotective actions, but HIIT was more effective in mitigating CP-induced acute kidney injury, in part by modulation of important markers of the innate immune response. CI - Copyright (c) 2020 Elsevier Inc. All rights reserved. FAU - Leite, Allyne Baia AU - Leite AB AD - Instituto Multidisciplinar em Saude, Universidade Federal da Bahia, Programa de Pos-Graduacao em Biociencias, Vitoria da Conquista, Bahia 45029-094, Brazil. FAU - Lima, Hernando Nascimento AU - Lima HN AD - Instituto Multidisciplinar em Saude, Universidade Federal da Bahia, Programa de Pos-Graduacao em Biociencias, Vitoria da Conquista, Bahia 45029-094, Brazil. FAU - Flores, Caleb de Oliveira AU - Flores CO AD - Instituto Multidisciplinar em Saude, Universidade Federal da Bahia, Programa de Pos-Graduacao em Biociencias, Vitoria da Conquista, Bahia 45029-094, Brazil. FAU - Oliveira, Caroline Assuncao AU - Oliveira CA AD - Instituto Multidisciplinar em Saude, Universidade Federal da Bahia, Programa de Pos-Graduacao em Biociencias, Vitoria da Conquista, Bahia 45029-094, Brazil. FAU - Cunha, Larissa Esterfanne Cavalcante AU - Cunha LEC AD - Instituto Multidisciplinar em Saude, Universidade Federal da Bahia, Programa de Pos-Graduacao em Biociencias, Vitoria da Conquista, Bahia 45029-094, Brazil. FAU - Neves, Jonas Luz AU - Neves JL AD - Instituto Multidisciplinar em Saude, Universidade Federal da Bahia, Programa de Pos-Graduacao em Biociencias, Vitoria da Conquista, Bahia 45029-094, Brazil. FAU - Correia, Thiago Macedo Lopes AU - Correia TML AD - Instituto Multidisciplinar em Saude, Universidade Federal da Bahia, Programa de Pos-Graduacao em Biociencias, Vitoria da Conquista, Bahia 45029-094, Brazil. FAU - de Melo, Fabricio Freire AU - de Melo FF AD - Instituto Multidisciplinar em Saude, Universidade Federal da Bahia, Programa de Pos-Graduacao em Biociencias, Vitoria da Conquista, Bahia 45029-094, Brazil. FAU - Oliveira, Marcio Vasconcelos AU - Oliveira MV AD - Instituto Multidisciplinar em Saude, Universidade Federal da Bahia, Programa de Pos-Graduacao em Biociencias, Vitoria da Conquista, Bahia 45029-094, Brazil. FAU - de Magalhaes, Amelia Cristina Mendes AU - de Magalhaes ACM AD - Instituto Multidisciplinar em Saude, Universidade Federal da Bahia, Programa de Pos-Graduacao em Biociencias, Vitoria da Conquista, Bahia 45029-094, Brazil. FAU - Soares, Telma de Jesus AU - Soares TJ AD - Instituto Multidisciplinar em Saude, Universidade Federal da Bahia, Programa de Pos-Graduacao em Biociencias, Vitoria da Conquista, Bahia 45029-094, Brazil. FAU - Amaral, Liliany Souza de Brito AU - Amaral LSB AD - Instituto Multidisciplinar em Saude, Universidade Federal da Bahia, Programa de Pos-Graduacao em Biociencias, Vitoria da Conquista, Bahia 45029-094, Brazil. Electronic address: liliany.amaral@gmail.com. LA - eng PT - Journal Article DEP - 20201210 PL - Netherlands TA - Life Sci JT - Life sciences JID - 0375521 RN - 0 (Antineoplastic Agents) RN - 0 (Biomarkers) RN - 0 (Inflammation Mediators) RN - Q20Q21Q62J (Cisplatin) SB - IM MH - Animals MH - Antineoplastic Agents/toxicity MH - Biomarkers/*metabolism MH - Cisplatin/*toxicity MH - Female MH - *High-Intensity Interval Training MH - Inflammation/chemically induced/*drug therapy/metabolism/pathology MH - Inflammation Mediators/*metabolism MH - Kidney Diseases/chemically induced/pathology/*prevention & control MH - *Physical Conditioning, Animal MH - Rats MH - Rats, Wistar OTO - NOTNLM OT - Exercise training OT - High-intensity interval training OT - Inflammation OT - Nephrotoxicity EDAT- 2020/12/15 06:00 MHDA- 2021/02/02 06:00 CRDT- 2020/12/14 10:19 PHST- 2020/09/03 00:00 [received] PHST- 2020/11/27 00:00 [revised] PHST- 2020/12/03 00:00 [accepted] PHST- 2020/12/15 06:00 [pubmed] PHST- 2021/02/02 06:00 [medline] PHST- 2020/12/14 10:19 [entrez] AID - S0024-3205(20)31633-7 [pii] AID - 10.1016/j.lfs.2020.118880 [doi] PST - ppublish SO - Life Sci. 2021 Feb 1;266:118880. doi: 10.1016/j.lfs.2020.118880. Epub 2020 Dec 10.