PMID- 33312062
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220418
IS  - 1452-8258 (Print)
IS  - 1452-8266 (Electronic)
IS  - 1452-8266 (Linking)
VI  - 39
IP  - 4
DP  - 2020 Oct 2
TI  - Assessment of serum tenascin-C and growth differentiation factor-15 among type 2 
      diabetes mellitus patients with and without acute coronary syndrome.
PG  - 460-466
LID - 10.5937/jomb0-24662 [doi]
AB  - BACKGROUND: High prevalence of type 2 diabetes mellitus (T2DM) is associated with 
      a higher prevalence of acute coronary syndrome (ACS). Inflammation is one of the 
      important contributors to the pathogenesis and complications of coronary 
      atherosclerotic plaque. Growth Differentiation Factor-15 (GDF-15) and Tenascin-C 
      (TNC) play an important role in the initiation of atherosclerotic plaque as well 
      as its rupture. The aim of the study was to evaluate the association between 
      serum GDF-15, TNC, and the risk of ACS among T2DM patients. METHODS: 
      Anthropometric parameters, routine biochemical investigations like liver and 
      renal function tests, lipid profile, and Creatine Kinase-Total (CK-T), Creatine 
      Kinase-MB (CK-MB) were measured in 42 T2DM patients with ACS and 42 T2DM 
      patients. Serum GDF-15 and TNC were measured by Human Sandwich-ELISA kits. 
      RESULTS: Serum GDF-15 and TNC levels were significantly higher in T2DM patients 
      with ACS as compared to T2DM patients. Serum GDF-15 was significantly correlated 
      with waist circumference, diastolic blood pressure, pulse, serum CK-T, and CK-MB. 
      Serum TNC was significantly correlated with the pulse, serum CK-T, CK-MB, 
      high-density lipoprotein-cholesterol, and blood urea nitro GEN. Multivariate 
      linear regression analysis showed that waist circumference was independently 
      positively associated with serum GDF-15. CONCLUSIONS: T2DM patients with higher 
      serum GDF-15 and TNC levels were at higher risk of acute coronary syndrome 
      independent of other cardiovascular risk factors.
CI  - 2020 Murugaiyan Vasanthi, Prashant Shankarrao Adole, Vinay Ramakrishna Pandit, 
      Kolar Vishwanath Vinod, published by CEON/CEES.
FAU - Vasanthi, Murugaiyan
AU  - Vasanthi M
AD  - Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), 
      Department of Biochemistry, Pondicherry, India.
FAU - Adole, Prashant Shankarrao
AU  - Adole PS
AD  - Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), 
      Department of Biochemistry, Pondicherry, India.
FAU - Pandit, Vinay Ramakrishna
AU  - Pandit VR
AD  - Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), 
      Department of Emergency Medicine and Trauma, Pondicherry, India.
FAU - Vinod, Kolar Vishwanath
AU  - Vinod KV
AD  - Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), 
      Department of Medicine, Pondicherry, India.
LA  - eng
PT  - Journal Article
PL  - Serbia
TA  - J Med Biochem
JT  - Journal of medical biochemistry
JID - 101315490
PMC - PMC7710370
OTO - NOTNLM
OT  - acute coronary syndrome
OT  - growth differentiation factor-15
OT  - tenascin-C
OT  - type 2 diabetes mellitus
COIS- Conflict of Interest: The authors stated that they have no conflicts of interest 
      regarding the publication of this article.
EDAT- 2020/12/15 06:00
MHDA- 2020/12/15 06:01
PMCR- 2020/10/02
CRDT- 2020/12/14 10:55
PHST- 2019/11/15 00:00 [received]
PHST- 2019/12/15 00:00 [accepted]
PHST- 2020/12/14 10:55 [entrez]
PHST- 2020/12/15 06:00 [pubmed]
PHST- 2020/12/15 06:01 [medline]
PHST- 2020/10/02 00:00 [pmc-release]
AID - jomb-39-4-2004460V [pii]
AID - 10.5937/jomb0-24662 [doi]
PST - ppublish
SO  - J Med Biochem. 2020 Oct 2;39(4):460-466. doi: 10.5937/jomb0-24662.