PMID- 33312283
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201216
IS  - 1640-5544 (Print)
IS  - 1899-7562 (Electronic)
IS  - 1640-5544 (Linking)
VI  - 74
DP  - 2020 Aug
TI  - Genetics of Muscle Stiffness, Muscle Elasticity and Explosive Strength.
PG  - 143-159
LID - 10.2478/hukin-2020-0027 [doi]
AB  - Muscle stiffness, muscle elasticity and explosive strength are the main 
      components of athletes' performance and they show a sex-based as well as 
      ethnicity variation. Muscle stiffness is thought to be one of the risk factors 
      associated with sports injuries and is less common in females than in males. 
      These observations may be explained by circulating levels of sex hormones and 
      their specific receptors. It has been shown that higher levels of estrogen are 
      associated with lower muscle stiffness responsible for suppression of collagen 
      synthesis. It is thought that these properties, at least in part, depend on 
      genetic factors. Particularly, the gene encoding estrogen receptor 1 (ESR1) is 
      one of the candidates that may be associated with muscle stiffness. Muscle 
      elasticity increases with aging and there is evidence suggesting that titin 
      (encoded by the TTN gene), a protein that is expressed in cardiac and skeletal 
      muscles, is one of the factors responsible for elastic properties of the muscles. 
      Mutations in the TTN gene result in some types of muscular dystrophy or 
      cardiomyopathy. In this context, TTN may be regarded as a promising candidate for 
      studying the elastic properties of muscles in athletes. The physiological 
      background of explosive strength depends not only on the muscle architecture and 
      muscle fiber composition, but also on the central nervous system and 
      functionality of neuromuscular units. These properties are, at least partly, 
      genetically determined. In this context, the ACTN3 gene code for alpha-actinin 3 has 
      been widely researched.
CI  - (c) 2020 Agnieszka Maciejewska-Skrendo, Katarzyna Leznicka, Agata Leonska-Duniec, 
      Michal Wilk, Aleksandra Filip, Pawel Cieszczyk, Marek Sawczuk, published by 
      Sciendo.
FAU - Maciejewska-Skrendo, Agnieszka
AU  - Maciejewska-Skrendo A
AD  - Unit of Molecular Biology, Department of Health and Natural Sciences, Faculty of 
      Physical Culture, Gdansk University of Physical Education and Sport, Gdansk, 
      Poland.
AD  - Institute of Physical Culture Sciences, University of Szczecin, Szczecin, Poland.
FAU - Leznicka, Katarzyna
AU  - Leznicka K
AD  - Unit of Molecular Biology, Department of Health and Natural Sciences, Faculty of 
      Physical Culture, Gdansk University of Physical Education and Sport, Gdansk, 
      Poland.
FAU - Leonska-Duniec, Agata
AU  - Leonska-Duniec A
AD  - Unit of Molecular Biology, Department of Health and Natural Sciences, Faculty of 
      Physical Culture, Gdansk University of Physical Education and Sport, Gdansk, 
      Poland.
FAU - Wilk, Michal
AU  - Wilk M
AD  - Institute of Sport Sciences, Jerzy Kukuczka Academy of Physical Education in 
      Katowice, 40-065 Katowice, Poland.
FAU - Filip, Aleksandra
AU  - Filip A
AD  - Institute of Sport Sciences, Jerzy Kukuczka Academy of Physical Education in 
      Katowice, 40-065 Katowice, Poland.
FAU - Cieszczyk, Pawel
AU  - Cieszczyk P
AD  - Unit of Molecular Biology, Department of Health and Natural Sciences, Faculty of 
      Physical Culture, Gdansk University of Physical Education and Sport, Gdansk, 
      Poland.
FAU - Sawczuk, Marek
AU  - Sawczuk M
AD  - Unit of Molecular Biology, Department of Health and Natural Sciences, Faculty of 
      Physical Culture, Gdansk University of Physical Education and Sport, Gdansk, 
      Poland.
AD  - Institute of Physical Culture Sciences, University of Szczecin, Szczecin, Poland.
LA  - eng
PT  - Journal Article
DEP - 20200831
PL  - Poland
TA  - J Hum Kinet
JT  - Journal of human kinetics
JID - 101513031
PMC - PMC7706646
OTO - NOTNLM
OT  - genetic markers
OT  - genetic polymorphism
OT  - muscle rigidness
OT  - power
OT  - sports genetics
EDAT- 2020/12/15 06:00
MHDA- 2020/12/15 06:01
PMCR- 2020/08/31
CRDT- 2020/12/14 10:56
PHST- 2020/12/14 10:56 [entrez]
PHST- 2020/12/15 06:00 [pubmed]
PHST- 2020/12/15 06:01 [medline]
PHST- 2020/08/31 00:00 [pmc-release]
AID - hukin-2020-0027 [pii]
AID - 10.2478/hukin-2020-0027 [doi]
PST - epublish
SO  - J Hum Kinet. 2020 Aug 31;74:143-159. doi: 10.2478/hukin-2020-0027. eCollection 
      2020 Aug.