PMID- 33313200
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220418
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 8
IP  - 21
DP  - 2020 Nov
TI  - Systemic risk factors correlated with hyperhomocysteinemia for specific MTHFR 
      C677T genotypes and sex in the Chinese population.
PG  - 1455
LID - 10.21037/atm-20-6587 [doi]
LID - 1455
AB  - BACKGROUND: Methyltetrahydrofolate reductase (MTHFR) is a main regulatory enzyme 
      in homocysteine (Hcy) metabolism. A common C677T mutation in the MTHFR gene 
      results in decreased enzyme activity, which contributes to hyperhomocysteinemia 
      (HHcy). Previous studies have shown that HHcy was correlated with various 
      systemic diseases, such as cardiovascular disease, stroke, cancer, renal failure 
      and so on. However, we hypothesized that HHcy in different genotype and sex 
      groups may have different risk factors, which would lead to various pathologic 
      states. Therefore, the aim of this study was to explore systemic information that 
      are correlated with HHcy for specific MTHFR C677T genotypes and sex, which might 
      be useful for predicting and preventing systemic diseases. METHODS: This 
      cross-sectional study was performed through November 2017 to July 2019. A total 
      of 4,534 adults aged 20-75 y were selected for this study. All the participants 
      underwent a physical examination, blood tests and MTHFRC677T genotyping. 
      Multivariable linear regression was performed to explore the risk factors for 
      HHcy for each sex and genotype. RESULTS: The average of Hcy level is higher in 
      the TT genotype than CC and CT genotypes (P=0.000). Multiple linear regression 
      analysis identified the common protective factors (folate and Vit B12) and risk 
      factor (Cr) for HHcy. Besides that, each group has its specific risk 
      factors-female-CT (age, SBP, and Hb), female-TT (SBP and AST); male-CC (age, AST 
      and Hb), male-CT (age and AST) and male-TT (SBP, AST, and Hb). CONCLUSIONS: HHcy 
      was associated with different risk factors for each specific sex and genotype. 
      These risk factors might be useful for predicting and preventing systemic 
      diseases.
CI  - 2020 Annals of Translational Medicine. All rights reserved.
FAU - Xiang, Tianyuan
AU  - Xiang T
AD  - China Health Management Institute, The Second Medical Center & National Clinical 
      Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 
      China.
AD  - Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research 
      at USC, Los Angeles, CA, USA.
FAU - Xiang, Hang
AU  - Xiang H
AD  - Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research 
      at USC, Los Angeles, CA, USA.
AD  - Department of Cardiology, Chinese PLA General Hospital, Beijing, China.
FAU - Yan, Muyang
AU  - Yan M
AD  - Department of Hyperbaric-Oxygen, Chinese PLA General Hospital, Beijing, China.
FAU - Yu, Sheng
AU  - Yu S
AD  - Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical 
      University, Guangzhou, China.
FAU - Horwedel, Matthew John
AU  - Horwedel MJ
AD  - Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard 
      Medical School, Cambridge, MA, USA.
FAU - Li, Yang
AU  - Li Y
AD  - Department of Cardiology, Chinese PLA General Hospital, Beijing, China.
FAU - Zeng, Qiang
AU  - Zeng Q
AD  - China Health Management Institute, The Second Medical Center & National Clinical 
      Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 
      China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC7723589
OTO - NOTNLM
OT  - Hyperhomocysteinemia
OT  - MTHFR polymorphism
OT  - risk factor
OT  - sex
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/atm-20-6587). The authors have no 
      conflicts of interest to declare.
EDAT- 2020/12/15 06:00
MHDA- 2020/12/15 06:01
PMCR- 2020/11/01
CRDT- 2020/12/14 10:59
PHST- 2020/12/14 10:59 [entrez]
PHST- 2020/12/15 06:00 [pubmed]
PHST- 2020/12/15 06:01 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - atm-08-21-1455 [pii]
AID - 10.21037/atm-20-6587 [doi]
PST - ppublish
SO  - Ann Transl Med. 2020 Nov;8(21):1455. doi: 10.21037/atm-20-6587.