PMID- 33317341
OWN - NLM
STAT- MEDLINE
DCOM- 20220202
LR  - 20220202
IS  - 1750-7448 (Electronic)
IS  - 1750-743X (Linking)
VI  - 13
IP  - 3
DP  - 2021 Feb
TI  - Safety of semi-depot house dust mite allergen extract in children and adolescents 
      with allergic rhinitis and asthma.
PG  - 227-239
LID - 10.2217/imt-2020-0232 [doi]
AB  - Aim: Multicenter study to investigate the safety of mite extract product 
      Novo-Helisen Depot, Strengths 1 to 3 (NHD3), as subcutaneous immunotherapy 
      (SCIT), in Chinese children and adolescents with allergic rhinitis (AR) and 
      allergic asthma (AA). Patients & methods: We evaluated SCIT-related adverse 
      events (AEs) during NHD3 14-week initial therapy in children (5-11 years) and 
      adolescents (12-17 years) with perennial symptomatic AR and AA. Results: Among 
      3600 injections in 250 patients, 361/3600 (10.0%) injections caused SCIT-related 
      AEs in 96/250 (38.4%) patients, 321/3600 injections (8.9%) caused local reactions 
      in 89/250 (35.6%) and 40/3600 injections (1.1%) caused systemic reactions in 
      23/250 (9.2%). Conclusion: Initial SCIT treatment using NHD3 was safe and well 
      tolerated in Chinese children and adolescents with AR and AA.
FAU - Xiang, Li
AU  - Xiang L
AD  - Department of Allergy, Beijing Children's Hospital, Beijing 100045, China.
FAU - Liu, Fengxia
AU  - Liu F
AD  - Department of Allergy, Weifang People's Hospital, Weifang 261200, China.
FAU - Zhi, Lili
AU  - Zhi L
AD  - Department of Allergy, Central Hospital of Zibo, Zibo 255020, China.
FAU - Jiang, Weihong
AU  - Jiang W
AD  - Department of Otorhinolaryngology, Xiangya Hospital of Central South University, 
      Changsha 410008, China.
FAU - Liu, Changshan
AU  - Liu C
AD  - Department of Pediatrics, The Second Hospital of Tianjin Medical University, 
      Tianjin 300211, China.
FAU - Xie, Hua
AU  - Xie H
AD  - Department of Respiratory, General Hospital of Northern Theater Command, Shenyang 
      110015, China.
FAU - Zhou, Xiaoqin
AU  - Zhou X
AD  - Department of Pediatrics, Hubei Provincial Maternal & Child Health Hospital, 
      Wuhan 430070, China.
FAU - Sun, Yuemei
AU  - Sun Y
AD  - Department of Allergy, Yantai Yuhuangding Hospital, Yantai 264000, China.
FAU - Zheng, Yuejie
AU  - Zheng Y
AD  - Department of Respiratory, Shenzhen Children's Hospital, Shenzhen 518026, China.
FAU - Zhu, Rongfei
AU  - Zhu R
AD  - Department of Allergy, Tongji Hospital, Tongji Medical College of Huazhong 
      University of Science & Technology, Wuhan 430030, China.
FAU - Tao, Zezhang
AU  - Tao Z
AD  - Department of Otorhinolaryngology, Renmin Hospital of Wuhan University, Wuhan 
      430060, China.
FAU - Xia, Wanmin
AU  - Xia W
AD  - Department of Pediatric Respiratory Medicine, Chengdu Women's and Children's 
      Central Hospital, School of Medicine, University of Electronic Science and 
      Technology of China, Chengdu 611731, China.
FAU - Lai, He
AU  - Lai H
AD  - Department of Allergy, The Second Affiliated Hospital of Guangzhou Medical 
      University, Guangzhou 510260, China.
FAU - Wei, Qingyu
AU  - Wei Q
AD  - Department of Allergy, General Hospital of Northern Theater Command, Shenyang 
      110003, China.
FAU - Cheng, Lei
AU  - Cheng L
AD  - Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated 
      Hospital, Nanjing Medical University, Nanjing 210029, China.
AD  - International Centre for Allergy Research, Nanjing Medical University, Nanjing 
      210029, China.
FAU - Tang, Yu
AU  - Tang Y
AD  - Department of Respiratory, Children's Hospital Affiliated to Zhengzhou 
      University, Zhengzhou 450018, China.
FAU - Xu, Rui
AU  - Xu R
AD  - Department of Allergy of Otorhinolaryngology Hospital, The First Affiliated 
      Hospital of Sun Yat-sen University, Guangzhou 510080, China.
FAU - Huang, Huijie
AU  - Huang H
AD  - Department of Allergy, Beijing Children's Hospital, Beijing 100045, China.
FAU - Zhou, Queena
AU  - Zhou Q
AD  - Medical Affairs, Merck Serono Co., Ltd, Beijing 100016, China.
FAU - Chang, Peter
AU  - Chang P
AD  - Global Biostatistics, Epidemiology, Medical Writing (GBEM), Merck Serono Co., 
      Ltd, Beijing 100016, China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20201215
PL  - England
TA  - Immunotherapy
JT  - Immunotherapy
JID - 101485158
RN  - 0 (Antigens, Dermatophagoides)
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Antigens, Dermatophagoides/immunology/*therapeutic use
MH  - Asthma/immunology/*therapy
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Desensitization, Immunologic
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Female
MH  - Humans
MH  - Injections, Subcutaneous
MH  - Male
MH  - Medication Adherence
MH  - Pyroglyphidae/immunology
MH  - Rhinitis, Allergic/immunology/*therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - adolescents
OT  - allergic rhinitis
OT  - asthma
OT  - children
OT  - house dust mite
OT  - multicenter
OT  - safety
OT  - semi-depot allergen extract
OT  - subcutaneous immunotherapy
OT  - tolerability
EDAT- 2020/12/16 06:00
MHDA- 2022/02/03 06:00
CRDT- 2020/12/15 05:38
PHST- 2020/12/16 06:00 [pubmed]
PHST- 2022/02/03 06:00 [medline]
PHST- 2020/12/15 05:38 [entrez]
AID - 10.2217/imt-2020-0232 [doi]
PST - ppublish
SO  - Immunotherapy. 2021 Feb;13(3):227-239. doi: 10.2217/imt-2020-0232. Epub 2020 Dec 
      15.