PMID- 33317547
OWN - NLM
STAT- MEDLINE
DCOM- 20201229
LR  - 20221207
IS  - 1477-7525 (Electronic)
IS  - 1477-7525 (Linking)
VI  - 18
IP  - 1
DP  - 2020 Dec 14
TI  - Impact of COVID-19 on health-related quality of life in patients with 
      cardiovascular disease: a multi-ethnic Asian study.
PG  - 387
LID - 10.1186/s12955-020-01640-5 [doi]
LID - 387
AB  - BACKGROUND: Little is known about the impact of the global coronavirus 
      disease-2019 (COVID-19) pandemic on patients with cardiovascular disease (CVD), 
      the biggest global killer and major risk factor for severe COVID-19 infections. 
      We aim to explore the indirect consequences of COVID-19 on health-related quality 
      of life (HRQoL) of patients with CVD. METHODS: Eighty-one adult outpatients with 
      CVD were assessed using the EQ-5D, a generic health status instrument with five 
      dimensions (mobility, self-care, usual activities, pain/discomfort, 
      anxiety/depression), before and during the pandemic. Changes in the EQ-5D 
      dimensional responses were compared categorically as well as using the 
      dimension-specific sum-score (range 1-3, with a higher score indicating worse 
      health). The responses and sum-score were compared using the exact test of 
      symmetry and the paired t-test, respectively. RESULTS: These patients [mean age 
      (SD) 59.8 (10.5); 92.6% males; 56% New York Heart Association (NYHA) functional 
      class I] had coronary artery disease (69%), heart failure (28%), or arrhythmias 
      (15%). None experienced change in NYHA class between assessments. About 30% and 
      38% of patients reported problems with at least one of the EQ-5D dimensions 
      pre-pandemic and during the pandemic, respectively. The highest increase in 
      health problems was reported for anxiety/depression (12.5% pre-pandemic vs 23.5% 
      during pandemic; p = 0.035) with mean domain-specific score from 1.12 (SD 0.33) 
      to 1.25 (SD 0.46) (standardized effect size = 0.373, p = 0.012). There was no 
      meaningful change in other dimensions as well as overall HRQoL. CONCLUSION: The 
      COVID-19 pandemic is associated with a significant worsening of the mental health 
      of patients with CVD.
FAU - Lim, Shir Lynn
AU  - Lim SL
AUID- ORCID: 0000-0002-1151-2357
AD  - Department of Cardiology, National University Heart Center, Singapore, Singapore. 
      shir_lynn_lim@nuhs.edu.sg.
AD  - Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore. 
      shir_lynn_lim@nuhs.edu.sg.
FAU - Woo, Kai Lee
AU  - Woo KL
AD  - Department of Cardiology, National University Heart Center, Singapore, Singapore.
FAU - Lim, Eleanor
AU  - Lim E
AD  - Department of Cardiology, National University Heart Center, Singapore, Singapore.
FAU - Ng, Faclin
AU  - Ng F
AD  - Department of Cardiology, National University Heart Center, Singapore, Singapore.
FAU - Chan, Mark Y
AU  - Chan MY
AD  - Department of Cardiology, National University Heart Center, Singapore, Singapore.
AD  - Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore.
FAU - Gandhi, Mihir
AU  - Gandhi M
AD  - Biostatistics, Singapore Clinical Research Institute, Singapore, Singapore.
AD  - Center for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore.
AD  - Global Health Group, Center for Child Health Research, Tampere University, 
      Tampere, Finland.
LA  - eng
PT  - Journal Article
DEP - 20201214
PL  - England
TA  - Health Qual Life Outcomes
JT  - Health and quality of life outcomes
JID - 101153626
SB  - IM
MH  - Activities of Daily Living
MH  - Adult
MH  - Aged
MH  - Anxiety/complications
MH  - Asian People
MH  - COVID-19/*psychology
MH  - Cardiovascular Diseases/complications/ethnology/*psychology
MH  - Depression/complications
MH  - Female
MH  - *Health Status
MH  - Health Surveys
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Pain/etiology
MH  - Pandemics
MH  - *Quality of Life
MH  - Self Care
MH  - Singapore
PMC - PMC7734458
OTO - NOTNLM
OT  - COVID-19
OT  - Cardiovascular
OT  - EQ-5D
OT  - Health-related quality of life
OT  - Psychological health
COIS- None directly related to this work. SLL is supported by National University 
      Health System Clinician Scientist Program; she has received research grants from 
      National University Health System, National Kidney Foundation of Singapore and 
      Singapore Heart Foundation. MG is a member of EuroQol Group. KLW, EL, FN and MC 
      report no conflicts of interest.
EDAT- 2020/12/16 06:00
MHDA- 2020/12/30 06:00
PMCR- 2020/12/14
CRDT- 2020/12/15 05:40
PHST- 2020/08/16 00:00 [received]
PHST- 2020/12/07 00:00 [accepted]
PHST- 2020/12/15 05:40 [entrez]
PHST- 2020/12/16 06:00 [pubmed]
PHST- 2020/12/30 06:00 [medline]
PHST- 2020/12/14 00:00 [pmc-release]
AID - 10.1186/s12955-020-01640-5 [pii]
AID - 1640 [pii]
AID - 10.1186/s12955-020-01640-5 [doi]
PST - epublish
SO  - Health Qual Life Outcomes. 2020 Dec 14;18(1):387. doi: 
      10.1186/s12955-020-01640-5.