PMID- 33317932
OWN - NLM
STAT- MEDLINE
DCOM- 20211028
LR  - 20211028
IS  - 2173-9188 (Electronic)
IS  - 1130-1406 (Linking)
VI  - 38
IP  - 1
DP  - 2021 Jan-Mar
TI  - Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 associated with 
      acquired immunodeficiency syndrome: A case report.
PG  - 5-8
LID - S1130-1406(20)30046-2 [pii]
LID - 10.1016/j.riam.2020.09.003 [doi]
AB  - BACKGROUND: Paracoccidioidomycosis (PCM) is an endemic disease in Latin America. 
      In immunocompetent hosts, PCM occurs in two main clinical forms: acute and 
      chronic. However, in HIV-infected patients PCM may show up simultaneous 
      manifestations of acute and chronic forms. CASE REPORT: We present the case of a 
      patient diagnosed with HIV who had disseminated skin lesions and generalized 
      lymphadenopathy, as well as respiratory and central nervous system involvement. 
      The PCM diagnosis was confirmed by direct KOH examination, double immunodiffusion 
      and the isolation of the fungus in samples of an abscess in the subcostal region. 
      The isolate was identified as Paracoccidioides brasiliensis S1 by 
      species-specific PCR using primers for protein-coding gene GP43 (exon 2) followed 
      by PCR-RFLP of the alpha-tubulin gene. CONCLUSIONS: There are few data in 
      literature reporting species-specific molecular identification of 
      Paracoccidioides in HIV/PCM patients. Therefore, this case report may contribute 
      to improve the knowledge about this severe disease, its causative cryptic 
      species, and its consequences to patients.
CI  - Copyright (c) 2020 Asociacion Espanola de Micologia. Publicado por Elsevier Espana, 
      S.L.U. All rights reserved.
FAU - Pecanha, Paulo Mendes
AU  - Pecanha PM
AD  - Universidade Federal do Espirito Santo-UFES, Brazil.
FAU - Bahiense, Isabela Cruz
AU  - Bahiense IC
AD  - Universidade Federal do Espirito Santo-UFES, Brazil.
FAU - Kruschewsky, Wdson Luis Lima
AU  - Kruschewsky WLL
AD  - Universidade Federal do Espirito Santo-UFES, Brazil.
FAU - Biasutti, Claudia
AU  - Biasutti C
AD  - Hospital Universitario Cassiano Antonio Moraes-UFES, Brazil.
FAU - Junior, Carlos Urbano Goncalves Ferreira
AU  - Junior CUGF
AD  - Hospital Universitario Cassiano Antonio Moraes-UFES, Brazil.
FAU - Pinheiro, Breno Goncalves
AU  - Pinheiro BG
AD  - Universidade Federal de Sao Paulo-UNIFESP, Brazil.
FAU - Maifrede, Simone Bravim
AU  - Maifrede SB
AD  - Universidade Federal do Espirito Santo-UFES, Brazil.
FAU - Camargo, Zoilo Pires de
AU  - Camargo ZP
AD  - Universidade Federal de Sao Paulo-UNIFESP, Brazil.
FAU - Rodrigues, Anderson Messias
AU  - Rodrigues AM
AD  - Universidade Federal de Sao Paulo-UNIFESP, Brazil.
FAU - Grao-Velloso, Tania Regina
AU  - Grao-Velloso TR
AD  - Universidade Federal do Espirito Santo-UFES, Brazil.
FAU - Falqueto, Aloisio
AU  - Falqueto A
AD  - Universidade Federal do Espirito Santo-UFES, Brazil.
FAU - Goncalves, Sarah Santos
AU  - Goncalves SS
AD  - Universidade Federal do Espirito Santo-UFES, Brazil. Electronic address: 
      sarah.tavares@ufes.br.
LA  - eng
PT  - Case Reports
DEP - 20201213
PL  - Spain
TA  - Rev Iberoam Micol
JT  - Revista iberoamericana de micologia
JID - 9425531
SB  - IM
MH  - *Acquired Immunodeficiency Syndrome/complications
MH  - Humans
MH  - *Paracoccidioides/genetics
MH  - *Paracoccidioidomycosis/complications/diagnosis
MH  - Polymorphism, Restriction Fragment Length
MH  - Species Specificity
OTO - NOTNLM
OT  - Co-infection
OT  - Coinfeccion
OT  - HIV
OT  - Paracoccidioides brasiliensis S1
OT  - Paracoccidioidomicosis
OT  - Paracoccidioidomycosis
OT  - VIH
EDAT- 2020/12/16 06:00
MHDA- 2021/10/29 06:00
CRDT- 2020/12/15 05:47
PHST- 2020/06/05 00:00 [received]
PHST- 2020/08/03 00:00 [revised]
PHST- 2020/09/14 00:00 [accepted]
PHST- 2020/12/16 06:00 [pubmed]
PHST- 2021/10/29 06:00 [medline]
PHST- 2020/12/15 05:47 [entrez]
AID - S1130-1406(20)30046-2 [pii]
AID - 10.1016/j.riam.2020.09.003 [doi]
PST - ppublish
SO  - Rev Iberoam Micol. 2021 Jan-Mar;38(1):5-8. doi: 10.1016/j.riam.2020.09.003. Epub 
      2020 Dec 13.