PMID- 33322645
OWN - NLM
STAT- MEDLINE
DCOM- 20210423
LR  - 20210423
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 12
DP  - 2020 Dec 11
TI  - Anti-Inflammatory Effects of Asian Fawn Lily (Erythronium japonicum) Extract on 
      Lipopolysaccharide-Induced Depressive-Like Behavior in Mice.
LID - 10.3390/nu12123809 [doi]
LID - 3809
AB  - Neuroinflammation is associated with an increased risk of depression. 
      Lipopolysaccharide (LPS) treatment is known to induce pro-inflammatory cytokine 
      secretion and a depressive-like phenotype in mice. Although Erythronium japonicum 
      exhibits various health benefits, the role of E. japonicum extract (EJE) in 
      inflammation-associated depression is unknown. This study aimed to explore the 
      anti-inflammatory effect of EJE on LPS-induced depressive symptoms in mice using 
      the open field test (OFT), passive avoidance test (PAT), tail suspension test 
      (TST), and forced swim test (FST). LPS-treated mice had significantly increased 
      immobility time in the TST and FST, decreased step-through latency time in the 
      PAT, and decreased locomotor activity in the OFT. However, administration of 100 
      and 300 mg/kg of EJE significantly improved these depressive-like behaviors. EJE 
      also prevented the increase in mRNA levels of tumor necrosis factor-alpha (TNF-alpha), 
      interleukin-1beta (IL-1beta), IL-6, and monocyte chemoattractant protein-1 (MCP-1), and 
      the decrease in IL-10 levels by inhibiting nuclear factor-kappaB (NF-kappaB) subunit p65 
      phosphorylation. Additionally, LPS-treated mice showed markedly decreased 
      brain-derived neurotrophic factor (BDNF) levels and phosphorylation of 
      phosphoinositide 3-kinase (PI3K) and Akt, while EJE treatment significantly 
      increased these levels in the hippocampus. These results suggest that EJE 
      ameliorated LPS-induced depressive-like behavior by reducing LPS-induced 
      neuroinflammation and activating the BDNF-PI3K/Akt pathway.
FAU - Lim, Dong Wook
AU  - Lim DW
AD  - Research Division of Food Functionality, Korea Food Research Institute, Wanju 
      55365, Korea.
FAU - Park, Joon
AU  - Park J
AD  - Research Division of Food Functionality, Korea Food Research Institute, Wanju 
      55365, Korea.
AD  - Division of Food Biotechnology, University of Science & Technology, Daejeon 
      34113, Korea.
FAU - Han, Daeseok
AU  - Han D
AD  - Research Division of Food Functionality, Korea Food Research Institute, Wanju 
      55365, Korea.
FAU - Lee, Jaekwang
AU  - Lee J
AUID- ORCID: 0000-0002-4427-5212
AD  - Research Division of Food Functionality, Korea Food Research Institute, Wanju 
      55365, Korea.
FAU - Kim, Yun Tai
AU  - Kim YT
AUID- ORCID: 0000-0002-3404-6977
AD  - Research Division of Food Functionality, Korea Food Research Institute, Wanju 
      55365, Korea.
AD  - Division of Food Biotechnology, University of Science & Technology, Daejeon 
      34113, Korea.
FAU - Lee, Changho
AU  - Lee C
AD  - Research Division of Food Functionality, Korea Food Research Institute, Wanju 
      55365, Korea.
LA  - eng
GR  - E0164501-05/Korea Food Research Institute/
GR  - E0164502-05/Korea Food Research Institute/
PT  - Journal Article
DEP - 20201211
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Plant Extracts)
RN  - EC 2.7.1.137 (Phosphatidylinositol 3-Kinase)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Antidepressive Agents/*pharmacology
MH  - Avoidance Learning/drug effects
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Depression/chemically induced/*drug therapy
MH  - Disease Models, Animal
MH  - Hindlimb Suspension
MH  - *Liliaceae
MH  - Lipopolysaccharides
MH  - Locomotion/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Phosphatidylinositol 3-Kinase/metabolism
MH  - Plant Extracts/*pharmacology
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Signal Transduction/drug effects
MH  - Swimming
PMC - PMC7764803
OTO - NOTNLM
OT  - Erythronium japonicum
OT  - anti-inflammation
OT  - depression
OT  - lipopolysaccharide
COIS- The authors declare no conflict of interest.
EDAT- 2020/12/17 06:00
MHDA- 2021/04/24 06:00
PMCR- 2020/12/11
CRDT- 2020/12/16 01:04
PHST- 2020/11/02 00:00 [received]
PHST- 2020/12/09 00:00 [revised]
PHST- 2020/12/10 00:00 [accepted]
PHST- 2020/12/16 01:04 [entrez]
PHST- 2020/12/17 06:00 [pubmed]
PHST- 2021/04/24 06:00 [medline]
PHST- 2020/12/11 00:00 [pmc-release]
AID - nu12123809 [pii]
AID - nutrients-12-03809 [pii]
AID - 10.3390/nu12123809 [doi]
PST - epublish
SO  - Nutrients. 2020 Dec 11;12(12):3809. doi: 10.3390/nu12123809.