PMID- 33322753 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201227 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 9 IP - 12 DP - 2020 Dec 12 TI - Efficacy and Safety of Houttuynia Eye Drops Atomization Treatment for Meibomian Gland Dysfunction-Related Dry Eye Disease: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. LID - 10.3390/jcm9124022 [doi] LID - 4022 AB - PURPOSE: To evaluate the efficacy and safety of Houttuynia eye drops (a Chinese traditional medicine) atomization treatment in meibomian gland dysfunction (MGD)-related dry eye disease (DED) patients. METHODS: A total of 240 eligible patients diagnosed with MGD-related DED were assigned either Houttuynia eye drops or placebo for atomization once daily for four weeks in a multi-center, randomized, double-blind, placebo-controlled clinical study. Primary outcome evaluations used included eye symptom score (using the Chinese Dry Eye Questionnaire), meibum quality, and tear break-up time (TBUT), while safety evaluations included adverse events (AEs), visual acuity, and intraocular pressure monitoring. Indicators were measured at baseline as well as one week, two weeks, and four weeks after treatment. RESULTS: Primary outcome measures of the Houttuynia group were improved compared with their placebo counterparts following four-week treatment. Eye symptom scores were significantly reduced relative to the baseline in the Houttuynia group (mean +/- standard error of the mean, 9.00 +/- 0.61) compared with the placebo group (6.29 +/- 0.55; p = 0.0018). Reduction in meibum quality score in the Houttuynia group (0.91 +/- 0.10) was also significantly higher compared with the placebo group (0.57 +/- 0.10; p = 0.0091), while TBUT in the treatment group (6.30 +/- 0.22) was also longer than in the latter (5.60 +/- 0.24; p = 0.0192). No medication-related adverse events were observed. CONCLUSIONS: Atomization treatment with Houttuynia eye drops is both clinically and statistically effective for the treatment of mild to moderate MGD-related DED patients. This approach is generally safe and was tolerated well by patients. FAU - Liu, Zhaolin AU - Liu Z AUID- ORCID: 0000-0001-7468-4474 AD - Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China. AD - Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China. AD - Department of Ocular Surface, Xiamen University Affiliated Xiamen Eye Center, Xiamen 361102, China. FAU - Jin, Ming AU - Jin M AD - Department of Ophthalmology, China-Japan Friendship Hospital, Beijing100029, China. FAU - Li, Ying AU - Li Y AD - Department of Ophthalmology, Peking Union Medical College Hospital, Beijing 100006, China. FAU - Liu, Jun AU - Liu J AD - Department of Ophthalmology, Shenzhen Eye Hospital, Shenzhen 518040, China. FAU - Xiao, Xianghua AU - Xiao X AD - Department of Ophthalmology, Xi'an First Hospital, Shaanxi Eye Research Institute, Shaanxi 710001, China. FAU - Bi, Hongsheng AU - Bi H AD - Department of Ophthalmology, Shandong University of Traditional Chinese Medicine Affiliated Eye Hospital, Jinan 250004, China. FAU - Pan, Zhiqiang AU - Pan Z AD - Department of Ophthalmology, Capital Medical University Affiliated Beijing Tongren Hospital, Beijing 100730, China. FAU - Shi, Huijun AU - Shi H AD - Department of Ophthalmology, Hebei Eye Hospital, Xingtai 054001, China. FAU - Xie, Xiaofeng AU - Xie X AD - Department of Ophthalmology, Shandong University of Traditional Chinese Medicine Affiliated Eye Hospital, Jinan 250004, China. FAU - Zhang, Minglian AU - Zhang M AD - Department of Ophthalmology, Hebei Eye Hospital, Xingtai 054001, China. FAU - Gao, Xuemin AU - Gao X AD - Technical Center for Drug Research and Evaluation of China Association of Traditional Chinese Medicine, Beijing 100061, China. FAU - Li, Lei AU - Li L AD - Technical Center for Drug Research and Evaluation of China Association of Traditional Chinese Medicine, Beijing 100061, China. FAU - Ouyang, Weijie AU - Ouyang W AD - Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China. AD - Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China. AD - Department of Ocular Surface, Xiamen University Affiliated Xiamen Eye Center, Xiamen 361102, China. FAU - Tang, Liying AU - Tang L AD - Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China. AD - Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China. AD - Department of Ocular Surface, Xiamen University Affiliated Xiamen Eye Center, Xiamen 361102, China. FAU - Wu, Jieli AU - Wu J AD - Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China. AD - Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China. AD - Department of Ocular Surface, Xiamen University Affiliated Xiamen Eye Center, Xiamen 361102, China. FAU - Yang, Yiran AU - Yang Y AD - Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China. AD - Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China. AD - Department of Ocular Surface, Xiamen University Affiliated Xiamen Eye Center, Xiamen 361102, China. FAU - Hu, Jiaoyue AU - Hu J AD - Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China. AD - Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China. AD - Department of Ocular Surface, Xiamen University Affiliated Xiamen Eye Center, Xiamen 361102, China. FAU - Liu, Zuguo AU - Liu Z AD - Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China. AD - Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China. AD - Department of Ocular Surface, Xiamen University Affiliated Xiamen Eye Center, Xiamen 361102, China. LA - eng GR - 2018YFA0107304/National Key R&D Program of China/ PT - Journal Article DEP - 20201212 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC7763017 OTO - NOTNLM OT - Houttuynia OT - dry eye OT - meibomian gland dysfunction OT - ultrasonic atomization COIS- The authors report no conflicts of interest in this work. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. EDAT- 2020/12/17 06:00 MHDA- 2020/12/17 06:01 PMCR- 2020/12/12 CRDT- 2020/12/16 01:04 PHST- 2020/09/15 00:00 [received] PHST- 2020/12/01 00:00 [revised] PHST- 2020/12/08 00:00 [accepted] PHST- 2020/12/16 01:04 [entrez] PHST- 2020/12/17 06:00 [pubmed] PHST- 2020/12/17 06:01 [medline] PHST- 2020/12/12 00:00 [pmc-release] AID - jcm9124022 [pii] AID - jcm-09-04022 [pii] AID - 10.3390/jcm9124022 [doi] PST - epublish SO - J Clin Med. 2020 Dec 12;9(12):4022. doi: 10.3390/jcm9124022.