PMID- 33323444
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 10
IP  - 12
DP  - 2020 Dec 15
TI  - Different exposure metrics of rotating night shift work and hyperhomocysteinaemia 
      among Chinese steelworkers: a cross-sectional study.
PG  - e041576
LID - 10.1136/bmjopen-2020-041576 [doi]
LID - e041576
AB  - OBJECTIVE: To examine the associations of rotating night shift work with 
      hyperhomocysteinaemia (HHcy) odds by different exposure metrics. DESIGN: 
      Cross-sectional study. SETTING: Occupational physical examination centre for 
      steel production workers, Tangshan, China. PARTICIPANTS: A total of 6846 
      steelworkers, aged 22-60 years, from the baseline survey of a Chinese 
      occupational cohort. PRIMARY AND SECONDARY OUTCOME MEASURES: Different exposure 
      metrics of night shift work, including current shift status, duration of night 
      shifts (years), cumulative number of night shifts (nights), cumulative length of 
      night shifts (hours), average frequency of night shifts (nights/month), average 
      length of night shifts (hours/night) and percentage of hours on night shifts, 
      were used to examine the effects of past and current night shift work on HHcy 
      odds. The total homocysteine concentration in the plasma above 15 micromol/L was 
      defined as HHcy. RESULTS: Compared with those who never worked night shifts, 
      current night shift workers had elevated odds of HHcy (OR 1.23, 95% CI 1.06 to 
      1.44). Considering a person's lifetime work schedule and compared with 
      individuals who never worked night shifts, duration of night shifts >28 years (OR 
      1.35, 95% CI 1.12 to 1.61), average frequency of night shifts >7 nights/month (OR 
      1.25, 95% CI 1.07 to 1.47) and percentage of hours on night shifts >30% (OR 1.23, 
      95% CI 1.05 to 1.43) were associated with higher HHcy odds. The duration of night 
      shifts >20 years and the average frequency of night shifts >7 nights/month could 
      significantly increase the odds of HHcy regardless of whether the average length 
      of night shifts was greater than 8 hours/night. After stratification by sex, no 
      significant association was found in female workers between different exposure 
      metrics of night shift work and HHcy. CONCLUSIONS: Long duration and high 
      frequency of night shift work are associated with higher HHcy odds among male 
      steelworkers.
CI  - (c) Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Zhang, Shengkui
AU  - Zhang S
AUID- ORCID: 0000-0003-0859-6884
AD  - Department of Epidemiology and Health Statistics, School of Public Health, North 
      China University of Science and Technology, Tangshan, Hebei Province, China.
FAU - Wang, Yongbin
AU  - Wang Y
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Xinxiang Medical University, Xinxiang, Henan Province, China.
FAU - Li, Qinglin
AU  - Li Q
AD  - Department of Epidemiology and Health Statistics, School of Public Health, North 
      China University of Science and Technology, Tangshan, Hebei Province, China.
FAU - Wang, Zhende
AU  - Wang Z
AD  - Department of Epidemiology and Health Statistics, School of Public Health, North 
      China University of Science and Technology, Tangshan, Hebei Province, China.
FAU - Wang, Han
AU  - Wang H
AD  - Department of Epidemiology and Health Statistics, School of Public Health, North 
      China University of Science and Technology, Tangshan, Hebei Province, China.
FAU - Xue, Chao
AU  - Xue C
AD  - Department of Epidemiology and Health Statistics, School of Public Health, North 
      China University of Science and Technology, Tangshan, Hebei Province, China.
FAU - Zhu, Ying
AU  - Zhu Y
AUID- ORCID: 0000-0003-0949-0475
AD  - Department of Epidemiology and Health Statistics, School of Public Health, North 
      China University of Science and Technology, Tangshan, Hebei Province, China.
FAU - Guan, Weijun
AU  - Guan W
AD  - Department of Epidemiology and Health Statistics, School of Public Health, North 
      China University of Science and Technology, Tangshan, Hebei Province, China.
FAU - Yuan, Juxiang
AU  - Yuan J
AD  - Department of Epidemiology and Health Statistics, School of Public Health, North 
      China University of Science and Technology, Tangshan, Hebei Province, China 
      yuanjx@ncst.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201215
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Adult
MH  - Benchmarking
MH  - China/epidemiology
MH  - Circadian Rhythm
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - *Shift Work Schedule/adverse effects
MH  - Work Schedule Tolerance
MH  - Young Adult
PMC - PMC7745529
OTO - NOTNLM
OT  - epidemiology
OT  - occupational & industrial medicine
OT  - public health
COIS- Competing interests: None declared.
EDAT- 2020/12/17 06:00
MHDA- 2021/05/15 06:00
PMCR- 2020/12/15
CRDT- 2020/12/16 05:28
PHST- 2020/12/16 05:28 [entrez]
PHST- 2020/12/17 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/12/15 00:00 [pmc-release]
AID - bmjopen-2020-041576 [pii]
AID - 10.1136/bmjopen-2020-041576 [doi]
PST - epublish
SO  - BMJ Open. 2020 Dec 15;10(12):e041576. doi: 10.1136/bmjopen-2020-041576.