PMID- 33323495
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20220102
IS  - 1549-5485 (Electronic)
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 28
IP  - 1
DP  - 2021 Jan
TI  - mTOR inhibition impairs extinction memory reconsolidation.
PG  - 1-6
LID - 10.1101/lm.052068.120 [doi]
AB  - Fear-motivated avoidance extinction memory is prone to hippocampal brain-derived 
      neurotrophic factor (BDNF)-dependent reconsolidation upon recall. Here, we show 
      that extinction memory recall activates mammalian target of rapamycin (mTOR) in 
      dorsal CA1, and that post-recall inhibition of this kinase hinders avoidance 
      extinction memory persistence and recovers the learned aversive response. 
      Importantly, coadministration of recombinant BDNF impedes the behavioral effect 
      of hippocampal mTOR inhibition. Our results demonstrate that mTOR signaling is 
      necessary for fear-motivated avoidance extinction memory reconsolidation and 
      suggests that BDNF acts downstream mTOR in a protein synthesis-independent manner 
      to maintain the reactivated extinction memory trace.
CI  - (c) 2021 Radiske et al.; Published by Cold Spring Harbor Laboratory Press.
FAU - Radiske, Andressa
AU  - Radiske A
AD  - Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do 
      Norte, RN 59056-450 Natal, Brazil.
FAU - Gonzalez, Maria Carolina
AU  - Gonzalez MC
AD  - Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do 
      Norte, RN 59056-450 Natal, Brazil.
AD  - Edmond and Lily Safra International Institute of Neuroscience, RN 59280-000 
      Macaiba, Brazil.
FAU - Noga, Diana A
AU  - Noga DA
AD  - Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do 
      Norte, RN 59056-450 Natal, Brazil.
FAU - Rossato, Janine I
AU  - Rossato JI
AD  - Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do 
      Norte, RN 59056-450 Natal, Brazil.
AD  - Departament of Physiology, Federal University of Rio Grande do Norte, RN 
      59064-741 Natal, Brazil.
FAU - Bevilaqua, Lia R M
AU  - Bevilaqua LRM
AD  - Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do 
      Norte, RN 59056-450 Natal, Brazil.
FAU - Cammarota, Martin
AU  - Cammarota M
AD  - Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do 
      Norte, RN 59056-450 Natal, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201215
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (Recombinant Proteins)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism/*pharmacology
MH  - CA1 Region, Hippocampal/drug effects/*metabolism
MH  - Extinction, Psychological/drug effects/*physiology
MH  - Fear/drug effects/physiology
MH  - Memory Consolidation/drug effects/*physiology
MH  - Mental Recall/drug effects/*physiology
MH  - Protein Kinase Inhibitors/*pharmacology
MH  - Recombinant Proteins
MH  - Signal Transduction/drug effects/*physiology
MH  - TOR Serine-Threonine Kinases/*antagonists & inhibitors/*metabolism
PMC - PMC7747651
EDAT- 2020/12/17 06:00
MHDA- 2021/10/26 06:00
PMCR- 2022/01/01
CRDT- 2020/12/16 05:28
PHST- 2020/06/01 00:00 [received]
PHST- 2020/09/10 00:00 [accepted]
PHST- 2020/12/16 05:28 [entrez]
PHST- 2020/12/17 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 28/1/1 [pii]
AID - LM052068Rad [pii]
AID - 10.1101/lm.052068.120 [doi]
PST - epublish
SO  - Learn Mem. 2020 Dec 15;28(1):1-6. doi: 10.1101/lm.052068.120. Print 2021 Jan.