PMID- 33324612 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201217 IS - 2296-2646 (Print) IS - 2296-2646 (Electronic) IS - 2296-2646 (Linking) VI - 8 DP - 2020 TI - Preparation of Electrochemical Sensor Based on Zinc Oxide Nanoparticles for Simultaneous Determination of AA, DA, and UA. PG - 592538 LID - 10.3389/fchem.2020.592538 [doi] LID - 592538 AB - ZnO nanoparticles (NPs) were synthesized using a hydrothermal method. Scanning electron microscope (SEM) and X-ray diffraction have been used for characterizing the synthesized ZnO NPs. An electrochemical sensor was fabricated using ZnO NPs-modified glassy carbon electrode for simultaneous determination of ascorbic acid (AA), dopamine (DA), and uric acid (UA). The proposed electrochemical sensor exhibited excellent detection performance toward three analytes, demonstrating that it can potentially be applied in clinical applications. The results indicated the ZnO NPs-modified electrode can detect AA in the concentrations range between 50 and 1,000 muM. The ZnO NPs-modified electrode can detect DA in the concentrations range between 2 and 150 muM. The ZnO NPs-modified electrode can detect UA in the concentrations range between 0.2 and 150 muM. The limits of detections of AA, DA, and UA using ZnO NPs-modified electrode were calculated to be 18.4, 0.75, and 0.11 muM, respectively. CI - Copyright (c) 2020 Pan, Zuo, Hou, Huang and Huang. FAU - Pan, Yuanzhi AU - Pan Y AD - National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Department of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China. AD - Central Academe, Shanghai Electric Group Co., Ltd., Shanghai, China. AD - Zhenjiang Hongxiang Automation Technology Co., Ltd., Zhenjiang, China. FAU - Zuo, Junli AU - Zuo J AD - Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong School of Medicine, Shanghai, China. FAU - Hou, Zhongyu AU - Hou Z AD - National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Department of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China. FAU - Huang, Yizhong AU - Huang Y AD - School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore. FAU - Huang, Cancan AU - Huang C AD - Beijing Kanghong Biomedical Co., Ltd., Beijing, China. LA - eng PT - Journal Article DEP - 20201125 PL - Switzerland TA - Front Chem JT - Frontiers in chemistry JID - 101627988 PMC - PMC7723903 OTO - NOTNLM OT - ascorbic acid OT - dopamine OT - electrochemical sensor OT - uric acid OT - zinc oxide EDAT- 2020/12/17 06:00 MHDA- 2020/12/17 06:01 PMCR- 2020/01/01 CRDT- 2020/12/16 05:37 PHST- 2020/08/07 00:00 [received] PHST- 2020/08/27 00:00 [accepted] PHST- 2020/12/16 05:37 [entrez] PHST- 2020/12/17 06:00 [pubmed] PHST- 2020/12/17 06:01 [medline] PHST- 2020/01/01 00:00 [pmc-release] AID - 10.3389/fchem.2020.592538 [doi] PST - epublish SO - Front Chem. 2020 Nov 25;8:592538. doi: 10.3389/fchem.2020.592538. eCollection 2020.