PMID- 33324849
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2470-1343 (Electronic)
IS  - 2470-1343 (Linking)
VI  - 5
IP  - 48
DP  - 2020 Dec 8
TI  - Characterization and Cytotoxic Effect of Biosurfactants Obtained from Different 
      Sources.
PG  - 31381-31390
LID - 10.1021/acsomega.0c04933 [doi]
AB  - In this work, five biosurfactant extracts, obtained from different sources, all 
      of them with demonstrated antimicrobial properties, were characterized and 
      subjected to a cytotoxic study using mouse fibroblast cells (NCTC clone 929). 
      Biosurfactant extracts obtained directly from corn steep water (CSW) showed 
      similar surfactant characteristics to those of the extracellular biosurfactant 
      extract produced by Bacillus isolated from CSW and grown in tryptic soy broth, 
      observing that they are amphoteric, consisting of viscous and yellowish liquid 
      with no foaming capacity. Contrarily, cell-bound biosurfactant extracts produced 
      from Lactobacillus pentosus or produced by Bacillus sp isolated from CSW are 
      nonionic, consisting of a white powder with foaming capacity. All the 
      biosurfactants possess a similar fatty acid composition. The cytotoxic test 
      revealed that the extracts under evaluation, at a concentration of 1 g/L, were 
      not cytotoxic for fibroblasts (fibroblast growth > 90%). The biosurfactant 
      extract obtained from CSW with ethyl acetate, at 1 g/L, showed the highest 
      cytotoxic effect but above the cytotoxicity limit established by the 
      UNE-EN-ISO10993-5. It is remarkable that the cell-bound biosurfactant produced by 
      L. pentosus, at a concentration of 1 g/L, promoted the growth of the fibroblast 
      up to 113%.
CI  - (c) 2020 American Chemical Society.
FAU - Rodriguez-Lopez, Lorena
AU  - Rodriguez-Lopez L
AD  - EQ10 Group, CINTECX, Department Chemical Engineering, Universidade de 
      Vigo-University of Vigo, Campus As Lagoas-Marcosende, 36310 Vigo, Spain.
FAU - Lopez-Prieto, Alejandro
AU  - Lopez-Prieto A
AD  - EQ10 Group, CINTECX, Department Chemical Engineering, Universidade de 
      Vigo-University of Vigo, Campus As Lagoas-Marcosende, 36310 Vigo, Spain.
FAU - Lopez-Alvarez, Miriam
AU  - Lopez-Alvarez M
AD  - New Materials Group, CINTECX, IISGS, Department Applied Physics, University of 
      Vigo, Campus Lagoas-Marcosende, Vigo 36310, Spain.
FAU - Perez-Davila, Sara
AU  - Perez-Davila S
AD  - New Materials Group, CINTECX, IISGS, Department Applied Physics, University of 
      Vigo, Campus Lagoas-Marcosende, Vigo 36310, Spain.
FAU - Serra, Julia
AU  - Serra J
AD  - New Materials Group, CINTECX, IISGS, Department Applied Physics, University of 
      Vigo, Campus Lagoas-Marcosende, Vigo 36310, Spain.
FAU - Gonzalez, Pio
AU  - Gonzalez P
AD  - New Materials Group, CINTECX, IISGS, Department Applied Physics, University of 
      Vigo, Campus Lagoas-Marcosende, Vigo 36310, Spain.
FAU - Cruz, Jose Manuel
AU  - Cruz JM
AD  - EQ10 Group, CINTECX, Department Chemical Engineering, Universidade de 
      Vigo-University of Vigo, Campus As Lagoas-Marcosende, 36310 Vigo, Spain.
FAU - Moldes, Ana B
AU  - Moldes AB
AD  - EQ10 Group, CINTECX, Department Chemical Engineering, Universidade de 
      Vigo-University of Vigo, Campus As Lagoas-Marcosende, 36310 Vigo, Spain.
LA  - eng
PT  - Journal Article
DEP - 20201124
PL  - United States
TA  - ACS Omega
JT  - ACS omega
JID - 101691658
PMC - PMC7726928
COIS- The authors declare no competing financial interest.
EDAT- 2020/12/17 06:00
MHDA- 2020/12/17 06:01
PMCR- 2020/11/24
CRDT- 2020/12/16 05:38
PHST- 2020/10/09 00:00 [received]
PHST- 2020/11/12 00:00 [accepted]
PHST- 2020/12/16 05:38 [entrez]
PHST- 2020/12/17 06:00 [pubmed]
PHST- 2020/12/17 06:01 [medline]
PHST- 2020/11/24 00:00 [pmc-release]
AID - 10.1021/acsomega.0c04933 [doi]
PST - epublish
SO  - ACS Omega. 2020 Nov 24;5(48):31381-31390. doi: 10.1021/acsomega.0c04933. 
      eCollection 2020 Dec 8.