PMID- 33325271
OWN - NLM
STAT- MEDLINE
DCOM- 20220224
LR  - 20220224
IS  - 1532-7914 (Electronic)
IS  - 0163-5581 (Linking)
VI  - 73
IP  - 11-12
DP  - 2021
TI  - Association of Helicobacter bilis Infection with the Development of Colorectal 
      Cancer.
PG  - 2785-2795
LID - 10.1080/01635581.2020.1862253 [doi]
AB  - The role of Helicobacter_bilis (H.bilis) in the development of inflammatory bowel 
      disease (IBD) and colitis-associated carcinogenesis (CAC) has seldom been 
      investigated. We examined the abundance of H.bilis in 58 colorectal cancers 
      (CRCs), 20 IBDs, 40 cases of normal colorectal mucosa (NCs), and 20 adenomas 
      (ADs) by 16S rRNA fluorescence in situ hybridization (FISH). Number of 
      CD4(+)CD45RB(+)T cell and expression of IFN-gamma and TNF-alpha in these tissues was 
      determined by immunofluorescence. The abundance of H.bilis was significantly 
      higher in CRCs than that in IBDs (P = 0.006), ADs (P < 0.001) and NCs 
      (P < 0.0001). The abundance of H.bilis in IBDs was significantly higher than that 
      in ADs (P = 0.013). Moreover, the average number of CD4(+)CD45RB(+)T cell was 
      significantly higher in CRCs than that in IBDs (P = 0.017) and NCs (P = 0.009). 
      In addition, there was a positive correlation between the H.bilis abundance and 
      density of CD4(+)CD45RB(+)T cells in 30 colorectal tissues (P < 0.0001). The 
      frequency of co-staining for CD4(+)CD45RB(+)T cells and IFN-gamma was significantly 
      higher in H.bilis positive group than that in H.bilis negative group (P = 0.002). 
      H.bilis may play a role in the initiation of IBD and CAC, possibly through 
      promoting the transformation of T cells into CD4(+)CD45RB(+)T cells and 
      increasing the expression of proinflammatory cytokines IFN-gamma.
FAU - Peng, Wei
AU  - Peng W
AD  - Department of Gastroenterology, the Affiliated Hospital of Southwest Medical 
      University, Sichuan, China.
FAU - Li, Huan
AU  - Li H
AD  - Department of Gastroenterology, the Affiliated Hospital of Southwest Medical 
      University, Sichuan, China.
FAU - Xu, Yun
AU  - Xu Y
AD  - Department of Gastroenterology, the People's Hospital of Guangan City, Sichuan, 
      China.
FAU - Yan, Li
AU  - Yan L
AD  - Digestive Endoscopy Center, the Affiliated Hospital of North Sichuan Medical 
      College, Sichuan, China.
FAU - Tang, Zhenzhen
AU  - Tang Z
AD  - Digestive Endoscopy Center, the Affiliated Hospital of North Sichuan Medical 
      College, Sichuan, China.
FAU - Hossein Mohseni, Amir
AU  - Hossein Mohseni A
AD  - Digestive Endoscopy Center, the Affiliated Hospital of North Sichuan Medical 
      College, Sichuan, China.
FAU - Taghinezhad-S, Sedigheh
AU  - Taghinezhad-S S
AD  - Digestive Endoscopy Center, the Affiliated Hospital of North Sichuan Medical 
      College, Sichuan, China.
FAU - Tang, Xiaowei
AU  - Tang X
AD  - Department of Gastroenterology, the Affiliated Hospital of Southwest Medical 
      University, Sichuan, China.
FAU - Fu, Xiangsheng
AU  - Fu X
AD  - Department of Gastroenterology, the Affiliated Hospital of Southwest Medical 
      University, Sichuan, China.
AD  - Digestive Endoscopy Center, the Affiliated Hospital of North Sichuan Medical 
      College, Sichuan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201216
PL  - United States
TA  - Nutr Cancer
JT  - Nutrition and cancer
JID - 7905040
RN  - 0 (RNA, Ribosomal, 16S)
RN  - Helicobacter bilis
SB  - IM
MH  - *Colorectal Neoplasms/complications
MH  - *Helicobacter
MH  - *Helicobacter Infections/complications
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - RNA, Ribosomal, 16S
EDAT- 2020/12/17 06:00
MHDA- 2022/02/25 06:00
CRDT- 2020/12/16 08:39
PHST- 2020/12/17 06:00 [pubmed]
PHST- 2022/02/25 06:00 [medline]
PHST- 2020/12/16 08:39 [entrez]
AID - 10.1080/01635581.2020.1862253 [doi]
PST - ppublish
SO  - Nutr Cancer. 2021;73(11-12):2785-2795. doi: 10.1080/01635581.2020.1862253. Epub 
      2020 Dec 16.