PMID- 33329564
OWN - NLM
STAT- MEDLINE
DCOM- 20210614
LR  - 20210614
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 11
DP  - 2020
TI  - Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell 
      Maturation and Function.
PG  - 586613
LID - 10.3389/fimmu.2020.586613 [doi]
LID - 586613
AB  - Dendritic cells (DCs) are specialized antigen-presenting cells that play a key 
      role in immune homeostasis and the adaptive immune response. DC-induced immune 
      tolerance or activation is strictly dependent on the distinct maturation stages 
      and migration ability of DCs. Ubiquitination is a reversible protein 
      post-translational modification process that has emerged as a crucial mechanism 
      that regulates DC maturation and function. Recent studies have shown that 
      ubiquitin enzymes, including E3 ubiquitin ligases and deubiquitinases (DUBs), are 
      pivotal regulators of DC-mediated immune function and serve as potential targets 
      for DC-based immunotherapy of immune-related disorders (e.g., autoimmune disease, 
      infections, and tumors). In this review, we summarize the recent progress 
      regarding the molecular mechanisms and function of ubiquitination in DC-mediated 
      immune homeostasis and immune response.
CI  - Copyright (c) 2020 Zhu, Zhu, Xia, Xiong, Yin and Rui.
FAU - Zhu, Bo
AU  - Zhu B
AD  - Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, 
      Zhenjiang, China.
FAU - Zhu, Lihua
AU  - Zhu L
AD  - Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, 
      Zhenjiang, China.
FAU - Xia, Lin
AU  - Xia L
AD  - Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, 
      Zhenjiang, China.
AD  - International Genome Center, Jiangsu University, Zhenjiang, China.
FAU - Xiong, Yuyun
AU  - Xiong Y
AD  - Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, 
      Zhenjiang, China.
FAU - Yin, Qing
AU  - Yin Q
AD  - Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, 
      Zhenjiang, China.
FAU - Rui, Ke
AU  - Rui K
AD  - Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, 
      Zhenjiang, China.
AD  - Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School 
      of Medicine, Jiangsu University, Zhenjiang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201116
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - Animals
MH  - Cell Differentiation/immunology
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Humans
MH  - Protein Processing, Post-Translational/immunology
MH  - Ubiquitination/*physiology
PMC - PMC7717991
OTO - NOTNLM
OT  - DC maturation
OT  - dendritic cells
OT  - immune responses
OT  - post-translational modification
OT  - ubiquitination
EDAT- 2020/12/18 06:00
MHDA- 2021/06/16 06:00
PMCR- 2020/01/01
CRDT- 2020/12/17 05:50
PHST- 2020/07/23 00:00 [received]
PHST- 2020/10/19 00:00 [accepted]
PHST- 2020/12/17 05:50 [entrez]
PHST- 2020/12/18 06:00 [pubmed]
PHST- 2021/06/16 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2020.586613 [doi]
PST - epublish
SO  - Front Immunol. 2020 Nov 16;11:586613. doi: 10.3389/fimmu.2020.586613. eCollection 
      2020.