PMID- 33330652
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220107
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 7
DP  - 2020
TI  - Ideal Cardiovascular Health Metrics and Incidence of Ischemic Stroke Among 
      Hypertensive Patients: A Prospective Cohort Study.
PG  - 590809
LID - 10.3389/fcvm.2020.590809 [doi]
LID - 590809
AB  - Background: This study aimed to assess the relationship between ideal 
      cardiovascular health (CVH) metrics and incident ischemic stroke (IS) in 
      hypertensive patients, especially those with hyperhomocysteinemia (HHcy). 
      Methods: A prospective cohort study enrolled 5,488 hypertensive patients in 
      Nanshan District of Shenzhen City in southern China from September 2011 to 
      December 2017. CVH metrics were defined according to the American Heart 
      Association. Cox proportional hazards models were used to examine the 
      associations between the number of ideal CVH metrics and the incidence of IS by 
      calculating multivariable-adjusted hazard ratios (HRs) and 95% CI. Results: 
      During an average follow-up of 5.7 years, 340 IS patients were identified. 
      Compared with those having 0 ideal CVH metrics, the HRs (95% CIs) for IS among 
      those with 1, 2, 3, 4, and 5-6 ideal CVH metrics were 0.62 (0.31-1.25), 0.37 
      (0.19-0.74), 0.37 (0.18-0.74), 0.34 (0.16-0.71), and 0.28 (0.12-0.63), 
      respectively (P < 0.001). An ideal healthy diet score and ideal fasting blood 
      glucose level were independently associated with IS among participants, with HRs 
      (95% CIs) of 0.53 (0.33-0.86) and 0.32 (0.17-0.66), respectively. Additionally, 
      compared with those with normal total homocysteine (tHcy) levels (<15 mumol/L), 
      the HR (95% CI) for IS among participants with HHcy and who had 5-6 ideal CVH 
      metrics was 0.50 (0.27-0.92). Conclusion: An increased number of ideal CVH 
      metrics was inversely associated with the incidence of IS in hypertensive 
      patients. The participants with HHcy who had 5-6 ideal CVH metrics exhibited a 
      lower IS risk than those with normal tHcy levels.
CI  - Copyright (c) 2020 Ying, Lin, Kong, Li, Xu, Liang, Wang and Han.
FAU - Ying, Yuchen
AU  - Ying Y
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, China.
FAU - Lin, Shaoyi
AU  - Lin S
AD  - Cardiology Department, Ningbo First Hospital, Ningbo, China.
FAU - Kong, Fanqian
AU  - Kong F
AD  - Department of Medical Record and Statistics, Ningbo Medical Center Lihuili 
      Hospital, Ningbo, China.
FAU - Li, Yuying
AU  - Li Y
AD  - Shenzhen Polytechnic, Shenzhen, China.
FAU - Xu, Shujun
AU  - Xu S
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, China.
FAU - Liang, Xiaofeng
AU  - Liang X
AD  - Chinese Preventive Medicine Association, Beijing, China.
FAU - Wang, Changyi
AU  - Wang C
AD  - Department of Chronic Disease Prevention and Control, Shenzhen Nanshan Center for 
      Chronic Disease Control, Shenzhen, China.
FAU - Han, Liyuan
AU  - Han L
AD  - Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
AD  - Department of Global Health, Ningbo Institute of Life and Health Industry, 
      University of Chinese Academy of Sciences, Ningbo, China.
LA  - eng
PT  - Journal Article
DEP - 20201123
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
EIN - Front Cardiovasc Med. 2021 Dec 21;8:829078. PMID: 34993243
PMC - PMC7719670
OTO - NOTNLM
OT  - hyperhomocysteinemia
OT  - hypertensive patients
OT  - ideal cardiovascular health metrics
OT  - ischemic stroke
OT  - prospective study
EDAT- 2020/12/18 06:00
MHDA- 2020/12/18 06:01
PMCR- 2020/01/01
CRDT- 2020/12/17 05:54
PHST- 2020/08/03 00:00 [received]
PHST- 2020/09/29 00:00 [accepted]
PHST- 2020/12/17 05:54 [entrez]
PHST- 2020/12/18 06:00 [pubmed]
PHST- 2020/12/18 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2020.590809 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2020 Nov 23;7:590809. doi: 10.3389/fcvm.2020.590809. 
      eCollection 2020.