PMID- 33330982
OWN - NLM
STAT- MEDLINE
DCOM- 20211021
LR  - 20220531
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 92
IP  - 9
DP  - 2021 Sep
TI  - Salivary and serum concentrations of monocyte chemoattractant protein-1, 
      macrophage inhibitory factor, and fractalkine in relation to rheumatoid arthritis 
      and periodontitis.
PG  - 1295-1305
LID - 10.1002/JPER.20-0632 [doi]
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1), macrophage migration 
      inhibitory factor (MIF), and fractalkine are chemokines that are expressed by a 
      variety of cell types to regulate macrophage inflammatory response. The aim of 
      the study was to examine the effects of periodontitis and rheumatoid arthritis 
      (RA) on their serum and salivary concentrations. METHODS: Adults with either 
      periodontitis (P, n = 21), or with rheumatoid arthritis (RA, n = 23), or with 
      both diseases (RA+P, n = 23) were included in the study. Systemically and 
      periodontally healthy individuals (n = 22) served as controls. Saliva and serum 
      samples were collected from all participants before the medical and periodontal 
      examinations. Salivary and serum MCP-1, MIF, and fractalkine concentrations were 
      measured by the Luminex technique. Total salivary protein levels were determined 
      by the Bradford assay. RESULTS: Salivary MCP-1, MIF, and fractalkine 
      concentrations were elevated in both RA groups (RA+P and RA) in comparison with 
      systemically healthy controls. As related to total salivary protein levels, 
      higher MCP-1 (P = 0.003) and fractalkine (P = 0.045) concentrations were found in 
      controls compared with the P group. In serum, MCP-1 concentrations in the RA+P 
      group were higher (P = 0.003) than those of group P. Elevated serum fractalkine 
      concentrations were observed in both periodontitis groups (RA+P, P = 0.014; and 
      P, P = 0.013) compared with controls. CONCLUSIONS: In RA, MCP-1, MIF, and 
      fractalkine concentrations are elevated in saliva. These chemokines may disrupt 
      oral macrophage responses and potentially take part in the interaction between 
      periodontitis and RA.
CI  - (c) 2020 American Academy of Periodontology.
FAU - Yilmaz, Dogukan
AU  - Yilmaz D
AD  - Department of Periodontology, Faculty of Dentistry, Sakarya University, Sakarya, 
      Turkey.
FAU - Gonullu, Emel
AU  - Gonullu E
AD  - Department of Rheumatology, Faculty of Medicine, Sakarya University, Sakarya, 
      Turkey.
FAU - Gursoy, Mervi
AU  - Gursoy M
AD  - Department of Periodontology, Institute of Dentistry, University of Turku, Turku, 
      Finland.
FAU - Kononen, Eija
AU  - Kononen E
AD  - Department of Periodontology, Institute of Dentistry, University of Turku, Turku, 
      Finland.
AD  - Oral Health Care, Welfare Division, City of Turku, Turku, Finland.
FAU - Gursoy, Ulvi Kahraman
AU  - Gursoy UK
AD  - Department of Periodontology, Institute of Dentistry, University of Turku, Turku, 
      Finland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210103
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (CCL2 protein, human)
RN  - 0 (CX3CL1 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CX3CL1)
RN  - 0 (Macrophage Migration-Inhibitory Factors)
RN  - EC 5.3.- (Intramolecular Oxidoreductases)
RN  - EC 5.3.2.1 (MIF protein, human)
SB  - IM
MH  - *Arthritis, Rheumatoid
MH  - Chemokine CCL2
MH  - Chemokine CX3CL1
MH  - Humans
MH  - Intramolecular Oxidoreductases
MH  - *Macrophage Migration-Inhibitory Factors
MH  - *Periodontitis
OTO - NOTNLM
OT  - inflammation
OT  - innate immunity
OT  - periodontitis
OT  - saliva
EDAT- 2020/12/18 06:00
MHDA- 2022/06/01 06:00
CRDT- 2020/12/17 05:56
PHST- 2020/12/01 00:00 [revised]
PHST- 2020/08/24 00:00 [received]
PHST- 2020/12/13 00:00 [accepted]
PHST- 2020/12/18 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2020/12/17 05:56 [entrez]
AID - 10.1002/JPER.20-0632 [doi]
PST - ppublish
SO  - J Periodontol. 2021 Sep;92(9):1295-1305. doi: 10.1002/JPER.20-0632. Epub 2021 Jan 
      3.