PMID- 33332228
OWN - NLM
STAT- MEDLINE
DCOM- 20210428
LR  - 20231111
IS  - 1477-0377 (Electronic)
IS  - 1358-863X (Print)
IS  - 1358-863X (Linking)
VI  - 26
IP  - 2
DP  - 2021 Apr
TI  - A cross-sectional study evaluating hospitalization rates for chronic 
      limb-threatening ischemia during the COVID-19 outbreak in Campania, Italy.
PG  - 174-179
LID - 10.1177/1358863X20977678 [doi]
AB  - The expansion of coronavirus disease 2019 (COVID-19) prompted measures of disease 
      containment by the Italian government with a national lockdown on March 9, 2020. 
      The purpose of this study is to evaluate the rate of hospitalization and mode of 
      in-hospital treatment of patients with chronic limb-threatening ischemia (CLTI) 
      before and during lockdown in the Campania region of Italy. The study population 
      includes all patients with CLTI hospitalized in Campania over a 10-week period: 5 
      weeks before and 5 weeks during lockdown (n = 453). Patients were treated 
      medically and/or underwent urgent revascularization and/or major amputation of 
      the lower extremities. Mean age was 69.2 +/- 10.6 years and 27.6% of the patients 
      were women. During hospitalization, 21.9% of patients were treated medically, 
      78.1% underwent revascularization, and 17.4% required amputations. In the weeks 
      during the lockdown, a reduced rate of hospitalization for CLTI was observed 
      compared with the weeks before lockdown (25 vs 74/100,000 inhabitants/year; 
      incidence rate ratio: 0.34, 95% CI 0.32-0.37). This effect persisted to the end 
      of the study period. An increased amputation rate in the weeks during lockdown 
      was observed (29.3% vs 13.4%; p < 0.001). This study reports a reduced rate of 
      CLTI-related hospitalization and an increased in-hospital amputation rate during 
      lockdown in Campania. Ensuring appropriate treatment for patients with CLTI 
      should be prioritized, even during disease containment measures due to the 
      COVID-19 pandemic or other similar conditions.
FAU - Stabile, Eugenio
AU  - Stabile E
AUID- ORCID: 0000-0001-9763-6010
AD  - Department of Advanced Biomedical Sciences, Division of Cardiology, University of 
      Naples Federico II, Naples, Italy.
FAU - Piccolo, Raffaele
AU  - Piccolo R
AD  - Department of Advanced Biomedical Sciences, Division of Cardiology, University of 
      Naples Federico II, Naples, Italy.
FAU - Franzese, Michele
AU  - Franzese M
AD  - Department of Advanced Biomedical Sciences, Division of Cardiology, University of 
      Naples Federico II, Naples, Italy.
FAU - Accarino, Giancarlo
AU  - Accarino G
AD  - Department of Vascular and Endovascular Surgery, AOU San Giovanni di Dio e Ruggi 
      d'Aragona, Salerno, Italy.
FAU - Bracale, Umberto Marcello
AU  - Bracale UM
AD  - Department of Public Health, Division of Vascular Surgery, University of Naples 
      Federico II, Naples, Italy.
FAU - Cappello, Enrico
AU  - Cappello E
AD  - Division of Vascular and Endovascular Surgery, Mediterranea Centro Cuore, Naples, 
      Italy.
FAU - Cioffi, Giovanni
AU  - Cioffi G
AD  - Division of Vascular Surgery, Ospedale Pellegrini, Naples, Italy.
FAU - Cioppa, Angelo
AU  - Cioppa A
AD  - Division of Invasive Cardiology, Clinica Montevergine, Mercogliano, Italy.
FAU - Crinisio, Adolfo
AU  - Crinisio A
AD  - Division of Vascular and Endovascular Surgery, Clinica Salus, Battipaglia, Italy.
FAU - Flora, Loris
AU  - Flora L
AD  - Division of Vascular Surgery, AORN San Giuseppe Moscati, Avellino, Italy.
FAU - Landino, Pietro
AU  - Landino P
AD  - Department of Cardiology and Cardiac Surgery, Casa di Cura S. Michele, Maddaloni, 
      Italy.
FAU - Martelli, Eugenio
AU  - Martelli E
AUID- ORCID: 0000-0001-5764-0082
AD  - Division of Vascular and Endovascular Surgery, AORN Sant'Anna e San Sebastiano, 
      Caserta, Italy.
FAU - Mancusi, Rosario
AU  - Mancusi R
AD  - Division of Vascular and Endovascular Surgery, Villa dei Fiori Hospital, Acerra, 
      Italy.
FAU - Niola, Raffaella
AU  - Niola R
AD  - Division of Vascular and Interventional Radiology, AORN Cardarelli, Naples, 
      Italy.
FAU - Petrosino, Fernando
AU  - Petrosino F
AD  - Division of Vascular Surgery, Presidio Ospedaliero 'San Luca', Vallo della 
      Lucania, Italy.
FAU - Razzano, Davide
AU  - Razzano D
AD  - Division of Vascular Surgery, AO San Pio, Benevento, Italy.
FAU - Ruotolo, Carlo
AU  - Ruotolo C
AD  - Division of Vascular Surgery, AORN Cardarelli, Naples, Italy.
FAU - Salemme, Luigi
AU  - Salemme L
AD  - Division of Invasive Cardiology, Clinica Montevergine, Mercogliano, Italy.
FAU - Sangiuolo, Paolo
AU  - Sangiuolo P
AD  - Division of Vascular Surgery, AORN Ospedali dei Colli, Monaldi Hospital, Naples, 
      Italy.
FAU - Santini, Gianpaolo
AU  - Santini G
AD  - Department of Radiology, Ospedale del Mare, Naples, Italy.
FAU - Soreca, Emilio
AU  - Soreca E
AD  - Department of Radiology, AO San Pio, Benevento, Italy.
FAU - Vigliotti, Gennaro
AU  - Vigliotti G
AD  - Division of Vascular Surgery, Ospedale del Mare, Naples, Italy.
FAU - Villari, Bruno
AU  - Villari B
AD  - Division of Cardiology, Ospedale Sacro Cuore di Gesu, Benevento, Italy.
FAU - Amabile, Giampaolo
AU  - Amabile G
AD  - Division of Vascular and Interventional Radiology, AORN Cardarelli, Naples, 
      Italy.
FAU - Ammollo, Raffaele Pio
AU  - Ammollo RP
AD  - Department of Public Health, Division of Vascular Surgery, University of Naples 
      Federico II, Naples, Italy.
FAU - Barbarisi, Danilo
AU  - Barbarisi D
AD  - Division of Vascular Surgery, AORN San Giuseppe Moscati, Avellino, Italy.
FAU - Corbisiero, Alfonsina M
AU  - Corbisiero AM
AD  - Department of Cardiology and Cardiac Surgery, Casa di Cura S. Michele, Maddaloni, 
      Italy.
FAU - D'angelo, Antonio
AU  - D'angelo A
AD  - Department of Vascular and Endovascular Surgery, AOU San Giovanni di Dio e Ruggi 
      d'Aragona, Salerno, Italy.
FAU - Cangiano, Gianluca
AU  - Cangiano G
AD  - Division of Vascular and Interventional Radiology, AORN Cardarelli, Naples, 
      Italy.
FAU - De Gregorio, Claudia
AU  - De Gregorio C
AD  - Division of Vascular and Endovascular Surgery, Villa dei Fiori Hospital, Acerra, 
      Italy.
FAU - De Laurentis, Mario
AU  - De Laurentis M
AD  - Division of Vascular Surgery, AORN Ospedali dei Colli, Monaldi Hospital, Naples, 
      Italy.
FAU - Laurenzano, Eugenio
AU  - Laurenzano E
AD  - Division of Cardiology, Ospedale Sacro Cuore di Gesu, Benevento, Italy.
FAU - Ficarelli, Ilaria
AU  - Ficarelli I
AD  - Division of Vascular Surgery, AORN Cardarelli, Naples, Italy.
FAU - Luongo, Alessandro
AU  - Luongo A
AD  - Division of Vascular Surgery, Presidio Ospedaliero 'San Luca', Vallo della 
      Lucania, Italy.
FAU - Molino, Claudio
AU  - Molino C
AD  - Division of Vascular and Endovascular Surgery, Clinica Salus, Battipaglia, Italy.
FAU - Sarti, Giuseppe
AU  - Sarti G
AD  - Department of Radiology, Ospedale del Mare, Naples, Italy.
FAU - Viola, Daniela
AU  - Viola D
AD  - Division of Vascular Surgery, Ospedale del Mare, Naples, Italy.
FAU - Esposito, Giovanni
AU  - Esposito G
AD  - Department of Advanced Biomedical Sciences, Division of Cardiology, University of 
      Naples Federico II, Naples, Italy.
LA  - eng
PT  - Journal Article
DEP - 20201217
PL  - England
TA  - Vasc Med
JT  - Vascular medicine (London, England)
JID - 9610930
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - COVID-19/*epidemiology/*virology
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - Extremities/*physiopathology
MH  - Female
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Ischemia/*epidemiology/physiopathology/virology
MH  - Italy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Peripheral Arterial Disease/complications/virology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - SARS-CoV-2/*pathogenicity
PMC - PMC8033437
OTO - NOTNLM
OT  - COVID-19
OT  - chronic limb-threatening ischemia (CLTI)
OT  - peripheral artery disease (PAD)
COIS- Declaration of conflicting interests: The authors declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2020/12/18 06:00
MHDA- 2021/04/29 06:00
PMCR- 2021/04/09
CRDT- 2020/12/17 17:16
PHST- 2020/12/18 06:00 [pubmed]
PHST- 2021/04/29 06:00 [medline]
PHST- 2020/12/17 17:16 [entrez]
PHST- 2021/04/09 00:00 [pmc-release]
AID - 10.1177_1358863X20977678 [pii]
AID - 10.1177/1358863X20977678 [doi]
PST - ppublish
SO  - Vasc Med. 2021 Apr;26(2):174-179. doi: 10.1177/1358863X20977678. Epub 2020 Dec 
      17.