PMID- 33332810
OWN - NLM
STAT- MEDLINE
DCOM- 20211210
LR  - 20230817
IS  - 1539-2864 (Electronic)
IS  - 0275-004X (Print)
IS  - 0275-004X (Linking)
VI  - 41
IP  - 7
DP  - 2021 Jul 1
TI  - PENTOSAN POLYSULFATE AND VISION: Findings from an International Survey of Exposed 
      Individuals.
PG  - 1562-1569
LID - 10.1097/IAE.0000000000003078 [doi]
AB  - PURPOSE: To investigate patient-reported visual function among individuals taking 
      pentosan polysulfate (PPS) for interstitial cystitis. METHODS: A 27-item online 
      survey was distributed to an international mailing list of individuals with 
      interstitial cystitis in November 2018. Demographic characteristics, PPS exposure 
      history, subjective visual function, and previous macular diagnoses were queried. 
      The impact of PPS use, grouped by tertile of cumulative exposure, on visual 
      function and macular diagnoses was assessed with multivariate logistic 
      regression. RESULTS: The survey was completed by 912 respondents. Eight hundred 
      and sixty-one (96.4%) were women, and the median age was 55 [interquartile range 
      (IQR), 45-64 years]. Among PPS users, the median exposure was 547.5 g (IQR, 
      219-1,314 g). Respondents in the highest PPS exposure tertile were more likely to 
      report difficulty with reading small print [adjusted odds ratio 2.29, 95% 
      confidence interval (CI) 1.15-4.57] and to have a diagnosis of macular 
      degeneration and/or pigmentary maculopathy (adjusted odds ratio 2.41, 95% CI 
      1.44-4.03) than unexposed respondents. CONCLUSION: In this large sample of 
      individuals with interstitial cystitis, those in the highest PPS exposure 
      category were more likely to have difficulties reading small print and to report 
      a previous diagnosis of macular disease. Further study of objective measures of 
      visual function in PPS users is warranted.
FAU - Uner, Ogul E
AU  - Uner OE
AD  - Emory University School of Medicine, Atlanta, Georgia.
FAU - Shah, Megha K
AU  - Shah MK
AD  - Department of Family and Preventive Medicine, Emory University School of 
      Medicine, Atlanta, Georgia ; and.
FAU - Jain, Nieraj
AU  - Jain N
AD  - Department of Ophthalmology, Emory University School of Medicine, Atlanta, 
      Georgia.
LA  - eng
GR  - K23 MD015088/MD/NIMHD NIH HHS/United States
GR  - KL2 TR002381/TR/NCATS NIH HHS/United States
GR  - UL1 TR002378/TR/NCATS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
RN  - 0 (Anticoagulants)
RN  - 37300-21-3 (Pentosan Sulfuric Polyester)
SB  - IM
MH  - Anticoagulants/adverse effects/therapeutic use
MH  - Cystitis, Interstitial/*drug therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pentosan Sulfuric Polyester/*adverse effects/therapeutic use
MH  - Retinal Diseases/*chemically induced/diagnosis
MH  - Retinal Pigment Epithelium/diagnostic imaging/*drug effects
MH  - Retrospective Studies
MH  - *Surveys and Questionnaires
PMC - PMC8200367
MID - NIHMS1653387
COIS- No conflicting relationship exists for any author.
EDAT- 2020/12/18 06:00
MHDA- 2021/12/15 06:00
PMCR- 2022/07/01
CRDT- 2020/12/17 17:55
PHST- 2020/12/18 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/12/17 17:55 [entrez]
PHST- 2022/07/01 00:00 [pmc-release]
AID - 00006982-202107000-00027 [pii]
AID - 10.1097/IAE.0000000000003078 [doi]
PST - ppublish
SO  - Retina. 2021 Jul 1;41(7):1562-1569. doi: 10.1097/IAE.0000000000003078.