PMID- 33334608
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 0242-6498 (Print)
IS  - 0242-6498 (Linking)
VI  - 41
IP  - 2
DP  - 2021 Apr
TI  - [Gastric bacterial overgrowth: An unusual histological observation, not to be 
      overlooked].
PG  - 196-200
LID - S0242-6498(20)30270-4 [pii]
LID - 10.1016/j.annpat.2020.11.005 [doi]
AB  - Gastric bacterial overgrowth is a rare situation, which may be associated with 
      short- and long-term complications. It must be known from pathologists, since it 
      might be detected incidentally at histological examination of gastric biopsies. 
      We report here the case of a 74-year old woman, obese, without significant 
      medical history, apart from a gastro-esophageal reflux treated by the long-term 
      administration of proton pump inhibitors (PPI). In this patient, gastric 
      bacterial overgrowth was detected at histological examination of gastric biopsies 
      performed after colectomy for left colon adenocarcinoma. Large clusters of small, 
      round, "coccoid" bacteria were present in the gastric mucus. Their 
      characteristics were suggestive of enterobacteria. Bacterial proliferation was 
      associated with severe and diffuse lesions of active gastritis. The course was 
      rapidly unfavorable, and the patient rapidly deceased with multiple infections 
      and multi-organ failure. In our observation, the pathogenesis of gastric 
      bacterial overgrowth was probably multifactorial. It might have been facilitated 
      by long-term PPI treatment and obesity, which are known risk factors, and 
      promoted, in the post-operative setting, by multiple infections and immune 
      failure. Our observation underlines that gastric bacterial overgrowth might be 
      associated with severe gastritis, which might justify antibiotherapy. Other 
      consequences of prolonged gastric dysbiosis cannot be excluded, such as the 
      promotion of neoplastic lesions.
CI  - Copyright (c) 2020 Elsevier Masson SAS. All rights reserved.
FAU - Langlois, Valentine
AU  - Langlois V
AD  - Service de Pathologie Morphologique, Departement de Biologie et Pathologie 
      Medicales, Gustave-Roussy Cancer Campus, 94805 Villejuif, France.
FAU - Joyon, Natacha
AU  - Joyon N
AD  - Service de Pathologie Morphologique, Departement de Biologie et Pathologie 
      Medicales, Gustave-Roussy Cancer Campus, 94805 Villejuif, France. Electronic 
      address: natacha.joyon@gustaveroussy.fr.
FAU - Farah, Rita Bou
AU  - Farah RB
AD  - Service d'Oncologie Digestive, Departement de Medecine, Gustave-Roussy Cancer 
      Campus, 94805 Villejuif, France.
FAU - Chachaty, Elisabeth
AU  - Chachaty E
AD  - Service de Microbiologie, Departement de Biologie et Pathologie Medicales, 
      Gustave-Roussy Cancer Campus, 94805 Villejuif, France.
FAU - Scoazec, Jean-Yves
AU  - Scoazec JY
AD  - Service de Pathologie Morphologique, Departement de Biologie et Pathologie 
      Medicales, Gustave-Roussy Cancer Campus, 94805 Villejuif, France; Universite 
      Paris Sud, Faculte de Medecine de Bicetre, 94270 Le Kremlin-Bicetre, France.
LA  - fre
PT  - Case Reports
PT  - Journal Article
TT  - Pullulation bacterienne gastrique : une observation histologique inhabituelle, a 
      ne pas meconnaitre.
DEP - 20201214
PL  - France
TA  - Ann Pathol
JT  - Annales de pathologie
JID - 8106337
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Female
MH  - *Gastritis
MH  - Humans
MH  - *Proton Pump Inhibitors/adverse effects
MH  - Risk Factors
OTO - NOTNLM
OT  - Enterobacteria
OT  - Enterobacteries
OT  - Gastric bacterial overgrowth
OT  - Gastrite
OT  - Gastritis
OT  - Microbiota
OT  - Microbiote
OT  - Pullulation bacterienne
EDAT- 2020/12/19 06:00
MHDA- 2021/10/16 06:00
CRDT- 2020/12/18 05:32
PHST- 2020/03/02 00:00 [received]
PHST- 2020/10/26 00:00 [revised]
PHST- 2020/11/16 00:00 [accepted]
PHST- 2020/12/19 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2020/12/18 05:32 [entrez]
AID - S0242-6498(20)30270-4 [pii]
AID - 10.1016/j.annpat.2020.11.005 [doi]
PST - ppublish
SO  - Ann Pathol. 2021 Apr;41(2):196-200. doi: 10.1016/j.annpat.2020.11.005. Epub 2020 
      Dec 14.